Results 131 to 140 of about 78,026 (273)
Multiomics insight into the role of glucagon‐like peptide‐1 receptor agonists in heart failure
ESC Heart Failure, EarlyView.Graphical abstract of the multiomics insight into the role of GLP1Ra in cardiovascular diseases and the underlying pathway. GLP1Ra, glucagon‐like peptide‐1 receptor agonist. Abstract Aims Cardiovascular diseases, such as atrial fibrillation, coronary artery disease, heart failure (HF) and ischaemic stroke, are leading causes of death globally and exert
Yuhang Tao +6 more
wiley +1 more source
Stochastic resonance of ELF-EMF in voltage-gated channels: the case of the cardiac I_Ks potassium channel [PDF]
arXiv, 2009 We applied a periodic magnetic field of frequency 16 Hz and amplitude 16 nT to a human I_Ks channel, expressed in a Xenopus oocyte and varied the membrane depolarization between -100 mV and +100 mV. We observed a maximal increase of about 9% in the potassium current at membrane depolarization between 0 mV and 8 mV (see Figure 3).
arxiv
ESC Heart Failure, EarlyView.The METAB‐HTX trial is a prospective cohort study, evaluating cardiac and systemic metabolism among heart transplant recipients. Myocardial function, energetic and metabolism, allograft vasculopathy, allograft rejection, glucometabolism, lipometabolism, liver‐ and kidney function, leucocyte signatures and thromboinflammation will be evaluated ...
Amin Polzin +21 more
wiley +1 more source
Microvascular obstruction in cardiac amyloidosis
European Journal of Heart Failure, EarlyView.Abstract Aims Cardiac amyloidosis (CA) is characterized by deposition of amyloid fibrils within the extracellular space, causing disarray of the myocardial structure and capillary architecture. This study aims to characterize the prevalence of microvascular obstruction (MVO) in patients with CA and to assess the association between MVO and prognosis ...
Lucrezia Netti +19 more
wiley +1 more source
ESC Heart Failure, Volume 12, Issue 2, Page 1514-1522, April 2025.
Takamasa Iwai +4 more
wiley +1 more source
Current and novel biomarkers in cardiogenic shock
European Journal of Heart Failure, EarlyView.A summary of current and novel biomarkers and their potential stages of release in cardiogenic shock. The diagram illustrates the proposed release of the biomarkers during the different stages of cardiogenic shock: progression from cardiac dysfunction/stress, through to inflammation and end‐organ dysfunction.
Victor Galusko +5 more
wiley +1 more source
European Journal of Heart Failure, EarlyView.The analysis workflow, findings and potential clinical consequences of iron deficiency in heart failure (HF). From 881 patients with worsening HF, whole blood transcriptome was analysed using the Affymetrix Human Transcriptome Array (HTA) 2.0. Subjects were stratified according to their transferrin saturation (TSAT) levels as iron‐deficient (TSAT <20%)
Niels Grote Beverborg +17 more
wiley +1 more source
European Journal of Heart Failure, EarlyView.New anticancer therapies with potential cardiovascular side effects are continuously being introduced into clinical practice, with new and often unexpected toxicities becoming apparent only after clinical introduction. These unknown toxicities should be identified and understood beforehand to better prepare patients and physicians, enabling the ...
Alessandra Ghigo +22 more
wiley +1 more source
Cardioprotective effects of semaglutide on isolated human ventricular myocardium
European Journal of Heart Failure, EarlyView.Semaglutide reduces late sodium current (INa) and diastolic calcium (Ca) sparks in human cardiomyocytes from aortic stenosis (AS) and end‐stage heart failure with reduced ejection fraction (HFrEF) patients, thereby increasing Ca transients. Improved Ca storage may underly the enhanced contractility of human cardiomyocytes upon semaglutide.
Thomas Krammer +16 more
wiley +1 more source
European Journal of Heart Failure, EarlyView.Abstract A better understanding of additional mechanisms of heart failure (HF) progression may allow a different and more complete phenotyping of the disease and identification of novel therapeutic targets. Persistent latent myocardial inflammation/immune activation in HF may represent an attempt to restore tissue homeostasis in the failing heart ...
Gabriele Fragasso +20 more
wiley +1 more source