Results 91 to 100 of about 18,192 (271)

Pyroptosis in Peripheral Neuropathy: From Molecular Mechanisms to Therapeutic Targeting

CNS Neuroscience &Therapeutics, Volume 32, Issue 1, January 2026.
Pyroptosis is a key inflammatory cell death pathway in peripheral neuropathy, with opposing roles: it perpetuates neuropathic pain but can be induced to kill neuroblastoma cells. This review consolidates mechanistic understanding and therapeutic strategies, arguing for a shift from disease‐centric to target‐centric treatment approaches to improve ...
Jinhuan Wei, Mingyue Liuyuan, Zhixin Ye, Xueying Wang, Xueli Zhou, Yifan Shan, Cheng He, Chunting Zhu, Chicheng Zhou, Jingyin Bao, Yonghui Zhang, Gang Chen   +11 more
wiley   +1 more source

Postnatal development of nitric oxide synthase-expressing neurones in the enteric nervous system of the goat

Italian Journal of Animal Science, 2010
The morphology and distribution of nitric oxide synthase (NOS)-expressing neurons in the myenteric plexus of small intestine of goat at different ages (2 weeks, and 2, 4, 6 and 12 months) were studied by using nicotinamide adenine dinucleotide phosphate ...
Zixu Wang, Yaoxing Chen, Liujun Jia, Yunfang Liu   +3 more
doaj   +1 more source

Alpha‐Ketoglutarate Regulates Intestinal Motility and Health by OXGR1 in Nitrergic Neuron of Enteric Nervous System

Food Frontiers, Volume 7, Issue 1, January 2026.
ABSTRACT Intestinal health could be affected by intestinal motility, which is controlled by the enteric nervous system. In this study, we found that α‐ketoglutarate (AKG) inhibits intestinal motility and improves intestinal permeability, accompanied by an increased count of intestinal flora.
Guli Xu, Jingjing Zhou, Pingwen Xu, Ishwari Gyawali, Chang Xu, Jinping Yang, Zewei Ma, Dan Du, Qingyan Jiang, Gang Shu   +9 more
wiley   +1 more source

Waardenburg syndrome with isolated deficiency of myenteric ganglion cells at the sigmoid colon and rectum

Pediatric Reports, 2018
Waardenburg syndrome (WS) has the characteristic clinical features caused by the embryologic abnormality of neural crest cells. WS patients sometimes suffer from functional intestinal obstruction. When it is Hirschsprung disease (HD), the WS is diagnosed
Shun Watanabe, Shotaro Matsudera, Takeshi Yamaguchi, Yukiko Tani, Kei Ogino, Masanobu Nakajima, Satoru Yamaguchi, Kinro Sasaki, Hiroshi Suzumura, Takashi Tsuchioka   +9 more
doaj   +1 more source

Expression and function of the bile acid receptor GpBAR1 (TGR5) in the murine enteric nervous system [PDF]

, 2010
BACKGROUND: Bile acids (BAs) regulate cells by activating nuclear and membrane-bound receptors. G protein coupled bile acid receptor 1 (GpBAR1) is a membrane-bound G-protein-coupled receptor that can mediate the rapid, transcription-independent actions ...
Armstrong, Bouscarel, Cabral, Camilleri, Claudel, Dawson, Falconer, Feldman, Furness, Gupta, Karlstrom, Karlstrom, Katsuma, Kawamata, Keitel, Keitel, Keitel, Keitel, Khurana, Kirwan, Lefebvre, Liu, Looby, Makishima, Maruyama, Maruyama, Mascolo, Monte, Penagini, Penagini, Poole, Qiao, Qu, Raufman, Romero, Sato, Spiller, Staudinger, Van Ooteghem, Wang, Watanabe   +40 more
core   +1 more source

Altered Levels of Enteric Glial Cells and Their Associated Pro‐Inflammatory Proteins in Patients With Ulcerative Colitis During Active Disease Compared to Remission and Healthy Controls

JCC Plus, Volume 1, Issue 1, January 2026.
This study investigates alterations in enteric glial cells and their associated pro‐inflammatory proteins in ulcerative colitis. Paired mucosal biopsies from inflamed and non‐inflamed segments of patients during clinically active disease and remission were compared with healthy controls.
Julie Beaudeau, Georgios Katinios, Carl Mårten Lindqvist, Susanna A. Walter, Simone Ignatova, Olga Bednarska, Andreas Münch, Johan D. Söderholm, Jonas Halfvarson, Benita Salomon, Ida Schoultz, Henrik Hjortswang, Åsa V. Keita   +12 more
wiley   +1 more source

Further Insights Into Anticholinergic Action Informed by Japanese Anticholinergic Risk Scale

Geriatrics &Gerontology International, Volume 26, Issue 1, January 2026.
ABSTRACT The increased anticholinergic burden caused by medications in older adults is one of the adverse drug reactions of particular concern, as it can exacerbate the onset of geriatric syndromes or induce cognitive dysfunction, and is also related to the issue of polypharmacy.
Masaki Mogi, Shuang Liu, Yasuyuki Suzuki, Yuuka Shibata, Shizuo Yamada   +4 more
wiley   +1 more source

The Enteric Nervous System as a Mediator of Microbiota‐Gut‐Brain Interactions in Parkinson's Disease

Journal of Neurochemistry, Volume 170, Issue 1, January 2026.
Parkinson's disease (PD) is a neurodegenerative disorder that is increasingly recognized as a gut‐brain disorder, involving gut dysfunction before the onset of motor symptoms. While many studies have focused on changes in gut microbiota, inconsistent results highlight the limitations of viewing PD through a microbiota‐only lens.
Luisa Valdetaro, Maria Carolina Ricciardi, Patricia Pereira Almeida, Milena Barcza Stockler‐Pinto, Ana Lucia Tavares‐Gomes   +4 more
wiley   +1 more source

Spontaneous enteric nervous system activity generates contractile patterns prior to maturation of gastrointestinal motility

Neurogastroenterology &Motility, Volume 38, Issue 1, January 2026.
Spontaneous neuronal network activity is critical for circuit maturation, yet whether this is a feature of enteric nervous system development has yet to be established. Here, we identify clustered ripples, a previously undescribed form of neurogenic gastrointestinal motility that shares many features with spontaneous neuronal networks in other systems.
Lori B. Dershowitz, Hassler Bueno Garcia, Andrew S. Perley, Todd P. Coleman, Julia A. Kaltschmidt   +4 more
wiley   +1 more source

P85 | ALTERATION OF SUBMUCOSAL AND MYENTERIC GANGLIA IN SEVERE GUT DYSMOTILITY: A QUANTITATIVE MORPHOMETRIC ANALYSIS

European Journal of Histochemistry
Severe gut dysmotility (SD) is marked by impaired gut propulsion and distinct histopathological features, including fewer myenteric and submucosal neurons per ganglion and increased interganglionic distance. However, neurons counting remains complex and
doaj   +1 more source