Results 321 to 330 of about 282,175 (385)

CNPY2 Aggravates Renal Tubular Cell Ferroptosis in Diabetic Nephropathy by Regulating PERK/ATF4/CHAC1 Pathway and MAM Integrity

Advanced Science, Volume 12, Issue 25, July 3, 2025.
Canopy FGF signaling regulator 2 (CNPY2) which is contributed to ERS is upregulated in the renal tubules of patients with diabetic nephropathy (DN). Mechanistically, CNPY2 may regulate ferroptosis and MAM integrity in renal tubular epithelial cells through PERK/ATF4/CHAC1 pathway, thereby promoting the progression of DN.
Jingfang Chen, Dongwei Liu, Lei Lei, Ting Liu, Shaokang Pan, Hui Wang, Yong Liu, Yingjin Qiao, Zhangsuo Liu, Qi Feng   +9 more
wiley   +1 more source

The FGF13‐Caveolin‐1 Axis: A Key Player in the Pathogenesis of Doxorubicin‐ and D‐Galactose‐Induced Premature Cardiac Aging

Advanced Science, Volume 12, Issue 25, July 3, 2025.
The FGF13 level is significantly downregulated in premature aging murine hearts subject to D‐galactose and Doxorubicin. FGF13 overexpression and deficiency exacerbated and alleviated Doxorubicin/D‐galactose‐induced myocardial aging characteristics and functional impairment, respectively.
Enzhao Shen, Yuecheng Wu, Weijian Ye, Sihang Li, Junjie Zhu, Meifan Jiang, Zhicheng Hu, Gaoyong Cao, Xiaojing Yi, Fan Li, Zhouhao Tang, Xiaokun Li, Kwang Youl Lee, Litai Jin, Xu Wang, Weitao Cong   +15 more
wiley   +1 more source

INHIBITION OF POLY (ADP-RIBOSE) POLYMERASE-1 ALTERS GENE EXPRESSION DURING MYOCARDIAL ISCHEMIA AND REPERFUSION INJURY: A MICROARRAY ANALYSIS.

, 2003
Basilia Zingarelli, Paul W. Hake, Michael O’Connor, Alvin Denenberg, Shu Kong, Bruce J. Aronow   +5 more
openalex   +1 more source

Exploring mitochondrial health and transplantation strategies in DCD heart transplantation: a systematic review. [PDF]

J Transl Med
Zhang X, Yang Y, Wang H, Yan C, Feng Y, Ma X, Hu M, Li S, Cheng C.   +8 more
europepmc   +1 more source

Myocardial protection from surgical ischemic–reperfusion injury

, 2003

openalex   +1 more source

Antidepressant‐Like Effects of Electroacupuncture by Regulating NLRP3‐mediated Hippocampal Inflammation and Pyroptosis in Rats With Post‐Stroke Depression

Brain and Behavior, Volume 15, Issue 7, July 2025.
Electroacupuncture was found to down‐regulate NLRP3 inflammasome activation to reduce hippocampal inflammation and pyroptosis, suggesting that NLRP3 inflammasome could be a potential target for PSD treatment. ABSTRACT Objective This study aimed to investigate whether the antidepressant‐like effects of electroacupuncture (EA) are associated with the ...
Wa Cai, Xi‐Fang Wei, Larissa Tao, Wei‐Dong Shen   +3 more
wiley   +1 more source

Shexiang Tongxin Dripping Pills regulates SOD/TNF-α/IL-6 pathway to inhibit inflammation and oxidative stress to improve myocardial ischemia-reperfusion injury in mice. [PDF]

Front Cardiovasc Med
Du W, Zhai C, Zhang H, Ren J, Chen X, Sun X, Li C, Wang W, Chen Y.   +8 more
europepmc   +1 more source

Acute Coronary Syndrome Manifesting Dynamic Electrocardiographic Changes

Clinical Case Reports, Volume 13, Issue 7, July 2025.
ABSTRACT We present a patient with acute coronary syndrome manifesting dynamic evolution from an anterior ST‐segment elevation myocardial infarction electrocardiographic pattern to the de Winter electrocardiographic pattern suggestive of severe residual myocardial ischemia owing to a partially recanalized but still subtotally occluded culprit artery ...
Andreas Y. Andreou
wiley   +1 more source

Cardioprotection Through Pharmacological Activation of Sirtuin 5 in a Murine Model of Acute Myocardial Infarction. [PDF]

Drug Des Devel Ther
Castiello C, Efentakis P, Nikolaou PE, Symeonidi L, Chania C, Barla I, Akrani I, Kostomitsopoulos N, Gikas E, Thomaidis NS, Mikros E, Kleinbongard P, Fioravanti R, Zwergel C, Valente S, Mai A, Andreadou I.   +16 more
europepmc   +1 more source

YOD1 regulates oxidative damage of dopamine neurons in Parkinson's disease by deubiquitinating PKM2

Clinical and Translational Medicine, Volume 15, Issue 7, July 2025.
YOD1 binds to PKM2 and reduces its ubiquitination level by removing the K63 ubiquitin chain of PKM2, thereby increasing the tetramer level and reducing the dimer level of PKM2. It then inhibited dimerized PKM2 entry into the nucleus and activated the Nrf2 signaling pathway, thus promoting oxidative stress.
Xia Zhao, Jinfeng Sun, Fan Chen, Hao Tang, Yuqing Zeng, Luyao Li, Qin Yu, Linjie Chen, Muzaffar Hammad, Xiaoxia Xu, Ziyao Meng, Wei Wang, Guang Liang   +12 more
wiley   +1 more source