Results 51 to 60 of about 342,256 (353)

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

Specific Inhibition of CYP4A Alleviates Myocardial Oxidative Stress and Apoptosis Induced by Advanced Glycation End-Products

Frontiers in Pharmacology, 2019
High exposure to advanced glycation end-products (AGEs) may induce cardiotoxicity. However, the effects and mechanisms remain to be further clarified.
Rui Wang, Rui Wang, Li Wang, Jinlong He, Shanshan Li, Xiaojing Yang, Pengyuan Sun, Yuhui Yuan, Jinyong Peng, Jinsong Yan, Jianling Du, Hua Li   +11 more
doaj   +1 more source

Myocardial trabeculation in embryos of Scyliorhinus canicula (Elasmobranchii, Chondrichthyans) [PDF]

, 2018
Currently, three types of ventricular myoarchitecture are recognized in vertebrates, namely compact, spongy (trabeculated) and mixed myocardium. Mixed myocardium, which has been recently proposed as the primitive condition in gnathostomes, is composed of
Durán-Boyero, Ana Carmen, Fernández-Corujo, Borja, Lorenzale, Miguel, López-Unzu, Miguel A., Rodríguez, Cristina   +4 more
core  

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source

ShengMai-San Attenuates Cardiac Remodeling in Diabetic Rats by Inhibiting NOX-Mediated Oxidative Stress

Diabetes, Metabolic Syndrome and Obesity, 2021
Yanting Lu, Shu Zhu, Xiaoyan Wang, Juhai Liu, Yingying Li, Wei Wang, Shijun Wang, Furong Wang College of TCM, Shandong University of Traditional Chinese Medicine, Jinan, 250355, People’s Republic of ChinaCorrespondence: Shijun Wang; Furong Wang ...
Lu Y, Zhu S, Wang X, Liu J, Li Y, Wang W, Wang S, Wang F   +7 more
doaj  

Gender characteristics of retinal parameters in patients with uncomplicated hypertension

Кардиоваскулярная терапия и профилактика, 2020
Aim. To establish gender specificities of retinal arteriolar and venular diameters, foveal avascular zone (FAZ) area, subfoveal choroid thickness (SCT), and to determine their association with cardiovascular risk and prognosis in patients with ...
A. V. Barsukov, K. A. Shcherbakova, M. A. Burnasheva, D. S. Maltsev, A. N. Kulikov, A. E. Korovin, M. V. Yasenovets, A. V. Gordienko   +7 more
doaj   +1 more source

Graft preservation confers myocardial protection during coronary artery bypass grafting

Frontiers in Cardiovascular Medicine, 2022
BackgroundDuring on-pump coronary artery bypass grafting (ONCAB), graft flushing for distal anastomoses testing also perfuses the downstream myocardium.
Philipp Szalkiewicz, Maximilian Y. Emmert, Maximilian Y. Emmert, Paul P. Heinisch, Zsuzsanna Arnold, Zsuzsanna Arnold, Ingo Crailsheim, Ingo Crailsheim, Markus Mach, Markus Mach, Thomas Aschacher, Thomas Aschacher, Thomas Aschacher, Martin Grabenwöger, Martin Grabenwöger, Martin Grabenwöger, Bernhard Winkler, Bernhard Winkler, Bernhard Winkler   +18 more
doaj   +1 more source

Detection of myocardial scar from the VCG using a supervised learning approach [PDF]

, 2013
This paper addresses the possibility of detecting presence of scar tissue in the myocardium through the in- vestigation of vectorcardiogram (VCG) characteristics.
Dima, Sofia-Maria, Gialelis, John, Maharatna, Koushik, Mazomenos, Evangelos B., Morgan, John M., Panagiotou, Christos, Rosengarten, James   +6 more
core   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Advances in magnetic resonance imaging of the myocardial area at risk and salvage [PDF]

, 2016
No abstract ...
Berry, Colin, Mangion, Kenneth
core   +1 more source