Results 111 to 120 of about 63,855 (231)

Reappraisal of Linezolid Dosing in Renal Impairment To Improve Safety

Antimicrobial Agents and Chemotherapy, 2019
Linezolid is administered as a fixed dose to all patients despite evidence of increased exposure and myelosuppression in renal impairment. The objectives of these studies were to assess the risk of thrombocytopenia with standard-dose linezolid in renal ...
R. Crass, P. Cojutti, M. Pai, F. Pea
semanticscholar   +1 more source

How to Avoid Misdiagnosing Primary Spinal Epidural Abscess as Spinal Epidural Hematoma: A Case Report and Literature Review

Clinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT Spinal epidural abscess (SEA) is an easily misdiagnosed disease. We report a case of primary SEA (PSEA) that was misdiagnosed as spinal epidural hematoma (SEH) and analyze the reasons. The misdiagnosis was confirmed intraoperatively. Comprehensive analysis is crucial for the diagnosis of PSEA and its differential diagnosis from SEH.
Sheng‐Wei Meng, Qian Liu, Yong‐Sheng Zhao   +2 more
wiley   +1 more source

Efficacy of linezolid in the treatment of tuberculous meningitis: a meta-analysis

Introduction Tuberculous meningitis (TBM) is a severe extra-pulmonary tuberculosis with high fatality. This meta-analysis aimed to assess the impact of linezolid on TBM treatment outcomes.
Jian-Qing He, Min Qi, Xiaoshu Liu, Daoyan Tang   +3 more
core   +1 more source

Wide dissemination of linezolid-resistant Staphylococcus epidermidis in Greece is associated with a linezolid-dependent ST22 clone

, 2014
Objectives: Dependence on linezolid was recently described as significant growth acceleration of linezolidresistant Staphylococcus epidermidis (LRSE) isolates upon linezolid exposure.
Kimouli, M., Tsakris, A., Kousouli, E., Poulou, A., Ntokou, E., Hadjichristodoulou, C., Kristo, I., Carle, P., Kouskouni, E., Mamali, V., Vrioni, G., Dafopoulou, K., Papagiannakopoulou, P., Papanikolaou, P., Tsorlini, E., Themeli-Digalaki, K., Pournaras, S., Nepka, M., Stathoulopoulou, F., Stathopoulos, C., Zarkotou, O., Foudoulis, K., Karavasilis, V., Gennimata, V., Greek Study Group on Staphylococcal Linezolid Resistance, Kachrimanidou, M., Panopoulou, M., Stylianakis, A., Perivolioti, E.   +28 more
core   +1 more source

Utility of Metagenomic Next‐Generation Sequencing in Identifying Anaerobic Pathogens in a Pediatric Brain Abscess Secondary to Sinusitis: A Case Report

Clinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT In this pediatric brain abscess case, metagenomic next‐generation sequencing (mNGS) identified an anaerobic bacterium that remained undetected using conventional culture methods, thus providing clinically relevant information for antimicrobial management. This indicates that mNGS may be a useful adjunct for optimizing treatment strategies.
Risa Nagase, Kunihiro Oba, Mari Asakura, Masashi Ogasawara, Masahiro Noda, Yusuke Yamada, Asayo Furukawa, Naoki Kojima, Masanori Hashino, Kazuhiro Horiba   +9 more
wiley   +1 more source

Genetic Diversity and Epidemiological Overlap of Staphylococcus aureus at the Animal–Food–Environment–Human Interface Within a One Health Framework

MicrobiologyOpen, Volume 15, Issue 5, October 2026.
Integrating farm‐to‐fork and clinical surveillance, this study reveals distinct SCCmec distributions alongside shared spa types across human, animal, and food interfaces. The results of genetic diversity and epidemiological overlap underscore the critical need for coordinated One Health surveillance to monitor multi‐sectoral Staphylococcus aureus ...
Pinar Sagiroglu, Dursun Alp Gundog, Candan Gungor, Kursat Koskeroglu, Mustafa Altay Atalay, Adalet Dishan, Yeliz Ucar, Aytac Akcay, Huseyin Burak Disli, Harun Hizlisoy, Mukaddes Barel, Tekin Kececi, Nurhan Ertas Onmaz   +12 more
wiley   +1 more source

Safety of long-term use of linezolid: Results of an open-label study [PDF]

, 2016
Objective: The objective of this study was to assess the long-term safety of linezolid in patients with chronic infections requiring treatment for ≥6 weeks.
Swanson R. N., Vazquez, Jose A., Arnold, Anthony, Arnold AC, Vazquez J. A., Biswas, Pinaki, Biswas P., BASSETTI, MATTEO, Swanson, Robert N., Swanson RN, Swanson, Robert, Bassetti M, Kenreigh, Charlotte, Arnold A. C., Bassetti M., Vazquez JA, Arnold, Anthony C., Biswas P, Vazquez, Jose A   +18 more
core   +1 more source

Pharmacokinetics of PP353, a formulation of linezolid for intervertebral disc administration, in patients with chronic low back pain and Modic change Type 1: A first‐in‐human, Phase 1b, open‐label, single‐dose study

JOR Spine
Background Bacterial infection of the intervertebral disc is difficult to treat because the tissue is usually not vascularized and systemic antibiotic therapy may not reach optimal antibacterial exposure.
Shiva S. Tripathi, Robert Sneath, Aprajay Golash, Parag Desai, Duncan McHale, Sarah Guest, Charlie Brindley, Paul Cummings, Shane Smith, Conrad Stroud, Graham Scott, Steve Ruston, Lloyd Czaplewski   +12 more
doaj   +1 more source

Combined Use of Broad-Spectrum Antibiotics in Phthisiology

Фундаментальная и клиническая медицина
Aim. To investigate pharmacokinetic and pharmacodynamic interactions of levofloxacin, kanamycin and linezolid in combined chemotherapy of multidrug-resistant tuberculosis.Materials and Methods.
D. S. Vailenko, T. P. Tananakina, Yu. G. Pustovoy, V. V. Baranova, V. I. Shmatkov, A. R. Zanin   +5 more
doaj   +1 more source

Linezolid-induced black hairy tongue: a case report

Journal of Medical Case Reports, 2013
Introduction Linezolid-induced black hairy tongue has been rarely reported. The purpose of this paper is to report a case of linezolid-induced black hairy tongue and review the literature.
Khasawneh Faisal Abdullah, Moti Dereje Fikremariam, Zorek Joseph Anthony   +2 more
doaj   +1 more source