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Quantification of CGRP‐immunoreactive myenteric neurons in mouse colon
Journal of Comparative Neurology, 2022Abstract Quantitative data of biological systems provide valuable baseline information for understanding pathology, experimental perturbations, and computational modeling. In mouse colon, calcitonin gene‐related peptide (CGRP) is expressed by myenteric neurons with multiaxonal (Dogiel type II) morphology ...
Timothy J. Hibberd +8 more
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Quantification of neurons in the myenteric plexus: an evaluation of putative pan-neuronal markers
Journal of Neuroscience Methods, 2004Accurate estimates of the total number of neurons located in the wall of the gut are essential for studies of the enteric nervous system (ENS). Though several stains and antibodies are used routinely as pan-neuronal markers, controversies of relative sensitivity and completeness have been difficult to resolve, at least in part because comparisons often
Robert J, Phillips +4 more
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Effects of capsaicin on myenteric neurons of the guinea pig ileum
Neuroscience Letters, 1989The effects of capsaicin on the electrophysiological behavior of myenteric neurons were investigated with intracellular recording techniques in the isolated guinea pig ileum. Capsaicin evoked a marked long-lasting slow depolarization associated with increased input resistance, during which the cells spiked repeatedly or displayed anodal break ...
M, Takaki, S, Nakayama
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The effect of bradykinin on the electrical activity of rat myenteric neurons
European Journal of Pharmacology, 2014Bradykinin is a mediator involved in inflammatory processes in the gut. Here we investigated the effect of bradykinin on the electrical activity of rat myenteric neurons, the key players for regulation of gastrointestinal motility. Bradykinin (2 × 10(-8)mol/l) induced a biphasic increase in frequency of action potentials measured with microelectrode ...
Lisa, Würner +2 more
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Neuroligands evoke calcium signaling in cultured myenteric neurons*
Surgery, 1995Myenteric neurons, which control gut motility and absorption, are heterogeneous in structure, electrophysiology, and neuropeptide content. We hypothesized that myenteric neurons would display heterogeneous responses to neuroligands found in enteric tissue.
B C, Kimball, M W, Mulholland
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GABAergic Neurons in the Myenteric Plexus
1992Some 20 years ago, Hobbiger [8] speculated on the basis of pharmacological studies that GABA, then recently discovered as a constituent of nervous tissue, might have a role in neurotransmission in the enteric nervous system of the vertebrate gut. Subsequent work, however, soon focussed on GABA in relation to the vertebrate central nervous system ...
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Afterhyperpolarization Current in Myenteric Neurons of the Guinea Pig Duodenum
Journal of Neurophysiology, 2001Whole cell patch and cell-attached recordings were obtained from neurons in intact ganglia of the myenteric plexus of the guinea pig duodenum. Two classes of neuron were identified electrophysiologically: phasically firing AH neurons that had a pronounced slow afterhyperpolarization (AHP) and tonically firing S neurons that lacked a slow AHP.
F, Vogalis, J B, Furness, W A, Kunze
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Neurochemical coding of myenteric neurones in the human gastric fundus
Neurogastroenterology & Motility, 2003Abstract The major functions of the stomach are under the control of the enteric nervous system (ENS), but the neuronal circuits involved in this control are largely unknown in humans. Enteric neurones can be characterized by their neuromediator or marker content, i.e. by neurochemical coding. The purpose of this study was to characterize the presence
S, Pimont +5 more
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Mast cells reduce survival of myenteric neurons in culture
Neuropharmacology, 2009Mast cell-nerve interactions play a key role in intestinal inflammation and irritable bowel disease. Loss of enteric neurons has been reported in inflammatory conditions but the contribution of mast cells in this event is unknown. To study neuronal survival and plasticity of myenteric neurons in contact with mast cells a co-culture system using ...
Elin, Sand +2 more
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Neurochemical coding of myenteric neurons in the guinea-pig antrum
Cell and Tissue Research, 1999Electrophysiological studies of myenteric neurons in the guinea-pig antrum suggest that different neuroactive compounds are involved in synaptic transmission. It is not known what neurotransmitters and neuropeptides are present and to what extent they colocalize. Immunohistochemical stainings were performed on whole-mount preparations of the guinea-pig
Vanden Berghe, P. +5 more
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