Results 11 to 20 of about 209,868 (243)

SR-A3 Promotes USP18-Mediated deISGylation of STING to Protect Against Myocardial Ischemia-Reperfusion Injury. [PDF]

Adv Sci (Weinh)
MI/RI is a major clinical challenge with high morbidity and mortality. This study demonstrates that SR‐A3 expression is downregulated in MI/RI, and its deletion exacerbates damage via the USP18/ISG15/STING axis, revealing SR‐A3 as a potential therapeutic target.
Han Y, Miao G, Zhao Y, Du Z, Lu K, Xiao C, Xian A, Duanmu J, Zhou Z, Chen J, Zhang L, Zhai C, Xu Y, Li Z, Shen X, Shi S, Chen J, Mei S, Fang Y, Zheng L, Zhang L, Wang Y, Huang W, Dong E, Xian X.   +24 more
europepmc   +2 more sources

Silent Myocardial Ischemia [PDF]

Circulation, 2003
Silent myocardial ischemia is defined as objective documentation of myocardial ischemia in the absence of angina or anginal equivalents. Since its original description in the 1970s, it has undergone intensive investigation, and its clinical significance is now well established.
Peter F, Cohn, Kim M, Fox, Caroline, Daly   +2 more
openaire   +2 more sources

Microenvironment-Responsive Nanomedicine Enables Vertical Modulation of Mitochondrial Pathological Networks in Myocardial Ischemia-Reperfusion Injury. [PDF]

Adv Sci (Weinh)
A mitochondria‐targeted, microenvironment‐responsive nanoplatform enables pH/ROS‐triggered co‐delivery of berberine and isoliensinine to orchestrate ROS scavenging, inflammation suppression, and apoptosis inhibition. This vertical modulation of mitochondrial pathological networks preserves mitochondrial function and effectively mitigates myocardial ...
Wang J, Zhou J, Yuan W, Zhao T, Huang Y, Xia Y, Lin Y, Li F, Huang Q, Liu C, Ai K, Qin Q.   +11 more
europepmc   +2 more sources

A novel swine model for evaluation of dyslipidemia and atherosclerosis induced by human CETP overexpression

Lipids in Health and Disease, 2017
Background The mechanism of cholesteryl ester transfer protein (CETP) in lipid metabolism is still unclear. Furthermore, the relationship of CETP and atherosclerosis (AS) has been controversial. As pigs are a good model for both lipid and AS research, we
Tao Chen, Meng Sun, Jia-Qiang Wang, Jin-Jin Cui, Zhong-Hua Liu, Bo Yu   +5 more
doaj   +1 more source

Hypertension and Myocardial Ischemia

Medical Clinics of North America, 2009
Detailed studies over the past 30 years have built up an impressive evidence base for the presence of myocardial ischemia in patients who have hypertension. This relationship ranges from the obvious association with obstructive coronary artery disease to mechanisms related to hemodynamic, microcirculatory, and neuroendocrine abnormalities. All of these
Murphy, BP, Stanton, T, Dunn, FG
openaire   +5 more sources

NOX1 promotes myocardial fibrosis and cardiac dysfunction via activating the TLR2/NF-κB pathway in diabetic cardiomyopathy

Frontiers in Pharmacology, 2022
Diabetic cardiomyopathy (DCM) is a prevalent complication in patients with diabetes, resulting in high morbidity and mortality. However, the molecular mechanisms of diabetic cardiomyopathy have yet to be fully elucidated. In this study, we investigated a
Dandan Zhang, Dandan Zhang, Yilan Li, Yilan Li, Weijie Wang, Weijie Wang, Xueyan Lang, Xueyan Lang, Yanxiu Zhang, Yanxiu Zhang, Qianqian Zhao, Qianqian Zhao, Jingru Yan, Jingru Yan, Yao Zhang, Yao Zhang   +15 more
doaj   +1 more source

Omentin-1 effects on mesenchymal stem cells: proliferation, apoptosis, and angiogenesis in vitro

Stem Cell Research & Therapy, 2017
Background Mesenchymal stem cells (MSCs) are emerging as an extremely promising therapeutic agent for tissue repair. However, limitations exist such as the low numbers of MSCs obtained from donors, and the poor survival and function of donor cells ...
Li Yin, Dan Huang, Xinxin Liu, Yongshun Wang, Jingjin Liu, Fang Liu, Bo Yu   +6 more
doaj   +1 more source

Silent Myocardial Ischemia [PDF]

Mayo Clinic Proceedings, 1990
ST-segment depression in the absence of symptoms is now a well-defined abnormality in patients with coronary artery disease. ST-segment depression without the occurrence of angina is a marker for myocardial perfusion defects and ischemia. During 24-hour recordings, most episodes of ischemia in patients with coronary artery disease are silent and occur ...
S C, Hammill, B K, Khandheria
openaire   +4 more sources

Focal Geometry and Characteristics of Erosion-Prone Coronary Plaques in vivo Angiography and Optical Coherence Tomography Study

Frontiers in Cardiovascular Medicine, 2021
Objective: This study compared focal geometry and characteristics of culprit plaque erosion (PE) vs. non-culprit plaques in ST-segment elevated myocardial infarction (STEMI) patients in whom optical coherence tomography (OCT) identified PE as the cause ...
Muhua Cao, Muhua Cao, Tianyu Wu, Tianyu Wu, Jiawei Zhao, Jiawei Zhao, Zhuo Du, Zhuo Du, Zhuozhong Wang, Zhuozhong Wang, Lulu Li, Lulu Li, Guo Wei, Guo Wei, Jinwei Tian, Jinwei Tian, Haibo Jia, Haibo Jia, Gary S. Mintz, Bo Yu, Bo Yu   +20 more
doaj   +1 more source

Achieved low-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio predicts the pathophysiological evolution of lipid-rich plaques in acute coronary syndromes: an optical coherence tomography study

Frontiers in Cardiovascular Medicine, 2023
BackgroundAs a novel lipoprotein ratio, baseline low-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (LHR) is closely related to the clinical outcomes of acute coronary syndromes (ACS) after percutaneous coronary ...
Luping He, Luping He, Boling Yi, Boling Yi, Dirui Zhang, Dirui Zhang, Sining Hu, Sining Hu, Chen Zhao, Chen Zhao, Rui Sun, Rui Sun, Jianlin Ma, Jianlin Ma, Jingbo Hou, Jingbo Hou, Haibo Jia, Haibo Jia, Lijia Ma, Lijia Ma, Bo Yu, Bo Yu   +21 more
doaj   +1 more source