Results 121 to 130 of about 41,531 (223)

Population Pharmacokinetic/Pharmacodynamic Study of Linezolid in Hospital-Acquired Pneumonia Patients with Renal Insufficiency

Jin-hui Xu,1,* Xiang-long Chen,1,* Qian Zhang,1,* Zhiwei Zhuang,2 Yun-long Yuan,3 Lu-fen Duan,1 Lu Shi,1 Chenqi Zhu,1 Jing-Jing Li,1 Jian Lu,4 Yan-xia Yu,1 Lian Tang1,5 1Department of Pharmacy, The Affiliated Suzhou Hospital of Nanjing Medical University,
Duan L, Shi L, Li J, Tang L, Lu J, Chen X, Xu J, Zhang Q, Zhuang Z, Yuan Y, Zhu C, Yu Y   +11 more
core  

Guidelines for Essential Trauma Care: Second Edition (2026)

World Journal of Surgery, Volume 50, Issue 6, Page 1409-1450, June 2026.
Injury is a major cause of death and disability globally, with the highest burden in low‐ and middle‐income countries (LMICs). Strengthening the organization and planning for trauma care (care of the injured) can improve care and lower mortality. In 2004, the International Association for Trauma Surgery and Intensive Care (IATSIC) and the World Health ...
Charles Mock, Timothy C. Hardcastle, Christine Gaarder, Amit Gupta, Adam Gyedu, Manjul Joshipura, Elmin Steyn, on behalf of the Essential Trauma Care revision author group, Valencia Adjei, Roger Alcock, Vanda Amado, Michael Boampong, Sanjeev Booi, Petra Brysiewicz, Corazon Cabanilla‐Manuntag, Cristiane de Alencar Domingues, Ghada Elhadari, Ranjith Nanda Ellawala, Sarnai Erdene, Ama Akoma Essuman, Jorge Esteban Foianini, Filippo Gatti, Armando Garcia Guererra, Greg Hynes, Adil Haider, Sandy Ingless, Balavenkata Jagannathan, Helen Jowett, Knut Magne Kolstadbråten, Sonja Krofak, Aireen Patricia Madrid, Tina Tomić Mahečić, Claude Martin, Daniel Ntogwrachu, Bisola Onajin‐Obembe, Nhobojit Roy, Andres Rubiano, Niisoja Mensah Torto, Ben Wachira, Meg Walmsley, Torben Wisborg, Elma Wong   +41 more
wiley   +1 more source

Population Pharmacokinetic Model‐Based Optimization of Linezolid Dosing in Hematooncological Patients With Suspected or Proven Gram‐Positive Sepsis

Clinical and Translational Science
The objective of this study was to develop a population pharmacokinetic model for linezolid in hematooncological patients with sepsis, and to propose dosing optimization based on pharmacokinetic covariates that would lead to improved achievement of the ...
Alžběta Zavřelová, Sara Merdita, Pavel Žák, Jakub Radocha, Benjamin Víšek, Miriam Lánská, Jana Maláková, Pavel Michálek, Ondřej Slanař, Martin Šíma   +9 more
doaj   +1 more source

The protective role of vitamin C against linezolid-induced hepato-renal toxicity in a rat model

Frontiers in Pharmacology
This study investigated the protective effects of vitamin C against linezolid-induced hepatotoxicity and nephrotoxicity in rats using biochemical, histopathological, and immunohistochemical methods. Twenty-four rats were divided into four groups: control,
Shaimaa M. Azzam, Hend Mohamed Anwar, Ahmed H. Abd El-Slam, Marwa S. M. Diab, Halima Mohamed Ibrahim, Abdalrahman Mohammed Yousef, Fatma Mahmoud Sabry, Ibrahim A. Darwish, Kalidasan Kaliyamoorthy, Gad Elsayed Mohamed Salem, Heba M. A. Elsanhory   +10 more
doaj   +1 more source

