Results 111 to 120 of about 68,817 (283)

Inducible nitric oxide synthase activation after ischemia/reperfusion contributes to myocardial dysfunction and extent of infarct size in rabbits: evidence for a late phase of nitric oxide-mediated reperfusion injury [PDF]

, 1999
Stephen M. Wildhirt
openalex   +1 more source

Specialized Pro-Resolving Mediators as Emerging Players in Cardioprotection: From Inflammation Resolution to Therapeutic Potential. [PDF]

Acta Physiol (Oxf)
ABSTRACT Aim Timely myocardial reperfusion is essential for restoring blood flow to post‐ischemic tissue, thereby reducing cardiac injury and limiting infarct size. However, this process can paradoxically result in additional, irreversible myocardial damage, known as myocardial ischemia–reperfusion injury (MIRI).
De Bartolo A, Romeo N, Angelone T, Rocca C.   +3 more
europepmc   +2 more sources

Reperfusion injury after acute myocardial infarction [PDF]

, 1995
Ever Grech, Malcolm J. Jackson, David R. Ramsdale   +2 more
openalex   +1 more source

Mitochondrial dysfunction: Related diseases, influencing factors, and detection

Interdisciplinary Medicine, EarlyView.
Mitochondrial dysfunction is implicated in the pathogenesis of numerous diseases, including neurological disorders, cancers, and cardiovascular conditions, through mechanisms such as mitochondrial DNA mutations, dysregulation of mitochondrial network dynamics, and impaired mitophagy.
Zhaojin Li, Shiyu Li, Wanying Chen, Ziyu Zhang, Chun Pan, Peng Lei, Cheng Cheng, Junyou Zhu, Hanxiao Sun, Zhenning Dai   +9 more
wiley   +1 more source

A single cell model of myocardial reperfusion injury: changes in intracellular Na+ and Ca2+ concentrations in guinea pig ventricular myocytes. [PDF]

, 1999
Takuro Nakamura, Hideharu Hayashi, Hiroshi Satoh, Hideki Katoh, Masanori Kaneko, Hajime Terada   +5 more
openalex   +1 more source

Dexmedetomidine Blocks the ERK Pathway by Inhibiting MAP3K8 to Achieve a Protective Effect in Lung Ischemia/Reperfusion Injury

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Lung ischemia/reperfusion injury (LIRI) is a primary contributor to morbidity and mortality following lung transplantation. Dexmedetomidine (DEX) protects the lungs from I/R injury, but the underlying mechanisms remain uncertain. This paper examined the protective effect of DEX in LIRI and elucidated the potential regulation involved. LIRI was
Chun‐Huan Hu, Ru Qian, Yong‐Bo Wang, Lian‐Di Li, Chun‐Xing Miao   +4 more
wiley   +1 more source

Role of the complement components C5 and C3a in a mouse model of myocardial ischemia and reperfusion injury

GMS German Medical Science, 2010
Objective: Ischemic heart disease is the leading cause of death worldwide. The complement system plays a major role in inflammation and tissue injury following myocardial ischemia and reperfusion (MI/R) injury.
Stahl, Gregory L., Busche, Marc N.
doaj  

Mechanisms by which silencing long-stranded noncoding RNA KCNQ1OT1 alleviates myocardial ischemia/reperfusion injury (MI/RI)-induced cardiac injury via miR-377-3p/HMOX1

BMC Cardiovascular Disorders
Background The key complication of myocardial infarction therapy is myocardial ischemia/reperfusion injury (MI/RI), and there is no effective treatment.
Tongcai Tan, Liang Tu, Yanmei Yu, MinJie He, Xingchao Zhou, Lei Yang   +5 more
doaj   +1 more source

Nanozymes in Reactive Oxygen Species‐Dependent Diseases: From Design and Preclinical Studies to Clinical Translation Prospects

Small Structures, EarlyView.
Nanozymes emerge as promising therapeutic agents for reactive oxygen species (ROS)‐dependent diseases, offering advantages over traditional biocatalysts through enhanced stability, tunability, and targeting capabilities. This review explores their mechanisms, design strategies, and clinical progress, emphasizing precision medicine potential.
Lihong Zhou, Jingyu Yan, Chenying Cui, Yurong Xu, Kaifang Zhang, Meijun Du, Zhuowei Zhang, Xiuping Wu, Bing Li   +8 more
wiley   +1 more source

Long non-coding RNA-AK138945 regulates myocardial ischemia-reperfusion injury via the miR-1-GRP94 signaling pathway

Frigid Zone Medicine
Myocardial ischemia-reperfusion injury (MIRI) is one of the leading causes of death from cardiovascular disease in humans, especially in individuals exposed to cold environments.
Wang Yanying, Huang Jian, Sun Han, Liu Jie, Shao Yingchun, Gong Manyu, Yang Xuewen, Liu Dongping, Wang Zhuo, Li Haodong, Zhang Yanwei, Zhang Xiyang, Du Zhiyuan, Leng Xiaoping, Jiao Lei, Zhang Ying   +15 more
doaj   +1 more source