Results 101 to 110 of about 63,855 (231)

Clinical outcomes of empirical topical nifuratel or nitrofurantoin in Streptococcus pyogenes vulvovaginitis: A retrospective study

International Journal of Gynecology &Obstetrics, EarlyView.
Marek Stefan, Kristyna Krogh, Jaroslava Zikova, Marta Novackova, Marcela Krutova   +4 more
wiley   +1 more source

Beat‐to‐beat variability of ventricular repolarization reveals sex‐specific instability and proarrhythmic risk

The Journal of Physiology, EarlyView.
Abstract figure legend A mechanistic framework linking sex‐dependent dynamical instability to proarrhythmic risk. Sex‐specific human ventricular models show that upstream modulators, including biological sex, hormones, drugs and heart disease, promote steeper APD restitution in female than male and enhance dynamical instability.
Daisuke Sato, Lorenzo Santini, Raffaele Coppini, Eleonora Grandi   +3 more
wiley   +1 more source

Clinical guideline highlights for the hospitalist: Updates on the treatment of drug‐susceptible and drug‐resistant tuberculosis

Journal of Hospital Medicine, EarlyView.
Allison Stickles, Anna Poston‐Blahnik, Elizabeth Schlaudecker, Moises Huaman   +3 more
wiley   +1 more source

Dermatologic Toxicities Associated With Novel Pan‐RAS/RAF Inhibitors

Journal of Cutaneous Pathology, Volume 53, Issue 11, Page 1042-1050, November 2026.
ABSTRACT Background The mitogen‐activated protein kinase (MAPK) pathway plays a key role in cell‐cycle regulation and tumor progression in cancer. Dermatologic toxicities (DTs) to newer pan‐RAS (RMC‐6236) and pan‐RAF (LXH254/naporafenib) inhibitors are emerging.
Lin J. He, Shaymaa Hegazy, Phyu P. Aung, Priyadharsini Nagarajan, Fiorinda Muhaj, Adrienne N. Choksi, Ana M. Ciurea, Kelly C. Nelson, Doina Ivan, Carlos A. Torres‐ Cabala, Victor G. Prieto, Jonathan L. Curry   +11 more
wiley   +1 more source

Protective effects of adenosine triphosphate, thiamin, thiamin pyrophosphate, and their combination against linezolid-induced renal injury and lactic acidosis in rats

Renal Failure
Linezolid, an oxazolidinone antibiotic effective against Gram-positive pathogens, may cause nephrotoxicity and lactic acidosis during prolonged therapy. This experimental study investigated the protective effects of adenosine triphosphate (ATP), thiamin,
Ozlem Admis, Bulent Yavuzer, Renad Mammadov, Bahadir Suleyman, Durdu Altuner, Ali Sefa Mendil, Nurinisa Yucel, Halis Suleyman   +7 more
doaj   +1 more source

Linezolid Dependence in Staphylococcus epidermidis Bloodstream Isolates

Emerging Infectious Diseases, 2013
We document linezolid dependence among 5 highly linezolid-resistant (LRSE) Staphylococcus epidermidis bloodstream isolates that grew substantially faster at 32 µg/mL linezolid presence.
Spyros Pournaras, Eleni Ntokou, Olympia Zarkotou, Kyriaki Ranellou, Katerina Themeli-Digalaki, Constantinos Stathopoulos, Athanassios Tsakris   +6 more
doaj   +1 more source

Beyond the Monolayer: Leveraging 3D Culture Systems to Decode Mechanisms of Drug Resistance and Therapeutic Vulnerabilities in Colorectal Cancer

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT Two‐dimensional (2D) monolayer cultures remain the workhorse of colorectal cancer (CRC) research and high‐throughput screening (HTS), yet they poorly recapitulate tissue architecture, extracellular matrix (ECM) cues, metabolic gradients, and multicellular heterogeneity that govern drug response in vivo. Over the past decade, three‐dimensional (
Sarah J. Harmych, Bhuminder Singh
wiley   +1 more source

Hypertriglyceridemic Acute Pancreatitis With Concomitant Retrocecal Appendicitis: A Case Report

Clinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT Hypertriglyceridemia‐induced acute pancreatitis and acute appendicitis are distinct clinical conditions rarely reported to occur concurrently. We present a case of hypertriglyceridemia‐induced pancreatitis characterized by clinical deterioration despite a decline in serum triglyceride levels.
Mansoureh Shekarchizadeh Esfahani, Masood Shekarchizadeh, Seyed Amirhossein Dormiani Tabatabaei, Mehrnazsadat Dormiani Tabatabaei   +3 more
wiley   +1 more source

Post‐Dengue Deep Vein Thrombosis Complicated by Pulmonary Embolism: A Case Report

Clinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT Dengue fever is commonly associated with bleeding complications, particularly in patients with thrombocytopenia. However, thrombotic events, such as venous thromboembolism, are rare and under‐recognized manifestations, particularly during the recovery phase, posing diagnostic and therapeutic challenges.
Sarah Nisar, Hamza Mushtaq, Muhammad Haris Khan, Fatima Sajjad, Abdullah Afridi, Noor E Fatima, Kamil Ahmad Kamil   +6 more
wiley   +1 more source

Antimicrobial agents against vancomycin-resistant enterocci (Linezolid)

, 2002
Linezolid（LZD）は米国ファルマシア・アップジョン社で合成されたoxazolidinone 骨格を有する薬剤であり，30 年ぶりに新しい分類に属する抗菌薬として開発されている。LZD は50 S サブユニットのドメインV に特異的に結合することにより，50 S リボゾーム，30 S リボゾーム，m.RNA およびf.Met.t.RNA からなる開始複合体の形成を阻害する。その結果，既存の抗菌薬と異なり，蛋白合成の開始を抑制することにより抗菌力を発揮する。LZD は，メチシリン耐性黄色ブドウ球菌（
壼原, 克紀, 河野, 茂
core