Results 191 to 200 of about 337,957 (243)

Potential health benefits of cold‐water immersion: the central role of PGC‐1α

The Journal of Physiology, EarlyView.
Abstract figure legend Cold‐water immersion (CWI) elicits autonomic, somato‐motoric (shivering thermogenesis), endocrine and metabolic, sensory transduction, and local biophysical effects that may converge on the transcriptional co‐activator PGC‐1α (centre).
Erich Hohenauer, Wafa Douzi, Johannes Burtscher   +2 more
wiley   +1 more source

Current advances in 2025: A critical review of selected topics by the Association for the Advancement of Blood and Biotherapies (AABB) Clinical Transfusion Medicine Committee

Transfusion, EarlyView.
Nabiha H. Saifee, Jennifer Andrews, Mary Berg, Stella T. Chou, Mischa Covington, Elizabeth P. Crowe, Ruchika Goel, Juliana A. Guarente, Tina Ipe, Jeremy W. Jacobs, Jessica Jacobson, Cyril Jacquot, Jenna Khan, Thane A. Kubik, Theodros Mamo, Michael F. Murphy, Kerry O'Brien, Monica B. Pagano, Anil K. Panigrahi, Jacqueline N. Poston, Scott E. Potter, Simon J. Stanworth, Moritz Stolla, Alyssa Ziman, Ryan A. Metcalf   +24 more
wiley   +1 more source

Caenorhabditis elegans as an in vivo model system for human inherited primary arrhythmia syndromes

The Journal of Physiology, EarlyView.
Abstract figure legend Most genes involved in inherited primary arrhythmia syndromes (IPAS) are conserved in Caenorhabditis elegans, where genetic manipulation enables functional characterization of variants, identification of regulatory proteins, and in vivo drug testing.
Antoine Delinière, Thomas Boulin, Maëlle Jospin, Alexandre Janin, Gilles Millat, Philippe Chevalier, Olga Andrini   +6 more
wiley   +1 more source

MAPSE in critical illness: from prognostic association to clinical utility. [PDF]

Crit Care
He X, Huang Y.
europepmc   +1 more source

Scaling temporal resolution from mice to humans: Challenges and innovations in preclinical imaging of translational models

The Journal of Physiology, EarlyView.
Abstract figure legend Temporal scaling physiology differs significantly between mice and humans. Mice have higher metabolism, heart and respiratory rate, as well as faster blood flow rates, brain activity and physiological dynamics over time. These differences influence the temporal resolution needed in preclinical imaging of mouse models to ...
Sara Gargiulo, Matteo Gramanzini
wiley   +1 more source

Helium stunning system: Heliumbetäubung [PDF]

Pohůnek, Václav, Brüggemann, Dagmar Adeline, Zimmermann, Sebastian   +2 more
core  

Advanced imaging and multi‐omics to characterize cardiomyocyte ageing and its electrocardiographic imprint in PKP2 arrhythmogenic cardiomyopathy

The Journal of Physiology, EarlyView.
Abstract figure legend We used a murine model of cardiomyocyte‐specific conditional knockout of plakophilin 2 (PKP2cKO, middle panel). Using advanced imaging technology, we unveiled distinct hallmarks of premature ageing in PKP2cKO cardiomyocytes, including DNA damage and loss of repressed heterochromatin at the nuclear periphery, and mitochondrial ...
Giorgia Bertoli, Kavya Phadke, Alessandro Cospito, Xianming Lin, Marina Cerrone, Joanna Abi Rizk, Michael Cammer, Yan Deng, Joseph Sall, Mingliang Zhang, Feng‐Xia Liang, Irene de Lázaro, Mario Delmar   +12 more
wiley   +1 more source

Regional and Compartmental Changes Drive Progressive Patterns of Striatal Degeneration in X‐Linked Dystonia Parkinsonism

Annals of Neurology, Volume 100, Issue 4, Page 751-767, October 2026.
Objective Initially described in 1976, X‐linked dystonia parkinsonism (XDP) is a neurodegenerative disease that can be characterized by the presentation of dystonia and parkinsonism symptoms. Although this disease bears some resemblance to other neurodegenerative diseases in terms of symptomatology, the pathological signature of XDP is still unclear ...
Adelie Y.S. Tan, Nakhon. S.S.S. Thai, Christine J. Arasaratnam, Seung A. Han, Ellen B. Penney, Geraldine Acuña‐Sunshine, Cid Czarina E. Diesta, Mark C. Ang, Edwin Muñoz, Cara Fernandez‐Cerado, Victor Cleofas, G. Paul Legarda, Salvie Velasco, Michelle A. Sy, Clinton P. Turner, Mike Dragunow, Maurice A. Curtis, Ann. M. Graybiel, Richard L.M. Faull, Malvindar K. Singh‐Bains   +19 more
wiley   +1 more source

Electroconvulsive Therapy as a Trigger for Takotsubo Cardiomyopathy. [PDF]

J Brown Hosp Med
Nguyen MA, Montalbano G, Arikan P.
europepmc   +1 more source

Comparison of Methods for Incorporating Related Data When Developing Clinical Prediction Models: A Simulation Study

Biometrical Journal, Volume 68, Issue 5, October 2026.
ABSTRACT Clinical Prediction Models (CPMs) compute an individual's risk of an outcome, given a set of predictors. Guidance states CPMs should be constructed using data sampled from the target population. However, researchers might have access to ancillary data sets from different time points, countries, or healthcare settings, which could support model
Haya Elayan, Matthew Sperrin, Glen P. Martin, Frieder Braunschweig, Jonas Faxén, Joakim Alfredsson, David A. Jenkins   +6 more
wiley   +1 more source