Results 131 to 140 of about 1,289,832 (353)

Artesunate Inhibits Neointimal Hyperplasia by Promoting IRF4 Associated Macrophage Polarization

Advanced Science, EarlyView.
This study shows that macrophage interferon regulatory factor 4 (IRF4) improved arterial injury‐induced neointimal hyperplasia by promoting of M2 polarization via up‐regulating krüppel‐like factor 4 (KLF4) in rodent and nonhuman primate models. Notably, artesunate is identified as a potent inducer of IRF4 in macrophages, and proposed as a promising ...
Jinlin Miao, Yule Yong, Zhaohui Zheng, Kui Zhang, Wei Li, Jiayi Liu, Siyi Zhou, Juan‐juan Qin, Haoyang Sun, Yatao Wang, Xianghui Fu, Xing Luo, Siyu Chen, Zhi‐Gang She, Jingjing Cai, Ping Zhu   +15 more
wiley   +1 more source

Building Computational Models to Predict One-Year Mortality in ICU Patients with Acute Myocardial Infarction and Post Myocardial Infarction Syndrome [PDF]

arXiv, 2018
Heart disease remains the leading cause of death in the United States. Compared with risk assessment guidelines that require manual calculation of scores, machine learning-based prediction for disease outcomes such as mortality can be utilized to save time and improve prediction accuracy.
arxiv  

The association of endothelial injury and systemic inflammation with perioperative myocardial infarction [PDF]

, 2019
Background Major surgery predisposes to endothelial glycocalyx injury. Endothelial glycocalyx injury associates with cardiac morbidity, including spontaneous myocardial infarction.
Lakkisto, Paivi, Nisula, Sara, Ollila, Aino, Pettila, Ville, Tikkanen, Ilkka, Venermo, Maarit, Vikatmaa, Leena, Vikatmaa, Pirkka, Virolainen, Juha   +8 more
core   +1 more source

Osteosarcoma Cell‐Derived Migrasomes Promote Macrophage M2 Polarization to Aggravate Osteosarcoma Proliferation and Metastasis

Advanced Science, EarlyView.
Migrasomes are newly discovered organelles in migrating cells. This study finds that osteosarcoma cell‐derived migrasomes promote the tumor‐promoting phenotype of macrophages and further aggravate osteosarcoma malignant progression via milk fat globule‐EGF factor 8.
Wanshun Liu, Lei Li, Xiaoming Bai, Mengxue Zhang, Wei Lv, Yongbin Ma, Yuzhi Sun, Hongjing Zhang, Qing Jiang, Qingqiang Yao, Zhi‐Yuan Zhang   +10 more
wiley   +1 more source

Biallelic GTF2IRD1 variants in brothers with profound neurodevelopmental disorder: A possible novel disorder involving a critical gene for Williams syndrome

American Journal of Medical Genetics Part A, Volume 191, Issue 2, Page 332-337, February 2023., 2023
Abstract GTF2IRD1, a gene on chromosome 7 which encodes a transcription factor, is of significant clinical interest due to its heterozygous loss as part of the classical deletion associated with Williams–Beuren syndrome (WBS). However, biallelic variants in GTF2IRD1 alone as part of an autosomal recessive disease have not been previously reported. Here,
Christopher Thomas Cummings, Lois Janelle Starr   +1 more
wiley   +1 more source

Enhancing Prediction Models for One-Year Mortality in Patients with Acute Myocardial Infarction and Post Myocardial Infarction Syndrome [PDF]

arXiv, 2019
Predicting the risk of mortality for patients with acute myocardial infarction (AMI) using electronic health records (EHRs) data can help identify risky patients who might need more tailored care. In our previous work, we built computational models to predict one-year mortality of patients admitted to an intensive care unit (ICU) with AMI or post ...
arxiv  

Assessment and classification of patients with myocardial injury and infarction in clinical practice [PDF]

, 2016
Myocardial injury is common in patients without acute coronary syndrome, and international guidelines recommend patients with myocardial infarction are classified by aetiology.
Alpert, Alpert, Apple, Apple, Baron, Body, Bonaca, Bonaca, Chapman, Chin, Collinson, Collinson, El-Haddad, Hessel, Javed, Makam, Melanson, Melberg, Mills, Morrow, Neumann, Roffi, Rubini-Gimenez, Saaby, Sabatine, Sandoval, Sandoval, Sarkisian, Shah, Shah, Shah, Shah, Shah, Smith, Smith, Stein, Szymański, Thygesen, Thygesen, Wang, White, White   +41 more
core   +1 more source

PCI Strategies in Patients with Acute Myocardial Infarction and Cardiogenic Shock

New England Journal of Medicine, 2017
Background In patients who have acute myocardial infarction with cardiogenic shock, early revascularization of the culprit artery by means of percutaneous coronary intervention (PCI) improves outcomes.
H. Thiele, I. Akin, M. Sandri, G. Fuernau, S. de Waha, R. Meyer‐Saraei, P. Nordbeck, T. Geisler, U. Landmesser, C. Skurk, A. Fach, H. Lapp, J. Piek, M. Noc, Tomaz Goslar, S. Felix, L. Maier, J. Stȩpińska, K. Oldroyd, P. Serpytis, G. Montalescot, O. Barthelemy, K. Huber, S. Windecker, S. Savonitto, P. Torremante, C. Vrints, S. Schneider, S. Desch, U. Zeymer   +29 more
semanticscholar   +1 more source

3‐D Sustained‐Release Culture Carrier Alleviates Rat Intervertebral Disc Degeneration by Targeting STING in Transplanted Skeletal Stem Cells

Advanced Science, EarlyView.
Schematic representation of mechanisms by which the 3‐D sustained‐release culture carrier prevents accumulation of ROS by continuously releasing C‐176@PDA‐NPs and inhibiting the cGAS‐STING activated by sudden hypoxia, thereby preventing ferroptosis and promoting differentiation in SSCs and ultimately attenuating IVDD progression.
Liwen Luo, Shiyu Zhang, Junfeng Gong, Ji Zhang, Peng Xie, Jun Yin, MengJie Zhang, Cong Zhang, Hong Chen, Yao Liu, Bing Ni, Changqing Li, Zhiqiang Tian   +12 more
wiley   +1 more source

To unwind the biological knots: The DNA/RNA G‐quadruplex resolvase RHAU (DHX36) in development and disease

Animal Models and Experimental Medicine, Volume 5, Issue 6, Page 542-549, December 2022., 2022
Schematic diagram showing RHAU can bind and unwind the G4 “knots” to modulate embryonic development and post‐natal organ function. Deficiency of RHAU gives rise to embryonic lethality, impaired organogenesis and organ dysfunction. RHAU modulates Nkx2‐5 mRNA and Yap1 mRNA at the post‐transcriptional level and facilitates the transcription of c‐Kit and ...
Chensi Yang, Jie Yao, Huijuan Yi, Xinyi Huang, Wukui Zhao, Zhongzhou Yang   +5 more
wiley   +1 more source