Results 141 to 150 of about 206,512 (311)

Diffuse Myocardial Injury With Diabetes-Related Advanced Glycation End Product Accumulation in Dilated Cardiomyopathy: Pathological Insights From an Autopsy Case. [PDF]

Cureus
Kitazawa S, Kitazawa R.
europepmc   +1 more source

Influence of phorbol-12,13-dibutyrate on the α1-adrenoceptor-mediated positive inotropic effect in the rabbit ventricular myocardium.

, 1989
Jun Otomo, Ikuo Norota, Masao Endoh
openalex   +1 more source

Pharmacological characteristics of the positive inotropic effect of angiotensin II in the rabbit ventricular myocardium [PDF]

, 1993
Akira Ishihata, Masao Endoh
openalex   +1 more source

XIAP Stabilizes DDRGK1 to Promote ER‐Phagy and Protects Against Noise‐Induced Hearing Loss

Advanced Science, EarlyView.
Mechanism of GAS‐mediated protection against noise‐induced hearing loss (NIHL). Noise exposure activates the ATF4/eIF2α axis, downregulating XIAP and promoting DDRGK1 degradation, thereby inhibiting ER‐phagy and leading to hair cell (HC) death. GAS treatment rescues XIAP and DDRGK1 expression, reactivating ER‐phagy to mitigate HC loss, synaptic damage,
Lin Yan, Yuhua Zhang, Jiawei Du, Yongjun Zhu, Wei Cao, Yongjie Wei, Han Wu, Shiyu Qiu, Shiyi Pan, Lian Chen, Pingping Liang, Renjie Chai, Jianming Yang, Qiaojun Fang   +13 more
wiley   +1 more source

Integrated motion-corrected extracellular volume fraction mapping reveals subtle extracellular remodeling in remote myocardium following chronic myocardial infarction. [PDF]

BMC Med Imaging
Wang W, She T, Wang Y, Wang F, Wang M, Xu S, Duan X, Yang L.   +7 more
europepmc   +1 more source

Promoting Autophagy Mitigates Stress‐Induced Remodeling in Patient iPSC‐CMs with the Phospholamban R9C Mutation

Advanced Science, EarlyView.
The Phospholamban (PLN) R9C mutation reduces SERCA2a binding, increasing calcium recycling and baseline contractility. However, the excess of free PLN promotes pentamer formation, limiting phosphorylation and blunting β‐adrenergic signaling. Under cardiac stress, enhanced functional demands overwhelm proteostasis in PLN R9C cells, leading to misfolded ...
Qi Yu, Yawei Shen, Robert J. Barndt, Karim Sallam, Ying Tang, Cameron E. Brown, Xiao Li, Stephen Y. Chan, Joseph C. Wu, Qing Liu, Haodi Wu   +10 more
wiley   +1 more source

AI-powered SPOT imaging for enhanced myocardial scar detection and quantification. [PDF]

Nat Commun
Bustin A, Stuber M, de Villedon de Naide V, Villegas-Martinez M, Narceau K, Génisson T, Richard T, Gut P, Ozenne V, Constantin M, Caluori G, Vlachos K, Montier G, Pasche D, Bedague T, Maes JD, Sridi S, Bazin C, Dournes G, Clément-Guinaudeau S, Ben Lala I, Hocini M, Montaudon M, Jaïs P, Cochet H.   +24 more
europepmc   +1 more source

Activating the Osteoblastic USP26 Pathway Alleviates Multi‐Organ Fibrosis by Decreasing Insulin Resistance

Advanced Science, EarlyView.
The loss of Ubiquitin Specific Peptidase 26 (USP26) in osteoblasts results in decreased bone formation, as well as multi‐organ fibrosis associated with insulin resistance (IR). Mechanistically, the absence of USP26 reduces glycolysis and lactate accumulation, leading to decreased histone H3 lysine 18 lactylation (H3K18LA) in the promoter region of KH ...
Jiyuan Tang, Wenkai Ye, Liang He, Zhou Dan, Leilei Chang, Zijie You, Yuanyue Jiang, Guoqing Tang, Lianfu Deng, Changwei Li   +9 more
wiley   +1 more source

Technetium-99m-labeled pyrophosphate uptake in the rectum of a patient with wild-type transthyretin cardiac amyloidosis. [PDF]

Radiol Case Rep
Takahashi K, Sasaki D, Yamamoto S, Yamamura N, Utsunomiya Y, Morioka H, Uemura S, Sakaue T, Inoue K.   +8 more
europepmc   +1 more source

In vitro and in vivo studies of1H NMR visibility to detect deoxyhemoglobin and deoxymyoglobin signals in myocardium [PDF]

, 1999
Wei Chen, Yong‐Yeon Cho, Hellmut Merkle, Yun Ye, Yi Zhang, Guangrong Gong, Jianyi Zhang, Kâmil Uǧurbil   +7 more
openalex   +1 more source