Therapeutic Applications of Stimuli‐Based Release and Engineering of Extracellular Vesicles
This review summarizes the effects of endogenous and exogenous stimuli, their effects on the natural release of extracellular vesicles, as well as their uptake and release. It also gives an overview of stimuli‐responsive EVs and their therapeutic applications. Extracellular vesicles (EVs), nano‐ to microsized lipid bilayer membrane‐bound particles, are
Gloria Kemunto, Kristen Dellinger
wiley +1 more source
The effect of intravenous calcium administration on haemodynamics in perioperative cardiothoracic surgery and intensive care: A narrative review. [PDF]
Miller A +6 more
europepmc +1 more source
Aim A prior non‐randomized study suggests that potassium supplementation may improve survival among furosemide initiators, and a randomized trial suggests that salt substitutes containing potassium might lower stroke risk. We conducted a retrospective cohort study using health‐care data to confirm or refute these associations among new users of ...
Thanh Phuong Pham Nguyen +8 more
wiley +1 more source
Trigger-Negative Takotsubo Syndrome: A Distinct Phenotype Prone to Recurrence. [PDF]
Nakamura K, Hayashi K, Toda H.
europepmc +1 more source
A Phase I/II Study of Ibrutinib Plus Trastuzumab in HER2‐Positive Metastatic Breast Cancer
ABSTRACT Ibrutinib has demonstrated inhibition of ErbB/HER tyrosine kinases in preclinical models. This Phase I/II study investigated the safety, efficacy, and immunomodulatory effects of ibrutinib in combination with trastuzumab in patients with HER2‐positive metastatic breast cancer (MBC) whose disease had progressed on ado‐trastuzumab emtansine ...
Joyce O'Shaughnessy +10 more
wiley +1 more source
Extracorporeal Life Support in Severe Accidental Hypothermia: Mechanisms, Challenges and Clinical Horizons. [PDF]
Torre DE, Pirri C.
europepmc +1 more source
ABSTRACT Background Transcatheter edge‐to‐edge repair (TEER) has become an established therapeutic option for patients with severe secondary mitral regurgitation (SMR). While randomized trials and registry data have reported outcomes up to 5 years, longer follow‐up data remain scarce.
Tobias Reithmayer +9 more
wiley +1 more source
Role of Neuroimaging Before Coronary Angiography in Patients With Out‐of‐Hospital Cardiac Arrest
ABSTRACT Background Patients presenting following out‐of‐hospital cardiac arrest (OOHCA) often require emergency coronary angiography. Presentations can be associated with syncope or head‐trauma. Aims We investigated the impact and utility of pre‐coronary angiography CT‐Brain (CT‐B) in patients following OOHCA on clinical outcomes.
Edmond Wong +8 more
wiley +1 more source
Isolated Right Ventricular Takotsubo Cardiomyopathy: Beyond the Left Ventricle. [PDF]
Takagi MA +6 more
europepmc +1 more source
Atorvastatin‐Associated Severe Bradyarrhythmia Following Multiorgan Dysfunction: A Case Report
ABSTRACT Statins are the primary treatment for hypercholesterolemia and a cornerstone of atherosclerotic cardiovascular disease prevention. Although generally safe, serious adverse effects may occur in selected patients, particularly when statins are used at high doses or without medical supervision.
Xiao‐Qing Kou +5 more
wiley +1 more source

