Results 91 to 100 of about 60,035 (201)

Tetrahydropyrazolo[1,5-a]Pyrimidine-3-Carboxamide and N-Benzyl-6′,7′-Dihydrospiro[Piperidine-4,4′-Thieno[3,2-c]Pyran] analogues with bactericidal efficacy against Mycobacterium tuberculosis targeting MmpL3 [PDF]

, 2013
Mycobacterium tuberculosis is a major human pathogen and the causative agent for the pulmonary disease, tuberculosis (TB). Current treatment programs to combat TB are under threat due to the emergence of multi-drug and extensively-drug resistant TB.
A Hill, A Koul, AE Grzegorzewicz, Alfonso Mendoza-Losana, Anil Kumar Tyagi, C Dye, C Varela, Carlos Alemparte, Carolina González, Chrystala Constantinidou, CK Stover, David Barros, David J. Dow, DJ Payne, Douglas J. Minick, Elena Jiménez, Esther Pérez-Herrán, Fátima Ortega-Muro, Gurdyal S. Besra, Iñigo Angulo-Barturen, JA Maddry, Joaquín Rullás, Johnson Afari, Jorge Esquivias, K Andries, K Pethe, K Tahlan, LL Ballell, Lluís Ballell, M Berry, M Biava, M Murray, M Protopopova, Mark J. Pallen, María José Rebollo-López, María Martínez-Hoyos, María Teresa Fraile-Gabaldón, Modesto J. Remuiñán, Mónica Cacho, Nalini Mehta, Nicholas Cammack, Nicholas J. Loman, R Singh, SA Stanley, ST Cole, V La Rosa, V Makarov, Verónica Sousa, Vickey L. Spivey   +48 more
core   +3 more sources

Combined Use of Broad-Spectrum Antibiotics in Phthisiology

Фундаментальная и клиническая медицина
Aim. To investigate pharmacokinetic and pharmacodynamic interactions of levofloxacin, kanamycin and linezolid in combined chemotherapy of multidrug-resistant tuberculosis.Materials and Methods.
D. S. Vailenko, T. P. Tananakina, Yu. G. Pustovoy, V. V. Baranova, V. I. Shmatkov, A. R. Zanin   +5 more
doaj   +1 more source

The distribution of plasmids that carry virulence and resistance genes in Staphylococcus aureus is lineage associated. [PDF]

, 2012
BACKGROUND: Staphylococcus aureus is major human and animal pathogen. Plasmids often carry resistance genes and virulence genes that can disseminate through S. aureus populations by horizontal gene transfer (HGT) mechanisms. Sequences of S.
Lindsay, JA, McCarthy, AJ
core   +2 more sources

Pharmacokinetics of PP353, a formulation of linezolid for intervertebral disc administration, in patients with chronic low back pain and Modic change Type 1: A first‐in‐human, Phase 1b, open‐label, single‐dose study

JOR Spine
Background Bacterial infection of the intervertebral disc is difficult to treat because the tissue is usually not vascularized and systemic antibiotic therapy may not reach optimal antibacterial exposure.
Shiva S. Tripathi, Robert Sneath, Aprajay Golash, Parag Desai, Duncan McHale, Sarah Guest, Charlie Brindley, Paul Cummings, Shane Smith, Conrad Stroud, Graham Scott, Steve Ruston, Lloyd Czaplewski   +12 more
doaj   +1 more source

Linezolid-induced Black Hairy Tongue

Journal of Association of Pulmonologist of Tamil Nadu
Linezolid is an effective multidrug-resistant anti-tubercular drug. However, the use of linezolid has been associated with multiple side effects. One of the rare side effects is linezolid-induced black hairy tongue, which is a benign and self-limiting ...
M. Natraj, T. Anbarasan
doaj   +1 more source

Evaluation of the rational prescription of linezolid, the prevalence of thrombocytopenia and major drug interactions in patients with cardiovascular diseases: are there any cautions?

Journal of Pharmacy & Pharmaceutical Sciences
The present study evaluated the rational prescription of linezolid, the prevalence of thrombocytopenia, and major drug interactions in patients with cardiovascular diseases. We conducted a retrospective cross-sectional study on linezolid-treated patients
Mehrnoush Dianatkhah, Mehrnoush Dianatkhah, Hamed Salami, Rasool Soltani, Alireza Hosseini   +4 more
doaj   +1 more source

New and Improved Diagnostics for Detection of Drug-Resistant Pulmonary Tuberculosis. [PDF]

, 2011
PURPOSE OF REVIEW: Tuberculosis (TB) remains a global emergency and continues to kill 1.7 million people globally each year. Drug-resistant TB is now well established throughout the world and most TB patients are not being screened for drug resistance ...
Affolabi, Albert, Banerjee, Blakemore, Boehme, Brossier, Bwanga, Caws, Coronel, Drews, Ellner, Ellner, Farnia, Fears, Garza-González, Gupta, Helb, Hillemann, Kiet, Kim, Lemaire, Lin, Ling, Martin, Martin, Martin, Migliori, Migliori, Minion, Morcillo, Neonakis, Nicol, Pai, Palomino, Piersimoni, Sandgren, Sohn, Van Rie, Visalakshi, Visalakshi, Wallis, Wright   +41 more
core   +1 more source

The Surgical Infection Society revised guidelines on the management of intra-abdominal infection [PDF]

, 2017
Background: Previous evidence-based guidelines on the management of intra-abdominal infection (IAI) were published by the Surgical Infection Society (SIS) in 1992, 2002, and 2010. At the time the most recent guideline was released, the plan was to update
Chang, Phillip K, Diaz, Jose J, Jr, Huston, Jared M, May, Addison K, Mazuski, John E, Mollen, Kevin P, Nadler, Evan P, O\u27Neill, Patrick J, Prince, Jose M, Rosengart, Matthew R, Sawyer, Robert G, Tessier, Jeffrey M   +11 more
core   +3 more sources

Efficacy, safety, tolerability and population pharmacokinetics of tedizolid, a novel antibiotic, in Latino patients with acute bacterial skin and skin structure infections

Brazilian Journal of Infectious Diseases, 2016
Acute bacterial skin and skin structure infections are caused mainly by Gram-positive bacteria which are often treated with intravenous vancomycin, daptomycin, or linezolid, with potential step down to oral linezolid for outpatients.
Alejandro Ortiz-Covarrubias, Edward Fang, Philippe G. Prokocimer, Shawn D. Flanagan, Xu Zhu, Jose Francisco Cabré-Márquez, Toshiaki Tanaka, Julie Passarell, Jill Fiedler-Kelly, Esteban C. Nannini   +9 more
doaj   +1 more source

The Effect of Linezolid Therapy Duration on The Occurrence of Toxic Optic Neuropathy

Aksona
Highlight: • The occurence of toxic optic neuropathy in this study was similar to the occurence of anemia. • Discontinuation of Linezolid therapy improves visual disturbance • Linezolid therapy duration to cause TON in this study varies ...
Quinamora Estevan Sutantyo, Lukisiari Agustini, Tutik Kusmiati, Ariani Permatasari   +3 more
doaj   +1 more source