Results 61 to 70 of about 554,014 (305)

Bifidobacterium Pseudolongum‐Derived Inosine Mitigates Polystyrene Nanoplastics‐Induced Hepatic Injury by Inhibiting the Polarization of M1 Macrophages

Advanced Science, EarlyView.
Probiotic B.p colonization elevated gut‐derived inosine level in the liver, while elevated inosine activated A2AR and subsequently blocked NPs‐induced polarization of M1 macrophages by repressing the miR155/SOCS1/NF‐κB pathway. This reduced the release of inflammatory cytokines and thereby, mitigated NPs‐induced hepatic injury.
Kaikai Zhang, Yuchuan Chen, Jiayuan Wan, Jianzheng Yang, Lijian Chen, Qingyuan Li, Anding Zhou, Nian Zhou, Jiuyang Ding, Qi Wang, Jian Sun   +10 more
wiley   +1 more source

Metformin and sulodexide restore cardiac microvascular perfusion capacity in diet-induced obese rats

Cardiovascular Diabetology, 2017
Background Disturbances in coronary microcirculatory function, such as the endothelial glycocalyx, are early hallmarks in the development of obesity and insulin resistance.
Judith van Haare, M. Eline Kooi, Jurgen W. G. E. van Teeffelen, Hans Vink, Jos Slenter, Hanneke Cobelens, Gustav J. Strijkers, Dennis Koehn, Mark J. Post, Marc van Bilsen   +9 more
doaj   +1 more source

Cyclic Mechanical Loading of Cardiomyocytes via Pressure‐Driven Non‐Planar Membrane Deformation in a Bioreactor System

Advanced Science, EarlyView.
In this research article, Mansoor and coworkers present a novel device that applies controlled mechanical stimuli to cardiomyocytes using pressure‐driven membrane deformation. By exposing cells to physiologically and pathologically relevant loading conditions, the platform reproduces distinct structural, functional and molecular responses associated ...
Haris Mansoor, Gabrielle Juul, Jil Patel, Heran Pradhan, Gram Hepner, Jackson Jewell, Mark Bardin, Ryan Slusser, Abigail Glezer, Leda Klouda, Melikhan Tanyeri, Anita Saraf   +11 more
wiley   +1 more source

Comparison of left ventricular myocardial perfusion parameters according to adenosine triphosphate stress computed tomography myocardial perfusion with clinical parameters of patients with nonobstructive coronary artery disease

Российский кардиологический журнал
Aim. To assess the relationship between left ventricular (LV) myocardial perfusion parameters according to adenosine triphosphate (ATP) stress computed tomography myocardial perfusion (CTP) with clinical parameters in patients with non-obstructive ...
O. F. Egorkina, S. A. Gaman, G. N. Soboleva, Yu. A. Karpov, S. K. Ternovoy   +4 more
doaj   +1 more source

Clinical outcomes meta-analysis: measuring subendocardial perfusion and efficacy of transmyocardial laser revascularization with nuclear imaging

Journal of Cardiothoracic Surgery, 2017
Introduction Randomized and nonrandomized clinical trials have tried to assess whether or not TMR patients experience an increase in myocardial perfusion.
Jessika Iwanski, Shannon M. Knapp, Ryan Avery, Isabel Oliva, Raymond K. Wong, Raymond B. Runyan, Zain Khalpey   +6 more
doaj   +1 more source

Quantitative myocardial perfusion during stress using CMR is impaired in healthy Middle Eastern immigrants without CV risk factors

Scientific Reports, 2022
Middle Eastern immigrants constitute a growing proportion of the European population and compared to native Swedes are more insulin resistant, which can contribute to atherosclerosis. Quantitative first pass perfusion (qFPP) using cardiovascular magnetic
Robert Jablonowski, Louise Bennet, Henrik Engblom, Anthony H. Aletras, Hui Xue, Peter Kellman, Marcus Carlsson, Håkan Arheden   +7 more
doaj   +1 more source

Thermochemical Micro‐Explosion for Prompt Thrombolysis via Proximal Injection of Liquid Alkali Metal

Advanced Science, EarlyView.
We report a micro‐explosive thermochemical thrombolysis (METCT) therapy via injectable liquid alkali metal encapsulated in dimethyl silicone (LAM@oil). METCT enables prompt and safe vascular recanalization within 90 s. Critically, the LAM@oil system demonstrates significantly higher thrombolytic efficacy compared to clinically available thrombolytic ...
Xin Liao, Yi Hou, Jie Zhang, Bo Wang, Minghui Guo, Hua Qu, Wei Rao, Jing Liu   +7 more
wiley   +1 more source

Perfusion of the interventricular septum during ventilation with positive end-expiratory pressure (PEEP) [PDF]

, 1991
Objective: To determine whether regional hypoperfusion of the interventricular septum occurs during ventilation with positive end-expiratory pressure. Design: Animal study. Animals: Anesthetized, closed chest dogs (n = 8).
Schosser, Rudolf, Messmer, Konrad, Schwickert, Christiane, Zwißler, Bernhard, Spengler, Peter, Weiss, Michaela, Iber, Volker   +6 more
core   +1 more source

Interpretation of myocardial perfusion SPECT with attenuation correction. Part 2

Вестник рентгенологии и радиологии, 2020
Objective: to investigate the possibilities of a combined single photon emission computed tomography/computed tomography (SPECT/CT) system during myocardial perfusion studies and to examine the features of their interpretation.Subjects and methods.
A. A. Ansheles, V. В. Sergienko
doaj   +1 more source

Myocardial Perfusion in Cardiac Amyloidosis

European Journal of Heart Failure
Abstract Aims Cardiac involvement is the main driver of clinical outcomes in systemic amyloidosis and preliminary studies support the hypothesis that myocardial ischaemia contributes to cellular damage.
Chacko, Liza, Kotecha, Tushar, Ioannou, Adam, Patel, Niket, Martinez‐Naharro, Ana, Razvi, Yousuf, Patel, Rishi, Massa, Paolo, Venneri, Lucia, Brown, James, Porcari, Aldostefano, Knott, Kristopher, Manisty, Charlotte, Knight, Daniel, Lockie, Tim, Rakhit, Roby, Lachmann, Helen, Wechelakar, Ashutosh, Whelan, Carol, Ponticos, Markella, Moon, James, González, Arantxa, Gilbertson, Janet, Riefolo, Mattia, Leone, Ornella, Xue, Hui, Hawkins, Philip, Kellman, Peter, Gillmore, Julian, Fontana, Marianna   +29 more
openaire   +4 more sources