Results 41 to 50 of about 176,278 (292)

A randomized, placebo-controlled trial of late Na current inhibition (ranolazine) in coronary microvascular dysfunction (CMD): impact on angina and myocardial perfusion reserve. [PDF]

, 2015
AimsThe mechanistic basis of the symptoms and signs of myocardial ischaemia in patients without obstructive coronary artery disease (CAD) and evidence of coronary microvascular dysfunction (CMD) is unclear.
Anderson, R David, Bairey Merz, C Noel, Berman, Daniel S, Brown, Garrett H, Cook-Wiens, Galen, Handberg, Eileen M, Mehta, Puja K, Minissian, Margo B, Pepine, Carl J, Petersen, John W, Rogatko, André, Shaw, Leslee J, Shufelt, Chrisandra L, Shuster, Jonathan J, Thomson, Louise EJ, Wei, Janet   +15 more
core   +1 more source

Inhibition of microRNA-183 expression resists human umbilical vascular endothelial cells injury by upregulating expression of IRS1

Drug Delivery, 2019
Our study aims to investigate the effect of microRNA-183 (miR-183) on human umbilical vascular endothelial cells (HUVECs) injury by targeting IRS1. HUVECs injury was induced by oxidized low-density lipoprotein (ox-LDL).
Yingying Zhang, Yefei Zhan, Dandan Liu, Bo Yu   +3 more
doaj   +1 more source

The heartbreak of depression: 'Psycho-cardiac' coupling in myocardial infarction [PDF]

, 2017
Ample evidence identifies strong links between major depressive disorder (MDD) and both risk of ischemic or coronary heart disease (CHD) and resultant morbidity and mortality. The molecular mechanistic bases of these linkages are poorly defined. Systemic
Budiono, Boris P, Headrick, John P., Neumann, David L., Peart, Jason N., Shum, David H K, Stapelberg, Nicolas J C   +5 more
core   +1 more source

Establishment of a Novel Mouse Model for Atherosclerotic Vulnerable Plaque

Frontiers in Cardiovascular Medicine, 2021
Background and Aims: Acute coronary syndrome (ACS) is a group of clinical syndromes characterized by rupture or erosion of atherosclerotic unstable plaques.
Xueyu Wang, Xueyu Wang, Yahong Fu, Yahong Fu, Zulong Xie, Muhua Cao, Muhua Cao, Wenbo Qu, Wenbo Qu, Xiangwen Xi, Xiangwen Xi, Shan Zhong, Shan Zhong, Minghui Piao, Minghui Piao, Xiang Peng, Xiang Peng, Ying Jia, Ying Jia, Lingbo Meng, Jinwei Tian   +20 more
doaj   +1 more source

Myocardial ischemia and infarction

Journal of the American College of Cardiology, 2004
Atherosclerotic heart disease is the leading cause of death in developed nations. Manifestations include myocardial ischemia or infarction. In addition, some patients develop cardiovascular insufficiency, with the additional risk of systemic ischemia.
openaire   +3 more sources

Mitochondrial Membrane Permeability Inhibitors in Acute Myocardial Infarction Still Awaiting Translation [PDF]

, 2016
Despite therapeutic advances, acute myocardial infarction (AMI) remains a leading cause of morbidity and mortality worldwide. One potential limitation of the current treatment paradigm is the lack of effective therapies to optimize reperfusion after ...
Abbate, Antonio, Thurber, Clinton J., Toldo, Stefano, Trankle, Cory   +3 more
core   +2 more sources

Benefits of Simultaneous Pacing Left Anterior/Posterior Fascicular Areas Combined with Atrioventricular Node Ablation in a Persistent Atrial Fibrillation Patient with Heart Failure: A Case Report

Clinical Medicine Insights: Cardiology
A 50-year-old male had intermittent episodes of dyspnea for 7 days with persistent atrial fibrillation (AF) for 2 years. New York Heart Association (NYHA) functional class is IV status.
Bingchen Guo, Yanzong Liu, Jian Xu, Huimin Xian, Xiaohan Lin, Guoqing Du, Bo Yu, Shufeng Li, Wenjuan Du   +8 more
doaj   +1 more source

Polydatin ameliorates ovalbumin‐induced asthma in a rat model through NCOA4‐mediated ferroautophagy and ferroptosis pathway

FEBS Open Bio, EarlyView.
In this research, a rat model of asthma was created using OVA, and polydatin served as an intervention. By inhibiting ferroautophagy mediated by NCOA4 and averting ferroptosis, polydatin has been demonstrated to reduce asthma. This work presents new ideas for investigating the mechanism of polydatin's ability to alleviate asthma, in addition to ...
Wei Li, Yuwei Tang, Wenkang Liu, Fang Fang, Jiepeng Wang, Chaoyi Fang   +5 more
wiley   +1 more source

Overestimated Myocardial Ischemia

Annals of Noninvasive Electrocardiology
ABSTRACTWe introduced a case of a 69‐year‐old female patient with mitral valve prolapse with severe regurgitation who was transferred from the ICU to a regular ward after undergoing mitral valve replacement surgery. Routine ECG examination showed that the precordial leads were affected by the apical pulsation, leading to pseudo‐ST segment depression ...
Hang Lv, Ming Liu
openaire   +3 more sources

Why we might not need to stress about ruling out inducible myocardial ischemia [PDF]

, 2020
Editorial on the high-sensitivity cardiac troponin (hs-cTn ...
Bell, Katy J.L., Doust, Jenny, Semsarian, Christopher   +2 more
core   +1 more source