Results 21 to 30 of about 18,192 (271)

Intestinal Region-Dependent Alterations of Toll-Like Receptor 4 Expression in Myenteric Neurons of Type 1 Diabetic Rats

Biomedicines, 2023
Toll-like receptor 4 (TLR4) can activate pro-inflammatory cascades in the gastrointestinal tract. Our aim was to determine TLR4 expression in myenteric neurons of different gut regions using a type 1 diabetic model.
Nikolett Bódi, Abigél Egyed-Kolumbán, Benita Onhausz, Bence Pál Barta, Afnan AL Doghmi, János Balázs, Zita Szalai, Mária Bagyánszki   +7 more
doaj   +1 more source

scRNA-Seq Reveals New Enteric Nervous System Roles for GDNF, NRTN, and TBX3Summary

Cellular and Molecular Gastroenterology and Hepatology, 2021
Background and Aims: Bowel function requires coordinated activity of diverse enteric neuron subtypes. Our aim was to define gene expression in these neuron subtypes to facilitate development of novel therapeutic approaches to treat devastating enteric ...
Christina M. Wright, Sabine Schneider, Kristen M. Smith-Edwards, Fernanda Mafra, Anita J.L. Leembruggen, Michael V. Gonzalez, Deepika R. Kothakapa, Jessica B. Anderson, Beth A. Maguire, Tao Gao, Tricia A. Missall, Marthe J. Howard, Joel C. Bornstein, Brian M. Davis, Robert O. Heuckeroth   +14 more
doaj   +1 more source

Changes in neuromuscular structure and functions of human colon during ageing are region-dependent [PDF]

, 2018
Objective: To determine if human colonic neuromuscular functions decline with increasing age.Design: Looking for non-specific changes in neuromuscular function, a standard burst of electrical field stimulation (EFS) was used to evoke neuronally mediated (
Ahmed, Shafi, Broad, John, Carroll, Rebecca, Chin-Aleong, Joanne, Darreh-Shori, Taher, Elahi, Shezan, Karami, Azadeh, Knowles, Charles H., Kung, Victor W. S., Martin, Joanne E., Palmer, Alexandra, Saffrey, M. Jill, Sanger, Gareth John, Thaha, Mohamed Adhnan   +13 more
core   +2 more sources

Enteric Neurospheres Are Not Specific to Neural Crest Cultures: Implications for Neural Stem Cell Therapies [PDF]

, 2015
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work ...
A Barlow, A Pini Prato, A Zani, AG Baynash, AG Catto-Smith, AJ Burns, AJ Burns, Alan J. Burns, AS Wallace, C Caldwell, C Kalcheim, C Laranjeira, CH Knowles, Conor McCann, D Natarajan, Dipa Natarajan, DM Rodrigues, E Panza, Ellen Binder, GE Boeckxstaens, H Tsuji, HM Pallari, J Amiel, Jean-Marie Delalande, Julie Cooper, L Becker, L Ludman, M Hanani, M Metzger, Mara Cananzi, MC Nunes, MD Gershon, Mirella Dottori, MP Sanchez, MT Liu, N Bondurand, N Nagoshi, N Thapar, Nikhil Thapar, NR Druckenbrod, PS Danielian, R Hotta, R Hotta, R Zufferey, Rania Kronfli, RC Mifflin, RM Lindley, S Almond, S Bixby, S Hetz, S Srinivas, S Theocharatos, SJ Conway, SJ Howe, SJ McKeown, TA Heanue, TP Rothman, U Rauch, V Sasselli, X Jiang, Y Matsuda, YH Tsai   +61 more
core   +9 more sources

Toll-Like Receptor 4 Modulates Small Intestine Neuromuscular Function through Nitrergic and Purinergic Pathways [PDF]

, 2017
Objective: Toll-like receptors (TLRs) play a pivotal role in the homeostatic microflora-host crosstalk. TLR4-mediated modulation of both motility and enteric neuronal survival has been reported mainly for colon with limited information on the role of ...
Cecilia Giulivi, Cecilia Giulivi, Eleonora Napoli, Francesca Galuppini, Genny Orso, Ilaria Marsilio, Isabella Lante, Maria Cecilia Giron, Massimo Rugge, Mona Roozfarakh, Silvia Cerantola, Silvia Cerantola, Valentina Caputi   +12 more
core   +3 more sources

Three distinct classes of myenteric ganglia in mice and humans: insights from quantitative analyses [PDF]

PeerJ
Background The myenteric plexus primarily consists of the myenteric ganglia, which include enteric neurons, synaptic neuropils, and glial cells. Abnormal myenteric plexus formation can result in gastrointestinal disorders.
Luyao Wu, Lei Xiang, Yingjian Chen, Handan Mao, Xinyao Meng, Jing Wang, Honglin Li, Xuyong Chen, Jiexiong Feng, Jun Xiao   +9 more
doaj   +2 more sources

Intestinal Region-Specific and Layer-Dependent Induction of TNFα in Rats with Streptozotocin-Induced Diabetes and after Insulin Replacement

Cells, 2021
Tumour necrosis factor alpha (TNFα) is essential in neuroinflammatory modulation. Therefore, the goal of this study is to reveal the effects of chronic hyperglycaemia and insulin treatment on TNFα expression in different gut segments and intestinal wall ...
Nikolett Bódi, Lalitha Chandrakumar, Afnan al Doghmi, Diána Mezei, Zita Szalai, Bence Pál Barta, János Balázs, Mária Bagyánszki   +7 more
doaj   +1 more source

Myenteric plexus abnormalities associated with epiphrenic diverticula☆ [PDF]

European Journal of Cardio-Thoracic Surgery, 2009
To (1) categorize histologic esophageal myenteric plexus abnormalities in patients undergoing surgical treatment for epiphrenic diverticulum, and (2) correlate histologic changes with associated esophageal motility disorders and hiatal hernia.From January 1987 to May 2008, 40 patients had surgery for epiphrenic diverticulum.
Thomas W, Rice, John R, Goldblum, Martha M, Yearsley, Steven S, Shay, Scott I, Reznik, Sudish C, Murthy, David P, Mason, Eugene H, Blackstone   +7 more
openaire   +2 more sources

Effects of caerulein on the gastric motility of rats. [PDF]

, 1985
The effects of caerulein on gastric motility in urethane-anesthetized rats were studied. Caerulein administered into the lateral cerebral ventricle (i.c.v.) and jugular vein (i.v.) caused predominantly an inhibitory effect on gastric motility but ...
Jin, Ze-Zhong, Nakayama, Sosogu, Neya, Toshiaki   +2 more
core   +1 more source

Quantification of the neurons of myenteric plexus of the bat molossus rufus [PDF]

Pesquisa Veterinária Brasileira
: There are no studies that characterize the enteric nervous system (ENS) bats. The organization and density of myenteric neurons may vary according to the animal species, as well as the segment of the digestive tube considered.
Grazielli F. Serenini, José Matheus Beltrami, Edson Gerônimo, Paula M. Favetta, Nathalia G.E. Legnani, Luciana K. Otutumi, Lisiane A. Martins, Ricardo M. Germano   +7 more
doaj   +2 more sources