Results 101 to 110 of about 60,035 (201)

Evaluating Prescriber Adherence to Guideline-Based Treatment Pathways of a Newly Initiated Antimicrobial Stewardship Program at a Rehabilitation Hospital [PDF]

, 2017
Background: Inappropriate use of antimicrobials in the healthcare setting is associated with consequences including antimicrobial resistance, Clostridium difficile infection (CDI), adverse drug reactions, and increased healthcare costs.
Bertram, Christie
core   +1 more source

LINEZOLID [PDF]

Medical Journal Armed Forces India, 2002
openaire   +3 more sources

High accumulation of linezolid and its major metabolite in the serum of patients with hepatic and renal dysfunction is significantly associated with thrombocytopenia and anemia

Microbiology Spectrum
This study aims to examine the serum levels of linezolid and its metabolites (PNU-142300 and PNU-142586) in patients with varying hepatic and renal function.
Junqiang Gou, Qian Li, Ning Fan, Chen Zhang, Haiwen Tang, Xiaofeng Wang, Dongfeng Yin   +6 more
doaj   +1 more source

Risk factors for linezolid - induced haematological toxicity in patients: a retrospective study

Journal of Infection in Developing Countries
Introduction: This single-center, observational cohort study aimed to investigate the risk factors associated with linezolid-induced hematological toxicity by analyzing the linezolid trough concentration (Cmin) obtained from patients undergoing ...
Kai Mo, Wen Cao, YaTing Lu, JuMan Li, RuHua Wei, MingWei Meng, YingE Liang, Hui Zhong, YanE Qin, XiaoBu Lan   +9 more
doaj   +1 more source

Pharmacokinetics, optimal dosing, and safety of linezolid in children with multidrug-resistant tuberculosis: Combined data from two prospective observational studies.

PLoS Medicine, 2019
BackgroundLinezolid is increasingly important for multidrug-resistant tuberculosis (MDR-TB) treatment. However, among children with MDR-TB, there are no linezolid pharmacokinetic data, and its adverse effects have not yet been prospectively described. We
Anthony J Garcia-Prats, H Simon Schaaf, Heather R Draper, Maria Garcia-Cremades, Jana Winckler, Lubbe Wiesner, Anneke C Hesseling, Rada M Savic   +7 more
doaj   +1 more source

Cfr Gene-based Detection of Linezolid-Resistant Staphylococcus Aureus in a Tertiary Care Hospital in Western Uttar Pradesh, India

Medical Journal of Dr. D.Y. Patil Vidyapeeth
Objective Linezolid is an important antimicrobial agent which is active against multidrug-resistant Gram-positive cocci. Methicillin-resistant Staphylococcus aureus (MRSA) cause life-threatening infection, with narrow therapeutic options including ...
Km. Sangita, Anita Pandey, Geeta Gupta, Ankita Gupta   +3 more
doaj   +1 more source

The protective role of vitamin C against linezolid-induced hepato-renal toxicity in a rat model

Frontiers in Pharmacology
This study investigated the protective effects of vitamin C against linezolid-induced hepatotoxicity and nephrotoxicity in rats using biochemical, histopathological, and immunohistochemical methods. Twenty-four rats were divided into four groups: control,
Shaimaa M. Azzam, Hend Mohamed Anwar, Ahmed H. Abd El-Slam, Marwa S. M. Diab, Halima Mohamed Ibrahim, Abdalrahman Mohammed Yousef, Fatma Mahmoud Sabry, Ibrahim A. Darwish, Kalidasan Kaliyamoorthy, Gad Elsayed Mohamed Salem, Heba M. A. Elsanhory   +10 more
doaj   +1 more source

Linezolid for multidrug-resistant tuberculosis. [PDF]

, 2013
Cox, H, Ford, N, Goemaere, E, Hughes, J
core   +2 more sources

Protective Effect of Exogenous Adenosine Triphosphate Against Ocular Toxicity of Linezolid in Rats

Life
Linezolid, a synthetic antimicrobial agent, may induce oxidative damage in ocular tissues, particularly in the optic nerve. Adenosine triphosphate (ATP) is involved in the production of antioxidants that scavenge and neutralize reactive oxygen species ...
Cenap Mahmut Esenulku, Ibrahim Cicek, Ahmet Mehmet Somuncu, Bulent Yavuzer, Esra Tuba Sezgin, Tugba Bal Tastan, Nurinisa Yücel, Ezgi Karatas, Halis Suleyman   +8 more
doaj   +1 more source

Population Pharmacokinetic Model‐Based Optimization of Linezolid Dosing in Hematooncological Patients With Suspected or Proven Gram‐Positive Sepsis

Clinical and Translational Science
The objective of this study was to develop a population pharmacokinetic model for linezolid in hematooncological patients with sepsis, and to propose dosing optimization based on pharmacokinetic covariates that would lead to improved achievement of the ...
Alžběta Zavřelová, Sara Merdita, Pavel Žák, Jakub Radocha, Benjamin Víšek, Miriam Lánská, Jana Maláková, Pavel Michálek, Ondřej Slanař, Martin Šíma   +9 more
doaj   +1 more source