Results 161 to 170 of about 14,229 (340)

Eplontersen for Hereditary Transthyretin Amyloidosis With Polyneuropathy: An Exploratory Analysis of Treatment Effect in Male and Female Patients

open access: yesMuscle &Nerve, EarlyView.
This exploratory analysis of data from the NEURO‐TTRansform trial evaluated sex‐specific responses in patients with ATTRv‐PN who had received eplontersen in NEURO‐TTRansform versus a historical placebo. Eplontersen can lead to substantial decreases in percentage serum TTR levels, arrest neuropathy impairment, and improve patient quality of life ...
Márcia Waddington Cruz   +11 more
wiley   +1 more source

Prophylactic Dexmedetomidine Reduces Junctional Ectopic Tachycardia and Facilitates Postoperative Recovery in Pediatric Cardiac Surgery: A Systematic Review and Meta‐Analysis of Prospective Trials

open access: yesPediatric Anesthesia, EarlyView.
ABSTRACT Objective To evaluate the efficacy and safety of prophylactic dexmedetomidine in preventing Junctional Ectopic Tachycardia (JET) and its impact on postoperative recovery in pediatric congenital heart surgery, restricting analysis to prospective trials. Methods We systematically searched PubMed, Scopus, and CENTRAL through October 16, 2025, for
Michelle Singh   +5 more
wiley   +1 more source

Staging concept for aging management: Definition, mechanism, and coping strategies

open access: yesVIEW, EarlyView.
We divided the overall aging stage into “pre‐aging”, “aging compensation”, and “aging disability”. For each stage, we delineate the clinical presentations, biological phenomena, theoretical underpinnings, and key management priorities. Abstract Aging, as a gradual and largely irreversible biological process, characterized by declining organismal ...
Zhonghan Wang   +6 more
wiley   +1 more source

Reproductive Challenges of the Ageing Female: A Comprehensive Narrative Review

open access: yesBJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Changes in societal norms over the last few decades have resulted in novel family planning trends, notably delayed childbearing and increased maternal age at the birth of the first child. Despite advances in reproductive medicine, ageing poses significant challenges.
Sofia Bitzika   +6 more
wiley   +1 more source

Post‐mortem CT detection of fatal air embolism after aerosolized fibrin glue for bladder bleeding

open access: yesJournal of Forensic Sciences, EarlyView.
Abstract Radiation‐induced hemorrhagic cystitis (RHC) is a severe complication of pelvic radiotherapy, often used to treat various pelvic malignancies. Despite multiple therapeutic options, including conservative and invasive interventions, the optimal management remains uncertain. We report the case of a 76‐year‐old male with pulmonary emphysema and a
Beatrice Benedetti   +6 more
wiley   +1 more source

Rare but relevant: Ibogaine and cardiovascular complications—prolonged QT interval and ventricular arrhythmias

open access: yesAddiction, EarlyView.
Abstract Revived interest in psychedelic‐assisted therapies has also renewed focus on ibogaine, a psychoactive alkaloid, for its notable anti‐addictive potential. Evidence from observational, open‐label, and limited randomized placebo‐controlled trials indicates that ibogaine and its metabolite noribogaine reduce craving and withdrawal symptoms in ...
Tibor Markus Brunt
wiley   +1 more source

Signaling and cellular mechanisms in cardiac protection by ischemic and pharmacological preconditioning [PDF]

open access: yes, 2018
Ischemic preconditioning (IPC) is a defensive adaptive cellular phenomenon. Brief ischemic stimuli render the heart resistant to subsequent similar stress. Signaling for IPC and pharmacologically induced preconditioning involves several G-protein coupled
Schaub, Marcus, Zaugg, Michael
core  

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