Results 271 to 280 of about 333,235 (350)

Single Mitochondrion Morphology‐Function Relationship Analysis Using Fluorescent Probes and Artificial Intelligence

Advanced Science, EarlyView.
An integrated strategy combining a mitochondria‐targeted fluorescent probe set and an AI framework enables simultaneous analysis of mitochondrial morphology and function at the single organelle level. By fusing multi‐parametric features, machine learning classification accurately distinguishes individual mitochondria under hypoxia‐related conditions ...
Yang Ding, Bin Fang, Qingzhe Li, Biying Zhang, Jintao Li, Hua Bai, Nicolas H. Voelcker, Bo Peng, Xuekang Yang, Lin Li   +9 more
wiley   +1 more source

Sox9 in the epicardium: Implications for cell invasion, differentiation, and coronary vascular development. [PDF]

PLoS One
Harvey AB, Trouten AM, Wolters RA, Drummond JR, Deepe RN, Tarolli HG, Devji I, Vaena SG, Romeo MJ, Muise-Helmericks R, Ramos PS, Norris RA, Tao G, Wessels A.   +13 more
europepmc   +1 more source

Regulating Enzyme Activity via Microaggregates Mediated by Phase Separation

Advanced Science, EarlyView.
An enzyme‐sequestration strategy for combating postoperative pancreatic fistula (POPF) is developed, employing a D‐peptide called DPMD to induce liquid–solid phase separation (LSPS) of pancreatic proteases. This LSPS‐driven microaggregate approach effectively isolates trypsin and chymotrypsin from their substrates, thereby reducing pancreatic fluid ...
Yang Wang, Juzheng Yuan, Niu Dai, Yanlin Ji, Wenguang Yang, Xiao Li, Siqi Yan, Jin Yan   +7 more
wiley   +1 more source

Cardiac MRI of differing ischemia and reperfusion times in a myocardial infarction pig model. [PDF]

Sci Rep
Boll D, Reiss S, Schmitz HRC, Weber C, Thielmann J, Spreter F, Mehr KT, Chiang D, Jäckel M, Heger L, Rilinger J, Westermann D, von Zur Mühlen C, Heidt T, Bock M, Maier A.   +15 more
europepmc   +1 more source

Inhibition of Macrophage ARID3A Alleviates Myocardial Ischemia‐Reperfusion Injury After Heart Transplantation by Reducing THBS1/CD47 Signaling‐Mediated Neutrophil Extracellular Traps Formation

Advanced Science, EarlyView.
This study reveals that ARID3A in macrophages can transcriptionally regulate the THBS1‐CD47 axis after heart transplantation (HT), thereby inducing activated neutrophils to release NETs through the p38 MAPK signaling pathway. The itaconate derivative 4‐OI can inhibit ARID3A in macrophages and promote the accumulation of antioxidant factors, thereby ...
Hao Tian, Yonghong Xiong, Junbiao Zhan, Zhikun Lu, Yuxi Zhang, Yan Leng, Qin Huang, Zhongyuan Xia   +7 more
wiley   +1 more source

Saw-tooth cardiomyopathy from foetal to neonatal period: a case report and literature review. [PDF]

Eur Heart J Case Rep
Lv Z, Yang Y, Wang Z, Yang J, Xiao Y.
europepmc   +1 more source

Modulation of Aging Diseases via RAGE Targets: A Dietary Intervention Review

Advanced Science, EarlyView.
This paper analyzes RAGE ligand‐binding mechanisms and signaling, proposing intervention strategies targeting these interactions. It emphasizes dietary polyphenols, polysaccharides, and terpenoids delivered via functional foods for anti‐aging. These compounds offer long‐term, safe intervention through dietary supplementation, providing dual nutritional
Qian Wu, Jia Yan, Yuyan Zhang, Xiaozhi Ming, Siqi Chen, Zhichao Zou, Nianjie Feng, Jianbo Xiao   +7 more
wiley   +1 more source

The Congenital Malformation of the Interatrial Septum-A Review of Its Development and Embryology with Clinical Implications. [PDF]

J Dev Biol
Oliveira RC, Martins P, Martins MF.
europepmc   +1 more source

Open Challenges and Opportunities in Piezoelectricity for Tissue Regeneration

Advanced Science, EarlyView.
This review provides an intriguing review of the recent advancements, challenges, and future perspectives regarding the application of piezoelectric scaffolds in tissue regeneration. The detailed exposition is anticipated to propel the advancement of personalized and intelligent piezoelectric implants, thereby fostering significant progress in this ...
Xiaoling Deng, Yu Zhuang, Jinjie Cui, Liyun Wang, Huilu Zhan, Xudong Wang, Kaili Lin, Changyong Yuan   +7 more
wiley   +1 more source