Wide dissemination of linezolid-resistant Staphylococcus epidermidis in Greece is associated with a linezolid-dependent ST22 clone

, 2015
Objectives: Dependence on linezolid was recently described as significant growth acceleration of linezolid-resistant Staphylococcus epidermidis (LRSE) isolates upon linezolid exposure.
Zarkotou, O., Karavasilis, V., Gennimata, V., Tsakris, A., Kachrimanidou, M., Themeli-Digalaki, K., Pournaras, S., Greek Study Grp Staphylococcal, Lin, Panopoulou, M., Stylianakis, A., Ntokou, E., Stathopoulos, C.   +11 more
core   +1 more source

High Resistance and Biofilm Tolerance to Antimicrobials of Marine Bacteria From Brazilian Deep‐Sea Sediment

Environmental Microbiology Reports, Volume 18, Issue 3, June 2026.
Antimicrobial resistance and biofilm‐specific tolerance of cultivable Pseudomonas, Bacillus, Brevibacillus and Paenibacillus isolated from deep‐sea sediments of a methane‐seep area off the Southern Brazilian coast. These findings underscore the role of deep‐sea environments as potential reservoirs for antimicrobial‐resistant bacteria (ARB) and ...
Amanda Simão Dias, Sílvia Dias de Oliveira, Renata Medina‐Silva   +2 more
wiley   +1 more source

Altered Pathogen Spectrum of Spontaneous Bacterial Peritonitis in Patients Treated With Proton Pump Inhibitors

Alimentary Pharmacology &Therapeutics, Volume 63, Issue 11, Page 1487-1494, June 2026.
This multicenter, observational study reveals distinct alterations in the microbial spectrum of spontaneous bacterial peritonitis (SBP) associated with proton pump inhibitor use. These results are especially relevant for guiding empiric antibiotic therapy of SBP.
Philip Kitchen, Sarah L. Schütte, Tammo L. Tergast, Benjamin Maasoumy, Leonie Braun, Ulrich vor dem Esche, Georg Häcker, Marcus M. Mücke, Marlene Reincke, Michael Schultheiss, Robert Thimme, Siegbert Rieg, Dominik Bettinger, Lukas Sturm   +13 more
wiley   +1 more source

Protective Effect of Exogenous Adenosine Triphosphate Against Ocular Toxicity of Linezolid in Rats

Life
Linezolid, a synthetic antimicrobial agent, may induce oxidative damage in ocular tissues, particularly in the optic nerve. Adenosine triphosphate (ATP) is involved in the production of antioxidants that scavenge and neutralize reactive oxygen species ...
Cenap Mahmut Esenulku, Ibrahim Cicek, Ahmet Mehmet Somuncu, Bulent Yavuzer, Esra Tuba Sezgin, Tugba Bal Tastan, Nurinisa Yücel, Ezgi Karatas, Halis Suleyman   +8 more
doaj   +1 more source

Linezolid resistant Staphylococcus aureus

, 2017
Linezolid is the only antibiotic available as an oral formulation for resistant staphylococcal infections. It is effective in skin & soft tissue infections, nosocomial pneumonias including VAP, infective endocarditis and MRSA meningitis.
Gandham, Pavani
core  

Burn Wound Infections With Staphylococcus aureus: Clinical Characteristics and Risk Factors for Methicillin‐Resistant Strains

International Wound Journal, Volume 23, Issue 6, June 2026.
ABSTRACT This study aimed to systematically delineate the clinical characteristics and identify the key risk factors associated with methicillin‐resistant Staphylococcus aureus (MRSA) infections in burn patients, thereby informing targeted preventive measures and therapeutic strategies.
Xiaolan Hong, Shaobo Zhou, Qinghua Cai, Yuanyuan Cai, Zhaohong Chen, Wanting Zhao, Yongjian Ye, Xubo Dai   +7 more
wiley   +1 more source