Results 241 to 250 of about 104,281 (302)

Higher sensitivity to ouabain‐induced toxicity in human induced pluripotent stem cell‐derived cardiomyocytes than human adult heart tissue despite similar Na+/K+‐ATPase pump current amplitudes

British Journal of Pharmacology, Volume 183, Issue 11, Page 3093-3110, June 2026.
Abstract Background and Purpose Human induced pluripotent stem cell‐derived cardiomyocytes (hiPSC‐CM) have gained interest as a pharmacological model but their immaturity leads to uncertainty regarding translation. We studied the key player in maintaining ionic homeostasis, the Na+/K+‐ATPase (NKA), in hiPSC‐CM.
Djemail Ismaili, Paavo Virtanen, Junsoo Im, Paul Brunnbauer, Umber Saleem, Muhammed Ikbal Sönmez, Carl Schulz, Margaret Nandudu, Joris Winters, Cristina E. Molina, Johannes Petersen, Monika Stoll, Ulrich Schotten, Arne Hansen, Thomas Eschenhagen, Jussi T. Koivumäki, Torsten Christ   +16 more
wiley   +1 more source

Expanding interpretability through complexity reduction in machine learning-based modelling of cardiovascular disease: A myocardial perfusion imaging PET/CT prognostic study. [PDF]

Eur J Clin Invest
Lehtonen E, Teuho J, Vatandoust M, Knuuti J, Knol RJJ, van der Zant FM, Juárez-Orozco LE, Klén R.   +7 more
europepmc   +1 more source

Cardiovascular Health in Women—Across the Lifespan

Clinical Endocrinology, Volume 104, Issue 6, Page 539-555, June 2026.
ABSTRACT Cardiovascular disease (CVD) remains the leading cause of mortality and morbidity among women worldwide. However, CVD continues to be perceived as a predominantly male issue. CVD in women therefore remains understudied, underrecognized and undertreated.
Jaya Chandrasekhar, Jessica Yao, Simone Gong, Madhuka Wijayarathne, Monique Watts, Swati Mukherjee   +5 more
wiley   +1 more source

Diagnostic Performance of Dynamic Myocardial Perfusion Imaging Using Third-Generation Dual-Source Computed Tomography in Patients with Intermediate Pretest Probability of Coronary Artery Disease. [PDF]

J Cardiovasc Dev Dis
Ko SM, Cha SJ, Kim H, Jeon PH, Jeon SH, Ahn SG, Son JW.   +6 more
europepmc   +1 more source

Estrogen Deprivation During Primate (Papio anubis) Pregnancy: Impact on Systemic Microvascular Flow and Cardiovascular Development and Function After Birth in Offspring

Journal of Medical Primatology, Volume 55, Issue 3, June 2026.
ABSTRACT Background Suppressing estradiol (E2) during baboon pregnancy lowers offspring skeletal muscle capillary density, vital for insulin‐mediated glucose uptake, and induces insulin resistance. We examined whether E2 deprivation also impairs microvascular flow and cardiac function.
Sifa Turan, Jeffery S. Babischkin, Graham W. Aberdeen, Gerald J. Pepe, Eugene D. Albrecht   +4 more
wiley   +1 more source

Clinical Implications of the Washout Phenomenon in Technetium-99m (^99mTc-) Labeled Compounds for Myocardial Perfusion Imaging. [PDF]

Ann Nucl Cardiol
Taniguchi Y.
europepmc   +1 more source

Elevated ASGR1 as a Potential Diagnostic Biomarker for Coronary Artery Disease and Predictor of Adverse Outcomes in Hypertensive Patients

The FASEB Journal, Volume 40, Issue 9, 15 May 2026.
Asialoglycoprotein receptor 1 (ASGR1) is linked to lipid metabolism and CAD, but its role in hypertensive CAD patients is unclear. This single‐center study included 345 hypertensive patients (59 non‐CAD, 286 CAD). Plasma ASGR1 was higher in CAD patients, correlated with multiple markers and HDL‐C, had high diagnostic value (better than traditional ...
Ying Liu, Xinyu Zhou, Peng Hao, Ying Guo, Ning Wang, Kuibao Li, Hongjie Chi, Hong Li, Xiaoyan Yang, Jing Li, Jiuchang Zhong, Lin Zhao, Ying Dong   +12 more
wiley   +1 more source

Assessing the Real-World Safety of Regadenoson for Myocardial Perfusion Imaging: Insights from a Comprehensive Analysis of FAERS Data. [PDF]

J Clin Med
Xu X, Guo Q, Li Y, Zhai C, Mao Y, Zhang Y, Zhang L, Zhang Y.   +7 more
europepmc   +1 more source

Impact of software tools and kinetic model selection on myocardial blood flow and flow reserve quantitation in 13N‐ammonia PET

Journal of Applied Clinical Medical Physics, Volume 27, Issue 5, May 2026.
Abstract Background Quantitative assessment of myocardial perfusion using 13N‐ammonia PET with compartmental modeling enables evaluation of myocardial flow reserve (MFR) and prediction of patient prognosis. However, the reliability of these assessments can depend on the analytical methods used for quantitation.
Naochika Akiya, Kenta Miwa, Akira Ando, Noriaki Miyaji, Tensho Yamao, Kaito Wachi, Masaki Masubuchi, Shu Kimura, Reiji Ito, Arata Komatsu, Takuma Horikawa, Kenji Fukushima, Atsutaka Okizaki, Shiro Miura   +13 more
wiley   +1 more source

Recent Progress in Myocardial Perfusion Imaging Techniques. [PDF]

Nucl Med Mol Imaging
Jo KH, Kang WJ.
europepmc   +1 more source