Results 1 to 10 of about 10,831 (110)

Hypoxia induced DNMT3B and SHP2 signaling promoted HCC via suppressing P53 and MYH11 protein expression [PDF]

Frontiers in Oncology
ObjectiveThis work aims to analyze the intricate process via which CBFβ-MYH11 facilitates the suppression of hepatocellular carcinoma in hypoxic environments.MethodsThree independent HCC cohorts including TCGA-LIHC, GSE14520 and ICGC LIRI-JP were ...
Hongxun Ruan, Wei Huang, Yanle Fang, Ling Xie, Xiaoning Qin   +4 more
doaj   +2 more sources

Novel MYH11::GLI3 fusion in ileal leiomyoma [PDF]

Pathology and Oncology Research
BackgroundLeiomyomas of the gastrointestinal tract (GI) are benign smooth muscle neoplasms with limited genetic characterization. Molecular investigations may improve diagnostic classification and enhance understanding of their biological behavior ...
Ioannis Panagopoulos, Ioannis Panagopoulos, Ingvild Lobmaier   +2 more
doaj   +2 more sources

An exploratory analysis of disulfidptosis-related gene signatures in minimal change disease identifies metabolic and immune associations [PDF]

Frontiers in Cell and Developmental Biology
AimWe aimed to investigate the association between genes related to disulfidptosis—a form of cell death caused by aberrant disulfide stress and cytoskeletal collapse—and the molecular features of minimal change disease (MCD), the leading cause of primary
Jiahui Li, Jiahui Li, Quhuan Li, Yue Shen, Chaohong Nie, Jiao Li, Fengxia Zhang, Fengxia Zhang   +7 more
doaj   +2 more sources

Concomitant Clonal CBFB::MYH11 and PDGFRB Fusions in a Case of De Novo Acute Myeloid Leukemia [PDF]

Hematology Reports
Background: Acute myeloid leukemia (AML) with CBFB::MYH11 fusion and myeloid/lymphoid neoplasms with eosinophilia and tyrosine kinase gene fusions (MLN-TK) are genetically defined and typically mutually exclusive entities.
Qiliang Ding, Natasha E. Lewis, Cody J. Artymiuk, Renee M. Olson, Rong He, Rhett P. Ketterling, David S. Viswanatha, Patricia T. Greipp, Cinthya J. Zepeda Mendoza   +8 more
doaj   +2 more sources

A tRNA-derived fragment tRF3019a promotes LUAD metastasis by stabilizing hnRNPK and enhancing MYH11 expression [PDF]

Cellular & Molecular Biology Letters
Background tRNA-derived fragments (tRFs) have been shown to play important regulatory roles in cancer biology. However, the impact of tRFs on lung adenocarcinoma (LUAD) remains largely unexplored.
Xin Li, Weifang Cui, Zhangjie Wang, Danyao Chen, Zhenyu Kuang, Junjie Jiang, Yuwei Lai, Xiongzhou Zhang, Chaojun Duan, Chunfang Zhang, Xizhe Li   +10 more
doaj   +2 more sources

Case Report: Diagnostic odyssey in rare diseases: when genetic variants are misinterpreted [PDF]

Frontiers in Pediatrics
IntroductionThe diagnostic odyssey in rare diseases often involves the misinterpretation of genetic data, particularly when multidisciplinary approaches are lacking.
Minerva Montero-Hernández, Minerva Montero-Hernández, Nahuel Pérez-Moix, Nahuel Pérez-Moix, María-Carmen Carrascosa-Romero, María-Pilar López-Garrido, María-Pilar López-Garrido, Francisco Sánchez-Sánchez, Francisco Sánchez-Sánchez   +8 more
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Exon skipping as a potential diagnostic biomarker in colorectal cancer: an integrated epigenomic-transcriptomic analysis​ [PDF]

Human Genomics
Background Colorectal cancer (CRC) is the third most common cancer globally. Alternative splicing contributes significantly to CRC tumorigenesis through aberrant transcript generation.
Lili Zhang, Jian Cui, Jinxin Shi, Jiahui Cai, Tianhan Sun, Gaoyuan Sun, Yifei Li, Hexin Li, Siyuan Xu, Xiaokun Tang, Ziwei Chen, Hongyuan Cui, Fei Xiao, Gang Zhao   +13 more
doaj   +2 more sources

Differential phenotypes in mice with smooth muscle-specific heterozygous versus homozygous deletion of Stk11 [PDF]

Scientific Reports
Liver kinase B1 (Lkb1), encoded by the serine/threonine kinase gene STK11, functions as a critical tumor suppressor associated with Peutz-Jeghers syndrome (PJS).
Haiping Chen, Guifeng Zhang, Yangjing Jiang, Min Liang, Yijie Huang, Liang Fang, Long Chen, Danrui Xiao, Yunwen Hu, Ben He, Zhaohua Cai   +10 more
doaj   +2 more sources

Progerin mislocalizes myocardin-related transcription factor in Hutchinson–Guilford Progeria syndrome

Vascular Biology, 2022
Hutchinson–Guilford Progeria syndrome (HGPS) is a rare genetic disease of premature aging and early death due to cardiovascular disease. The arteries of HGPS children and mice are pathologically stiff, and HGPS mice also display reduced arterial ...
Ryan von Kleeck, Paola Castagnino, Richard K Assoian   +2 more
doaj   +1 more source

Interaction between DNMT3B and MYH11 via hypermethylation regulates gastric cancer progression

BMC Cancer, 2021
Background Gastric cancer (GC) has an unwelcoming prognosis when diagnosed at an advanced stage. The purpose of this study was to examine the expression of myosin heavy chain 11 (MYH11) in GC and mechanisms related. Methods The MYH11 expression in GC was
Jianhua Wang, Ping Xu, Yanping Hao, Tingting Yu, Limin Liu, Yan Song, Yan Li   +6 more
doaj   +1 more source