Results 161 to 170 of about 3,950,906 (300)

Sema4A neutralization reduces fibrosis and inflammation in a mouse model of systemic sclerosis and a 3D model of immunity‐driven fibrosis

Arthritis &Rheumatology, Accepted Article.
Objective We previously showed that Semaphorin4A (Sema4A) is elevated in patients with systemic sclerosis (SSc) and promotes inflammation and fibrosis in vitro. Here, we examined the effect of Sema4A neutralization in vivo and in 3D fibrosis models. Methods Sema4A plasma levels were measured by ELISA in healthy controls (n=31) and patients with SSc (n=
Jaime Marty, Sara Martinez‐Ramos, Carlos Rafael‐Vidal, Beatriz Malvar‐Fernández, Tiago Carvalheiro, Ralph G. Tieland, Ines Ramos, Wiola Marut, Ana Pinheiro‐Lopes, Ana Argibay, Brenda Maure, Caritina Vázquez‐Triñanes, Nair Pérez Gómez, David Fernández‐Fernández, Sandra Vila, Coral Mouriño, Rogier M Thurlings, Arjan van Caam, Alberto Rivera, José María Pego‐Reigosa, Timothy R. Radstake, Samuel Garcia   +21 more
wiley   +1 more source

Comparison of the prognostic value of impaired stress myocardial blood flow, myocardial flow reserve, and myocardial flow capacity on low-dose Rubidium-82 SiPM PET/CT. [PDF]

J Nucl Cardiol, 2023
Dietz M, Kamani CH, Allenbach G, Rubimbura V, Fournier S, Dunet V, Treglia G, Nicod Lalonde M, Schaefer N, Eeckhout E, Muller O, Prior JO.   +11 more
europepmc   +1 more source

Blood pressure effects of SGLT2 inhibitors and GLP‐1 receptor agonists: Mechanisms, trial evidence and Real‐world data

British Journal of Clinical Pharmacology, EarlyView.
SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić, Yusuf Ziya Sener, Marijana Vučković, Joseph Edgar Blais, Almir Fajkić, Emina Sher, Mislav Radić, Josipa Radić   +7 more
wiley   +1 more source

Incremental Prognostic Value of Subendocardial Myocardial Flow Reserve in Patients With Normal Perfusion. [PDF]

Circulation
Lopez DM, Brown JM, Divakaran S, Huck DM, Weber BN, Hainer J, Carre S, Lemley M, Ramirez G, Shanbhag A, Kavanagh P, Liang JX, Blankstein R, Dorbala S, Dey D, Knight S, Le VT, Mason S, Wopperer S, Chareonthaitawee P, Rosamond TL, Kwiecinski J, Miller RJH, Slipczuk L, Travin MI, Alexanderson E, Carvajal-Juarez I, Packard RRS, Al-Mallah MH, Einstein AJ, Feher A, Acampa W, Sanghani R, Buechel RR, deKemp RA, Berman DS, Slomka PJ, Di Carli MF.   +37 more
europepmc   +1 more source

[the Coronary Flow Reserve During Reperfusion In Myocardial Infarction].

, 2015
The study of coronary flow reserve on the reperfused myocardium damaged by 90 minutes of severe ischemia. Nine mongrel dogs of either sex, weighing 12 to 17 kg were studied.
Jorge, P A, Curti, H V, Metze, K
core  

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source

Coronary microvascular dysfunction in systemic sclerosis: insights from PET-derived myocardial flow reserve. [PDF]

Rheumatology (Oxford)
Williams K, Emokpae M, Koyi B, Csecs I, Gunes I, Frohlich B, Sinusas AJ, Hinchcliff M, Feher A.   +8 more
europepmc   +1 more source

Functional Assessment of Coronary Artery Disease by Myocardial Flow Reserve Versus Pressure-wire Based Assessment: A Systematic Review. [PDF]

Ann Nucl Cardiol, 2021
Manabe O, Aikawa T, Naya M, Miura S, Oyama-Manabe N.   +4 more
europepmc   +1 more source

Comparing outcomes using low‐dose apixaban and anti‐Xa monitoring and vitamin K antagonists in patients with renal replacement therapy

British Journal of Clinical Pharmacology, EarlyView.
Background Guidelines recommend oral anticoagulation for stroke prevention in atrial fibrillation and secondary prevention of venous thromboembolism. Outside the United States, apixaban is unlicensed for use in patients with end‐stage renal disease (ESRD) receiving renal replacement therapy (RRT).
John K. Bartoli‐Abdou, Alexander T. Cohen, Lucy Vernon, Victoria Collings, Ubonphan Chaichana, Natasha Moore, Hamda Jibril, Li Wei, Nicola Kumar, Karen A. Breen, Andrew J. Doyle   +10 more
wiley   +1 more source

Analysis of Y-graft blood flow and flow reserve in conditions of increased myocardial oxygen consumption

, 2004
Background: It is not well established whether early following surgery the blood flow of arterial composite Y-grafts may efficiently meet the flow demand of the coronary system.
A. Spina, A. Innorta, C. Antona, M. Lemma, G. Gelpi, A. Mangini   +5 more
core   +1 more source