Results 181 to 190 of about 337,957 (243)

A new approach to an old disease: Ageing, arrhythmogenic substrate and the role of risk‐factor modification in atrial fibrillation

Experimental Physiology, EarlyView.
Abstract Atrial fibrillation (AF) prevalence rises sharply with age due to two independent mechanisms. Ageing produces irreversible arrhythmogenic substrate changes through progressive fibrosis, cellular senescence and mitochondrial dysfunction, while modifiable risk factors such as obesity, hypertension, sleep apnoea, diabetes and alcohol use promote ...
Udit Thakur, Jonathan M. Kalman
wiley   +1 more source

Haemodynamic effects of selective venoconstriction with centhaquine in spontaneously breathing patients with mixed hypovolaemic‐vasodilatory shock

Experimental Physiology, EarlyView.
Abstract Circulatory shock remains difficult to manage because fluid resuscitation and catecholamines may exacerbate vascular dysfunction and tissue hypoperfusion. This prospective physiological analysis, embedded within a multicentre phase IV study, examined whether selectively targeting the venous circulation with centhaquine improves circulatory ...
Athanasios Chalkias, Aman Khanna, Krish Vaidya, Dharmesh Shah, Anil Gulati   +4 more
wiley   +1 more source

The Takotsubo Syndrome: Where the Sympathetic Stress Reflex and the Dive Reflex Conflict. [PDF]

Cureus
Hayman J, Finsterer J.
europepmc   +1 more source

Senolytics and exercise: Dual modalities for rejuvenating muscle

The Journal of Physiology, EarlyView.
Abstract figure legend The role of senolytics on the heart and skeletal muscle. Senescent cell burden increases with ageing, disuse and disease. The senolytics dasatinib+quercetin (D+Q), navitoclax and fisetin, as well as exercise, eliminate senescent cells, reducing senescent cell burden and their senescence‐associated secretory phenotype (SASP ...
Zeynep Elif Yesilyurt‐Dirican, Ce Qi, Uchenna Okpechi, Maya Strand Ford, Georgina M. Ellison‐Hughes   +4 more
wiley   +1 more source

Spontaneous Coronary Artery Dissection and Takotsubo Syndrome: Converging Mechanisms, Diagnostic Pitfalls, and a Unified Clinical Algorithm. [PDF]

J Clin Med
Golino M, Shakfeh K, Stiglich AA, Font C, Rollini F, Mahowald MK, Velarde G, Adedinsewo D, Franchi F, Zgheib A, El Khoury G, Rivas Rios J, Mollo P, Abbate A, Celeski M, Marchetta M.   +15 more
europepmc   +1 more source

Myocardial Stunning After Electrocution With Complete Reversibility Within 24 Hours: Role of Repeat Transthoracic Echocardiograms in Potential Cardiac Transplant Donors. [PDF]

Cardiol Res, 2018
Tahir H, Sachdev S, Nguyen L, Bardia N, Omar B, Cohen MV.   +5 more
europepmc   +1 more source

Born early, age fast: Consequences of premature birth on chronic disease and accelerated ageing

The Journal of Physiology, EarlyView.
Abstract figure legend ELGANs are exposed to several postnatal pro‐oxidant stressors, including ambient and supplemental oxygen, mechanical ventilation, infections, hyperalimentation, excessive glucocorticoids and intermittent hypoxia. Since endogenous antioxidant defences are underdeveloped, this imbalance promotes oxidative stress and inflammation ...
Estelle B. Gauda, Julijana Ivanovska, Dwayne Mascarenhas, Jeffrey Antwi, Atefeh Mohammadi, Bonny Jasani   +5 more
wiley   +1 more source

Takotsubo syndrome triggered by perioperative and post-resuscitation stress: Case report. [PDF]

SAGE Open Med Case Rep
Tom R, O'Leary S, Kuang K, Robledo A, Teegarden B.   +4 more
europepmc   +1 more source

The role of extracellular vesicles in cell–cell crosstalk in cardiotoxicity

The Journal of Physiology, EarlyView.
Abstract figure legend Administration of a pharmacological agent can result in off‐target cardiotoxicity which can be driven by cell–cell crosstalk between healthy and dysfunctional cardiac cells. Extracellular vesicles (EVs) are lipid bilayer structures that can move biological cargo between cells, facilitating cell–cell crosstalk.
Gabriella Bachynskyj‐Bilas, Debbie J. Otto, Daniel Stratton, Katja Rietdorf, Daniel M. Johnson, Calum J. McMullen   +5 more
wiley   +1 more source

Spontaneous Takotsubo Syndrome and Its Recurrences: Pathogenetic Role of Intraventricular Mechanical Factors. [PDF]

Circ Rep
Yalta K, Ayyıldız G, Ozkan U.
europepmc   +1 more source