Results 51 to 60 of about 315,058 (309)

Cytokine Engineering Approaches for Regenerative Medicine

Advanced Therapeutics, EarlyView.
Engineered cytokines represent a powerful strategy to promote tissue repair and regeneration by precisely modulating immune responses. This review highlights recent advances in cytokine engineering, including strategies to enhance half‐life, improve tissue and cell targeting, and control receptor signaling.
Shiyi Li, Wenhao You, Mikaël M. Martino
wiley   +1 more source

Aging-associated Alteration in the Cardiac MIF-AMPK Cascade in Response to Ischemic Stress [PDF]

, 2008
An important role for a macrophage migration inhibitory factor (MIF)-AMP-activated protein kinase (AMPK) signaling pathway in ameliorating myocardial damage following ischemia/reperfusion has been described. An aging-associated reduction in AMPK activity
Erin Lane, Heng Ma, Ji Li, Jingying Wang, Jun Ren, Lin Leng, Richard Bucala, Wenkui Wang   +7 more
core   +1 more source

Involvement of leukotriene pathway in the pathogenesis of ischemia-reperfusion injury and septic and non-septic shock. [PDF]

, 2009
The 5-lipoxygenase (5-LO) pathway is responsible for the production of leukotrienes (LTs), inflammatory lipid mediators which play a role in innate immunity. More recently, a pivotal role of LTs in ischemia-reperfusion and shock injury has been suggested.
CUZZOCREA S, ROSSI, ANTONIETTA, SAUTEBIN, LIDIA   +2 more
core   +1 more source

Engineered RGD‐Treg‐Exos Targeted Delivery of miR‐218‐5p to Activate Mitophagy and Attenuate Podocyte Injury in Diabetic Kidney Disease

Advanced Science, EarlyView.
Tregs‐Exos deliver miR‐218‐5p to increase mitophagy in podocytes by inhibiting the TNC/TLR4/SRC/FUNDC1 pathway. RGD‐Treg‐Exos, engineered to express RGD peptides on the membrane surface, bind to integrins on the surface of podocytes and effectively target podocytes for the delivery of miR‐218‐5p, which increases mitophagy and reduces apoptosis in ...
Zhaochen Guo, Shaohui Gao, Ziyue Wang, Zige Chen, Jinglei Chen, Aiping Duan, Feng Xu, Qinger Wang, Weisong Qin, Caihong Zeng, Zhihong Liu, Hao Bao   +11 more
wiley   +1 more source

Remote preconditioning by aortic constriction: affords cardioprotection as classical or other remote ischemic preconditioning? Role of iNOS [PDF]

, 2011
Dose remote preconditioning by aortic constriction (RPAC) affords cardioprotection similar to classical or other remote ischemic preconditioning stimulus?
Akash Sharma, Arshee Munajjam, Ashish Sharma, Ashish Tiwari, Ashok Sharma, B.P. Srinivasan, Bhawna Vaishnav, Divya Sharma, Kunal Kishore, Richa Sharma, Rita Kumari, Shyam Agarwal   +11 more
core   +1 more source

Inhibition of Autophagy Signaling via 3-methyladenine Rescued Nicotine-Mediated Cardiac Pathological Effects and Heart Dysfunctions. [PDF]

, 2020
Rationale: Cigarette smoking is a well-established risk factor for myocardial infarction and sudden cardiac death. The deleterious effects are mainly due to nicotine, but the mechanisms involved and theranostics remain unclear.
Fu, Yingjie, Huang, Lei, Li, Yong, Liu, Bailin, Shao, Xuesi M, Xiao, Daliao, Zhang, Lubo, Zhang, Peng   +7 more
core  

Cardiac Specific Overexpression of Mitochondrial Omi/HtrA2 Induces Myocardial Apoptosis and Cardiac Dysfunction. [PDF]

, 2016
Myocardial apoptosis is a significant problem underlying ischemic heart disease. We previously reported significantly elevated expression of cytoplasmic Omi/HtrA2, triggers cardiomyocytes apoptosis.
Jiao, Kun, Lau, Wayne Bond, Liu, Huirong, Liu, Xin, Ma, Lu, Ma, Xinliang, Shang, Jianyu, Wang, Ke, Wang, Wen, Wang, Xiaoliang, Yuan, Yuexing, Zuo, Lin   +11 more
core   +2 more sources

USP10 Inhibits Ferroptosis via Deubiquinating POLR2A in Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
This study identifies USP10 as a novel deubiquitinase that antagonizes ferroptosis in head and neck squamous cell carcinoma (HNSCC). Mechanistically, USP10 directly stabilizes POLR2A protein through post‐translational deubiquitination, enabling POLR2A‐mediated transcriptional activation of SLC7A11, a key ferroptosis inhibitor.
Diekuo Zhang, Xueying Wang, Shanhong Lu, Yan Gao, Gangcai Zhu, Guo Li, Zongnan Yu, Junwei Hou, Helei Yan, Wenhui Yuan, Xin Zhang, Mien‐Chie Hung, Zhifeng Liu, Yong Liu   +13 more
wiley   +1 more source

Cardiac-derived CTRP9 protects against myocardial ischemia/reperfusion injury via calreticulin-dependent inhibition of apoptosis. [PDF]

, 2018
Cardiokines play an essential role in maintaining normal cardiac functions and responding to acute myocardial injury. Studies have demonstrated the heart itself is a significant source of C1q/TNF-related protein 9 (CTRP9). However, the biological role of
Feng, Pan, Gao, Erhe, Lau, Wayne Bond, Ma, Xin-Liang, Qin, Zhigang, Sun, Yang, Tan, Yanzhen, Xu, Xuezeng, Yang, Jian, Yi, Dinghua, Yi, Wei, Yu, Shiqiang, Zhang, Zhengbin, Zhao, Dajun   +13 more
core   +2 more sources

Revealing Cell‐Free Mitochondrial DNA Breakage Patterns as Novel Biomarkers for Sepsis

Advanced Science, EarlyView.
Uncovering distinct plasma cfmtDNA breakage patterns opens new frontiers for early sepsis detection and prognosis. Unique cleavage hotspots in RNR2 and COX2 regions outperform traditional biomarkers, while mechanistic insights suggest bacterial endonuclease involvement.
Haitang Liao, Ruiyan Ma, Shuai Hao, Xuxin Tan, Xue Zeng, Rui Song, Bing Chen, Zhezhe Cao, Wei Shen, Zhenchun Luo, Jianfeng Huang, He Huang, Liangming Liu, Chenyang Duan   +13 more
wiley   +1 more source