Comparative Genomics and Functional Evidence for Convergent Adaptation to Hypoxia in Mammals
This study reveals convergent selection in mammals adapted to hypoxia. Functional assays demonstrate that amino acid mutations reduce oxidative stress, attenuate hypoxia‐induced injury, and modulate the hypoxia‐inducible transcription factor (HIF)‐driven hypoxic response.
Hao Dong +5 more
wiley +1 more source
A novel dynamic cardiac phantom for comparing blood pool and myocardial perfusion tracers: initial evaluation with CZT-ERNA and PET-MPI. [PDF]
Nielsen MØ +7 more
europepmc +1 more source
Current research reports that micro‐nanoplastics may increase the burden of cardiovascular disease with significant human and economic consequences. The detection of plastic particles in biological matrices is challenging and rigorous research is required to investigate the clinical and broader public health implications of microplastics.
Adrian Goldsworthy +4 more
wiley +1 more source
Semaglutide Reverses Ectopic Lipid Accumulation, Impaired Myocardial Perfusion Reserve, and Diastolic Dysfunction in a Mouse Model of Cardiometabolic Heart Disease. [PDF]
Skacel TP +8 more
europepmc +1 more source
Across 11 observational studies comprising 6 471 577 patients, the pooled incidence of ischaemic optic neuropathy after cardiac surgery was approximately 1.5 cases per 10 000 procedures. Coronary artery disease, peripheral vascular disease and anaemia were associated with increased odds of ION, although these findings should be interpreted in the ...
Daud Mutahar +11 more
wiley +1 more source
Anomalous origin of the left coronary artery from the pulmonary artery with coronary artery fistula in an adult presenting with cardiomegaly, abnormal electrocardiogram, myocardial perfusion defect and pulmonary hypertension: a case report. [PDF]
Luo L +5 more
europepmc +1 more source
This retrospective cohort compared umbilical‐portal‐systemic venous shunts in singleton and twin pregnancies. Type III was the most common subtype in singletons, whereas Type II was the most common in twins. Fetal growth restriction was more frequent in twins, but primary structural anomaly rates were similar.
Yun Zhang +8 more
wiley +1 more source
The impact of motion correction on quantitatively measured perfusion indices using cardiac-dedicated dynamic CZT-SPECT myocardial perfusion imaging. [PDF]
Chaudhary AK, Zhao F, Pang Z, Li J.
europepmc +1 more source
Consensus surrounding the management of VA ECMO and left ventricular mechanical unloading for cardiogenic shock (CS) is limited. We thus conducted a national survey of practice patterns in the treatment of CS to characterize such variability, finding large heterogeneity in CS diagnosis, VA ECMO initiation, and LVMU strategies.
Dustin M. Anderson‐Bell +16 more
wiley +1 more source
This study is a comprehensive post‐market analysis of the Xenios console and XLung kit 230 preconfigured ECMO tubing set in post‐cardiotomy applications. The performance of this device was evaluated and demonstrated in all key clinical areas, with an adequate safety profile.
Luca Conci +9 more
wiley +1 more source

