Results 51 to 60 of about 338,002 (352)
HSP70 governs permeability and mechanotransduction in primary human endothelial cells
FEBS Open Bio, EarlyView.HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez +5 more
wiley +1 more source
Advances in magnetic resonance imaging of the myocardial area at risk and salvage [PDF]
, 2016 No abstract ...
Berry, Colin, Mangion, Kenneth
core +1 more source
Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays
FEBS Open Bio, EarlyView.We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul +3 more
wiley +1 more source
Molecules, 2019 Out-of-hospital sudden cardiac arrest is a major public health problem with an overall survival of less than 5%. Upon cardiac arrest, cessation of coronary blood flow rapidly leads to intense myocardial ischemia and activation of the sarcolemmal Na+-H ...
Raúl J. Gazmuri +2 more
doaj +1 more source
Cardio-sarcopenia: A syndrome of concern in aging
Frontiers in Medicine, 2022 Cardiac alterations in structure and function, namely, the left ventricle, have been intensely studied for decades, in association with aging. In recent times, there has been keen interest in describing myocardial changes that accompany skeletal muscle ...
De Rong Loh +6 more
doaj +1 more source
Analysis of left ventricular behaviour in diastole by means of finite element method [PDF]
, 1979 The human left ventricle in diastole can be modelled as a passive structure with incremental internal pressure change being considered as the load. Recent developments in engineering stress analysis provide techniques for predicting the behaviour of ...
Gibson, DG, Vinson, CA, Yettram, AL
core +2 more sources
FEBS Open Bio, EarlyView.Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp +13 more
wiley +1 more source
Puerarin: A protective drug against ischemia-reperfusion injury
Frontiers in Pharmacology, 2022 Ischemia-reperfusion (I/R) is a pathological process that occurs in numerous organs throughout the human body and is frequently associated with severe cellular damage and death.
Minglang Gao +6 more
doaj +1 more source
Myocardial trabeculation in embryos of Scyliorhinus canicula (Elasmobranchii, Chondrichthyans) [PDF]
, 2018 Currently, three types of ventricular myoarchitecture are recognized in vertebrates, namely compact, spongy (trabeculated) and mixed myocardium. Mixed myocardium, which has been recently proposed as the primitive condition in gnathostomes, is composed of
Durán-Boyero, Ana Carmen +4 more
core
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Recurrent high‐grade gliomas have a poor prognosis and limited therapeutic options. This study aimed to evaluate the safety and efficacy of SYHA1813, a dual inhibitor of VEGFR and CSF1R, in patients with recurrent high‐grade gliomas.
Zhuang Kang +16 more
wiley +1 more source