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Thiouracil-induced myocardial fibrosis
Pathology - Research and Practice, 1978Rabbits were fed with thiouracil for 8 months. Subsequently their hearts were examined electron microscopically as well as biochemically for collagen and hexosamine content. Chronic treatment with thiouracil induced an increase in interstitial connective tissue collagen and hexosamine without visible necrosis.
P P, Lunkenheimer +5 more
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Noncoding RNAs and myocardial fibrosis
Nature Reviews Cardiology, 2014Cardiac stress leads to remodelling of cardiac tissue, which often progresses to heart failure and death. Part of the remodelling process is the formation of fibrotic tissue, which is caused by exaggerated activity of cardiac fibroblasts leading to excessive extracellular matrix production within the myocardium.
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Myocardial fibrosis — a rare complication in patients with cystic fibrosis
European Journal of Pediatrics, 1993We report a 10-month-old male infant who was admitted to our hospital with a history of failure to thrive and bulky stools. On examination, he was dystrophic and had a protruding abdomen, but he was well oxygenated and his lungs were clear on auscultation.
W, Wiebicke, A, Artlich, I, Gerling
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Regulation of Myocardial Fibrosis by MicroRNAs
Journal of Cardiovascular Pharmacology, 2010Interstitial and perivascular fibrosis is a hallmark of adverse cardiac remodeling in response to stress such as hypertension, valve disease, or myocardial infarction. The cross talk between fibroblasts and cardiomyocytes seems to be a major determinant of the hypertrophic response, and fibroblasts may prove to be essential regulators of cardiac ...
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Patterns of myocardial fibrosis.
Journal of molecular and cellular cardiology, 1990The interstitium of the myocardium is composed of predominantly type I collagen; type III collagen is present to a lesser extent. The fibrillar collagens serve as tethers between muscle cells, muscle fibers, and blood vessels while also providing a scaffolding that supports the muscular and vascular compartments.
K T, Weber +4 more
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Matricellular Protein Cilp1 Promotes Myocardial Fibrosis in Response to Myocardial Infarction
Circulation Research, 2021John McAnally, Yonghao Yu, Yongnan Li
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Multimodality Imaging Assessment of Myocardial Fibrosis
JACC: Cardiovascular Imaging, 2021Raymond Kwong, Sumit Gupta
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