Ploidy‐Dependent Response to Anticancer Drugs of Human Embryonic Stem Cells
Cell Proliferation, EarlyView.Using isogenic hESCs, differing only in their ploidy level, we show the effect of ploidy on the resistance to anticancer drugs. We demonstrate that polyploidy, by itself, confers sensitivity to chemotherapies, leading to higher apoptosis and delayed proliferation, while the loss of p53 reverses the phenotype, demonstrating higher resistance.
Guy Haim‐Abadi, Nissim Benvenisty
wiley +1 more source
Diabetes, Obesity and Metabolism, EarlyView.ABSTRACT Background Distal symmetrical polyneuropathy (DSPN) is a common complication of type 1 diabetes (T1D), yet validated biomarkers for early detection or prognosis are lacking. Metabolic disturbances driven by chronic hyperglycemia and dyslipidemia contribute to DSPN development and progression.
Tik Muk +18 more
wiley +1 more source
Histological evaluation of clinically defined atrial cardiomyopathy stages and their association with atrial fibrillation burden under continuous monitoring for a 2.5-year follow-up. [PDF]
EuropaceWinters J +11 more
europepmc +1 more source
The FEBS Journal, EarlyView.Chd4/NuRD and ThPOK cooperate to maintain transcriptional repression and nuclear organization in adult cardiomyocytes. Chd4 loss reduces miR‐150‐5p, relieving repression of Sprr1a, while ThPOK loss further enhances Sprr1a activation, possibly through altered chromatin–lamina interactions.
Fadoua El Abdellaoui‐Soussi +12 more
wiley +1 more source
Establishing Primary Cultures of Adult Mouse Cardiac Fibroblasts: A Comparative Evaluation of Three Experimental Protocols. [PDF]
Int J Mol SciNastase-Rusu EG +3 more
europepmc +1 more source
The epigenetic landscape of skeletal muscle in response to exercise and aging
The FEBS Journal, EarlyView.Epigenetic mechanisms regulate gene expression in response to exercise and aging, thereby supporting skeletal muscle plasticity. Acute exercise induces chromatin remodeling through histone modifications and DNA methylation, promoting the expression of exercise‐responsive genes.
Sabrina Champsi, David A. Hood
wiley +1 more source
When does the Human Heart Transition from Hyperplastic Myocyte Growth to Myocyte Hypertrophy?
Cardiology Discovery, 2021 A Martin Gerdes, Tianyu Xu, Xiaoxia Fu.
doaj +1 more source
Comparative Analysis of Calcareous Corpuscle Morphogenesis in Amphilinideans and Eucestodes, With Insights Into Some Atypical Ultrastructural Characteristics of the Amphilinidea (Cestoda). [PDF]
J MorpholPoddubnaya LG, Gibson DI.
europepmc +1 more source
The FEBS Journal, EarlyView.Trim32 regulates the transition from proliferation to differentiation in C2C12 cells after myogenic induction. We found that, at the onset of differentiation, Trim32 destabilizes c‐Myc mRNA, promotes cell cycle exit, and enables normal myotube formation.
Lu Xiong +6 more
wiley +1 more source
Modular Tissue-Engineered Motor Units Featuring Spinal Motor Neurons Innervating Self-Assembled Myofiber Bundles. [PDF]
Macromol BiosciHilman MC +4 more
europepmc +1 more source