Results 11 to 20 of about 10,859 (138)
Brazilian Journal of Medical and Biological Research, 2021 Inv(16)(p13.1q22) in acute myeloid leukemia (AML) is a common chromosomal abnormality. It leads to the core-binding factor ß-subunit (CBFβ)/smooth muscle myosin heavy chain 11 (MYH11) fusion gene.
Wenyi Zhang +5 more
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Scientific Reports, 2022 Pathogenic variants in myosin heavy chain (Myh11) cause familial thoracic aortic aneurysms and dissections (FTAAD). However, the underlying pathological mechanisms remain unclear because of a lack of animal models.
Keita Negishi +16 more
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CBFB-MYH11 Fusion Sequesters RUNX1 in Cytoplasm to Prevent DNMT3A Recruitment to Target Genes in AML
Frontiers in Cell and Developmental Biology, 2021 A growing number of human diseases have been found to be associated with aberrant DNA methylation, including cancer. Mutations targeting genes encoding DNA methyltransferase (DNMT), TET family of DNA demethylases, and isocitrate dehydrogenase (IDH1, IDH2)
Peng Liu +10 more
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Genetic approaches to identify pathological limitations in aortic smooth muscle contraction. [PDF]
PLoS ONE, 2018 Aortic smooth muscle contains limiting amounts of myosin light chain kinase (MLCK) for myosin regulatory light chain (RLC) phosphorylation and contraction that predisposes to thoracic aortic disease in humans containing heterozygous loss-of-function ...
Jian Huang +5 more
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Frontiers in Pediatrics, 2022 BackgroundThe distribution of RUNX1-RUNXT1, PML-RARA, CBFB-MYH11, BCR-ABL1p210, and KMT2A-MLLT3 in the pediatric population with acute myeloid leukemia (AML) in many countries of Latin America is largely unknown.
Omar Sepúlveda-Robles +32 more
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Matrix Biology Plus, 2021 Of the many origins of pulmonary myofibroblasts, microvascular pericytes are a known source. Prior literature has established the ability of pericytes to transition into myofibroblasts, but provide limited insight into molecular cues that drive this ...
Riley T. Hannan +5 more
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Generating endogenous Myh11-driven Cre mice for sex-independent gene deletion in smooth muscle cells
JCI Insight, 2023 Specific and efficient smooth muscle cell–targeted (SMC-targeted) gene deletion is typically achieved by pairing SMMHC-CreERT2-Tg mice with mice carrying the loxP-flanked gene.
Yang Zhao +11 more
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Genome-wide binding of transcription factors in inv(16) acute myeloid leukemia
Genomics Data, 2014 The inv(16) translocation is associated with 5% of AML cases and gives rise to expression of the oncofusion protein CBFβ-MYH11. Although different molecular mechanisms for the oncogenic activity of this fusion protein have been proposed these were mostly
A. Mandoli, K. Prange, J.H.A. Martens
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Human Pathology: Case Reports, 2018 Acute myeloid leukemia (AML) with the inv(16)/t(16;16) karyotype is associated with a favourable prognosis, showing longer periods of complete remission and high overall survival rates.
P.J. Poddighe +12 more
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Detection of del(16q) using the CBFB-MYH11 translocation dual fusion probe
Hematology/Oncology and Stem Cell Therapy, 2021 Del(16q) is an uncommon cytogenetic abnormality that can occur in different types of myeloid neoplasms. A small number of cases with del(16q) have been reported.
Doaa F. Temerik +2 more
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