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SEPSIS-INDUCED MYOCARDIAL DYSFUNCTION
Shock, 2006Despite the fact that septic patients exhibit altered cardiac function, it is not considered a major pathology during sepsis. Thus, the molecular mechanisms underlying sepsis-induced myocardial dysfunction have not been studied extensively. In a polymicrobial septic rat model, +dP/dt and -dP/dt on day 1 were not altered but found depressed later, i.e.,
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Dysfunction of myocardial sarcoplasmic reticulum in rats with myocardial calcification
Life Sciences, 2005We investigated the relationship between cardiac dysfunction and Ca2+ transport in the myocardial sarcoplasmic reticulum (SR) during the pathogenesis of cardiovascular calcification in rats. The possible mechanism of SR dysfunction was explored by detecting the alteration of the nitric oxide/nitric oxide synthase (NO/NOS) pathway in the SR.
Geng, Bin +5 more
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Myocardial Dysfunction Postresuscitation
2005Real strides have been made in the last decade in the treatment of sudden cardiac death. Survival rates from out-of-hospital cardiac arrest (CA) have been reported as low as 1 and 2% in large cities (1,2). Communities with rapid emergency response teams have reported better results with survival rates from 15 to 30% (3).
Alejandro Vasquez, Karl B. Kern
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Development of myocardial dysfunction in endotoxin shock
American Journal of Physiology-Heart and Circulatory Physiology, 1985Isolated heart muscle preparations were used to investigate the onset and development of myocardial inotropic dysfunction during endotoxin shock in guinea pigs. Left atrial muscles were removed from separate groups of animals at increasing time intervals after administration of either 4 mg/kg purified Escherichia coli endotoxin (shock groups) or an ...
J L, Parker, H R, Adams
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Postresuscitation Myocardial Dysfunction
1999The ultimate goal of cardiopulmonary resuscitation (CPR) for the nearly 500,000 victims of sudden death in the United States is to return the victims to long-term and functional survival. Yet of the approximately 39% of victims who are initially resuscitated successfully, as few as 3% represent hospital survivors [1, 2]. This large fall off in survival
H. Yamaguchi, M. H. Weil
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MYOCARDIAL DYSFUNCTION IN POLYTRAUMA
BULLETIN OF SURGERY IN KAZAKHSTANTrauma remains one of the leading causes of mortality worldwide, particularly among the young population. A significant number of people die within the first 48 hours due to acute cardiovascular pathology. Cardiac injury is a significant predictor of adverse outcomes following multiple trauma, associated with poor prognosis and prolonged ...
M.S. Bekbossynova +8 more
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Myocardial dysfunction in sepsis.
Progress in clinical and biological research, 1987A synthesis of the postulated sequence of events for development of the inappropriate response of the myocardium to a demand for increased cardiac index is schematically represented in Fig. 10. In sepsis, bacteremia and/or the release of endotoxin activate the macrophages which release a spectrum of mediators. Some of these mediators (and possibly also
J J, Spitzer +3 more
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Myocardial Dysfunction in Sepsis
1990Sepsis and septic shock remain a major cause of mortality among critically ill patients. Endeavors to discern the underlying pathophysiology have included investigation of the physiologic abnormalities with an eye towards optimal support of the circulation in general and enhancement of oxygen uptake in particular.
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Takayasu's arteritis and myocardial dysfunction
American Heart Journal, 1987C L, Schamroth +3 more
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Myocardial dysfunction: hibernation and remodelling
The Lancet, 2003Zsolt, Köszegi, Emília, Balogh
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