Results 101 to 110 of about 78,026 (273)
Catheterization and Cardiovascular Interventions, EarlyView.ABSTRACT Background Electrocardiographic parameters have emerged as valuable noninvasive markers for risk stratification in acute coronary syndrome (ACS). Aims This study aimed to evaluate the correlation between R wave peak time (RWPT) and coronary artery disease (CAD) severity, and to assess its prognostic value for in‐hospital major adverse cardiac ...
Jilin Xu +5 more
wiley +1 more source
Cytoskeleton, EarlyView.ABSTRACT Sarcomeres are the fundamental contractile units of striated muscle. The functional roles of the cardiac‐specific myosin heavy chains, MYH6 (α myosin II) and MYH7 (β myosin II) during sarcomere assembly remain controversial. To address this, we utilized a selective MYH7 inhibitor, mavacamten, in combination with siRNA‐mediated knockdown of ...
James B. Hayes, Dylan T. Burnette
wiley +1 more source
Frontiers in Physiology, 2012 Diabetic heart disease is a distinct clinical entity that can progress to heart failure and sudden death. However, the mechanisms responsible for the alterations in excitation-contraction coupling leading to cardiac dysfunction during diabetes are not ...
Allyson eKranstuber +6 more
doaj +1 more source
Genetically engineered cardiac pacemaker: stem cells transfected with HCN2 gene and myocytes - a model [PDF]
arXiv, 2005 Artificial biological pacemakers were developed and tested in canine ventricles. Next steps will require obtaining oscillations sensitive to external regulations, and robust with respect to long term drifts of expression levels of pacemaker currents and gap junctions. We introduce mathematical models intended to be used in parallel with the experiments.
arxiv
Cytoskeleton, EarlyView.ABSTRACT Actin filaments are dynamic polymers whose length depends on regulated monomer association and dissociation at their ends. Actin barbed‐end dynamics are relatively better understood, primarily due to the approximately tenfold faster subunit on/off rates at barbed versus pointed ends.
Sawako Yamashiro +5 more
wiley +1 more source
Iranian Journal of Allergy, Asthma and Immunology, 2009 Viral myocarditis is a common cardiovascular disease, which has greatly threatened human health. However, up to now, the pathogenesis of viral myocarditis has been unclear, which leads to the lack of its effective treatments.
Shen Yan +3 more
doaj
Diabetes Increases the Vulnerability of the Cardiac Mitochondrial Network to Criticality
Frontiers in Physiology, 2020 Mitochondrial criticality describes a state in which the mitochondrial cardiac network under intense oxidative stress becomes very sensitive to small perturbations, leading from local to cell-wide depolarization and synchronized oscillations that may ...
Larissa Vetter +14 more
doaj +1 more source
Devil's staircase inside shrimp-shaped regions reveals periodicity of plateau spikes and bursts [PDF]
Slow-fast dynamics are intrinsically related to complex phenomena and are responsible for many of the homeostatic dynamics that keep biological systems healthy functioning. We study a discrete-time membrane potential model that can generate a diverse set of spiking behavior depending on the choice of slow-fast time scales, from fast spiking to bursting,
arxiv +1 more source
ChemMedChem, EarlyView.Work presented here details the design and characterize novel G protein‐gated inwardly rectifying potassium channels (GIRK)1/2 activators. A new 4,4‐difluorocyclohexylpyrazole have been identified that confers improved potency and selectivity for GIRK1/2 versus GIRK1/4.
Sumaiya Nahid +8 more
wiley +1 more source
Dynamic re-wiring of protein interaction: The case of transactivation [PDF]
arXiv, 2006 We are looking at local protein interaction networks from the perspective of directed, labeled graphs with quantitative values for monotonic changes in concentrations. These systems can be used to perform stability analysis for a stable attractor, given initial values.
arxiv