Results 131 to 140 of about 141,107 (310)

Micro Pattern‐Based 3D Cell Culture Platform: An Overview of Technologies and Applications

Exploration, EarlyView.
Micro patterns are characterized as a coating of specific adhesion matrices on substrates to support cell growth. An overview of micropattern technology to regulate single cell morphology and fates, further focusing on the micro pattern‐based 3D cell culture platform used in the non‐tumor and tumor researches.
Xinglong Zhu, Yi Li, Hulin Long, Yijia Wu, Ningwei Sun, Shun Li, Yiyao Liu, Huiqi Xie, Ji Bao   +8 more
wiley   +1 more source

Phytochemicals and Health Benefits of American Ginseng (Panax quinquefolius L.): Current Knowledge and Future Perspectives

Food Safety and Health, EarlyView.
This review summarizes the chemical constituents and functional characteristics of American ginseng, aiming to provide references for its development and application. ABSTRACT American ginseng, a perennial herbaceous plant, is recognized for its significant medicinal properties and has attracted considerable attention due to its diverse phytochemical ...
Wei Geng, Ning Zhou, Jinqian Yu, Yanling Geng, Xiao Wang, Yannan Chen   +5 more
wiley   +1 more source

Genetically engineered cardiac pacemaker: stem cells transfected with HCN2 gene and myocytes - a model

, 2005
Artificial biological pacemakers were developed and tested in canine ventricles. Next steps will require obtaining oscillations sensitive to external regulations, and robust with respect to long term drifts of expression levels of pacemaker currents and ...
Kanani, Sandra, Krinsky, Valentine, Pumir, Alain   +2 more
core  

Cell Death in the Cardiac Myocyte

Biological & Pharmaceutical Bulletin, 2015
Loss of cardiac myocytes plays a critical role in the pathogenesis of cardiovascular disorders. A decrease in the number of cardiac myocytes in cardiac diseases results in sustained, irreversible contractile failure of myocardium. Therefore prevention of cardiac cell death is a potential therapeutic strategy for various heart diseases.
Tetsuro, Marunouchi, Kouichi, Tanonaka
openaire   +3 more sources

The Role and Therapeutic Potential of Voltage‐Gated Potassium Channel Kv1.3 in Metabolism‐Related Disorders

iNew Medicine, EarlyView.
ABSTRACT Over the past three decades, the global burden of common metabolic diseases such as obesity, diabetes, and atherosclerosis has steadily increased, becoming a serious public health issue that poses a major threat to human health worldwide. Potassium channels, particularly the voltage‐gated Kv1.3 subtype, serve as critical regulators of cellular
Wenjun Zhen, Junda Liu, Xixi Chen, Shi Chen, Yuanyuan Tian, Baoming Wu, Fengxia Yan   +6 more
wiley   +1 more source

Cardioprotective effect of spirulina on cafeteria diet‐induced cardiac injury in silico and in vivo study

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Obesity is a major risk factor for cardiovascular disease, primarily due to its effects on lipid metabolism, oxidative stress, and inflammation. The aim of this study was to evaluate the effects of spirulina (SP) on cafeteria diet (CD)‐induced myocardial oxidative stress and inflammation using biochemical, histological, and in ...
Fatma Arrari, Mohamed‐Amine Jabri, Imen Hammami, Hichem Sebai   +3 more
wiley   +1 more source

Repair of Mybpc3 mRNA by 5′-trans-splicing in a Mouse Model of Hypertrophic Cardiomyopathy

Molecular Therapy: Nucleic Acids, 2013
RNA trans-splicing has been explored as a therapeutic option for a variety of genetic diseases, but not for cardiac genetic disease. Hypertrophic cardiomyopathy (HCM) is an autosomal-dominant disease, characterized by left ventricular hypertrophy (LVH ...
Giulia Mearini, Doreen Stimpel, Elisabeth Krämer, Birgit Geertz, Ingke Braren, Christina Gedicke-Hornung, Guillaume Précigout, Oliver J Müller, Hugo A Katus, Thomas Eschenhagen, Thomas Voit, Luis Garcia, Stéphanie Lorain, Lucie Carrier   +13 more
doaj   +1 more source

Two causes of COVID‐19‐related myocardial injury‐associated cardiogenic shock: Myocarditis and microvascular thrombosis

ESC Heart Failure, Volume 12, Issue 2, Page 1514-1522, April 2025.
Takamasa Iwai, Hirohiko Aikawa, Yoshiaki Morita, Keiko Ohta‐Ogo, Teruo Noguchi   +4 more
wiley   +1 more source

Lipofuscin: The Missing Link in the Worsening of Obstructive Sleep Apnea

The Laryngoscope, EarlyView.
Lipofuscin, also known as the age pigment, is a permanent autofluorescent intracellular deposit that accumulates with aging or oxidative stress, thereby interfering with cellular function. This study revealed significantly larger deposits of lipofuscin in the lateral pharyngeal wall muscles of patients with severe obstructive sleep apnea (OSA) compared
Kristine Fahl, Carlos Modesto Vera Palomino, Mauricio da Silva Baptista, Adriano Polican Ciena, Danielle Andrade da Silva Dantas, Luiz Ubirajara Sennes, Marucia Chacur, Michel Burihan Cahali   +7 more
wiley   +1 more source

Amentoflavone, a Preferentially TGF‐β Receptor 1 Inhibitor, Alleviates Cardiac Remodeling and Dysfunction Through Modulating the TGF‐β/Smad and MAPK Signaling Pathways

Phytotherapy Research, EarlyView.
Amentoflavone, a preferentially TGF‐ββ receptor 1 inhibitor, attenuates transverse aortic constriction (TAC)‐triggered cardiac hypertrophy, fibrosis, and dysfunction by suppressing downstream Smad and MAPK signaling cascades in cardiomyocytes and cardiac fibroblasts.
Jiangjiao Wu, Chengcheng Zhao, Xiaoping Li, Xinyi Guo, Wenjie Tan, Lu Zhou, Ye Zhang, Jianli Zhang, Shuo Zheng, Chunyu Zeng, Gengze Wu   +10 more
wiley   +1 more source