Results 141 to 150 of about 81,793 (268)

Repolarization adaptation to rapid change in heart rate in human models – a review

The Journal of Physiology, EarlyView.
Abstract figure legend This review focuses on non‐invasive assessment of repolarization duration and dispersion (heterogeneity) adaptation to change in heart rate (HR). HR was increased incrementally by left atrial pacing during an electrophysiology (EP) study and by a bolus injection of atropine and in a step up/down fashion by repeated right atrial ...
Lennart Bergfeldt, Karl‐Jonas Axelsson, Pia Dahlberg, Farzad Vahedi, Gunilla Lundahl, Lennart Gransberg   +5 more
wiley   +1 more source

Contribution of Cardiac CD34⁺ Stromal Cells to Post-Myocardial Infarction Repair in Middle-Aged Rats. [PDF]

J Histochem Cytochem
Schneider DT, Dedkov EI.
europepmc   +1 more source

Development of a protein synthesis network at the sarco/endoplasmic reticulum in adult cardiac myocytes

The Journal of Physiology, EarlyView.
Abstract figure legend Spatial integration of the sarcoplasmic reticulum and protein synthesis machinery in mature cardiac muscle: a schematic of the sarco/endoplasmic reticulum network in a cardiac myocyte, depicting the integrated relationships between the perinuclear endoplasmic reticulum (ER) (A), the sarcoplasmic reticulum (SR) (B), and the ...
Christoph Sandmann, Sören Brandenburg, Dennis Uhlenkamp, Bianca Meyer, Clara Sandmann, Nicole Herzog, Julia Groß, Charlotta Funaya, Hugo A. Katus, Stephan E. Lehnart, Christopher C. Glembotski, Mirko Völkers, Shirin Doroudgar   +12 more
wiley   +1 more source

JNK2 Is a Stress Integrator Driving Atrial Fibrillation Pathogenesis in Aging via Gut-Heart Crosstalk. [PDF]

Circulation
Yan J, Carrillo E, Kohli A, Khanal S, Ricchiuti N, DeSantiago J, Wan X, Han M, Richardson A, Yang M, Rondon J, Shen L, Sun J, Liang Q, Hund TJ, Meller J, Deschenes I, Bare DJ, Ai X.   +18 more
europepmc   +1 more source

Deciphering pro‐arrhythmogenic mechanisms of EPAC in human atrial cardiomyocytes

The Journal of Physiology, EarlyView.
Abstract figure legend This study aimed to investigate the effect of exchange proteins directly activated by cAMP (EPAC) on the regulation of human atrial cardiomyocyte electrophysiology and their potential involvement in the onset of atrial fibrillation (AF).
Arthur Boileve, Margaux Aize, Maximin Détrait, Laura Brard, Adrien Leboyer, Pierre‐Antoine Dupont, Alexandre Lebrun, Vladimir Saplacan, Christophe Simard, Fabien Brette, Frank Lezoualc'h, Laurent Sallé   +11 more
wiley   +1 more source

Restoration of mitochondrial Ca²⁺ and redox homeostasis by enhancement of SK channels rescues Ca²⁺ cycling in HFpEF cardiomyocytes. [PDF]

J Mol Cell Cardiol
Hamilton S, Terentyeva R, Veress R, Perger F, Loyo V, Gorr MW, Owusu-Sarfo J, Quiggle S, Gyorke S, Scherr D, Clements RT, Ljubojevic-Holzer S, Radwański PB, Singh H, Terentyev D, Belevych AE.   +15 more
europepmc   +1 more source

Computational modelling of cardiac fibroblast signalling reveals a key role for Ca2+ in driving atrial fibrillation‐associated fibrosis

The Journal of Physiology, EarlyView.
Abstract figure legend A pre‐existing fibroblast signalling model was enhanced by integrating atrial‐specific components and reactions linked to atrial fibrosis and atrial fibrillation (AF). The analysis highlights the central role of Ca2⁺ signalling in driving profibrotic responses to AF‐relevant stimuli, angiotensin‐II and transforming growth factor ...
Najme Khorasani, Haibo Ni, Jeffrey J Saucerman, Dobromir Dobrev, Stefano Morotti, Eleonora Grandi   +5 more
wiley   +1 more source

Cardiac fibroblasts in myocardial injury and heart failure. [PDF]

Eur Heart J
Van Linthout S, Matz I, González A, Davis J.   +3 more
europepmc   +1 more source

Amyloid β alters vascular CaV1.2 channel spatiotemporal properties

The Journal of Physiology, EarlyView.
Abstract figure legend Amyloid‐β1‐42 (Aβ1‐42) triggers a male‐specific signalling cascade influencing CaV1.2 spatiotemporal properties in cerebral vascular smooth muscle. The signalling pathway involves NADPH oxidase (NOX)‐derived reactive oxygen species (ROS) activation of protein kinase C (PKC). Aβ1‐42 can also activate protein kinase A (PKA).
Jade L. Taylor, Miguel Martin‐Aragon Baudel, Eric Pereira da Silva, Johannes W. Hell, Madeline Nieves‐Cintron, Manuel F. Navedo   +5 more
wiley   +1 more source

Electrophysiological Mechanisms of ST Segment and T-Wave Changes: Insights into Ischemia, Conduction Delay, Hypertrophy, and Electrolyte Disturbance. [PDF]

Ann Card Anaesth
Neema PK, Panidapu N.
europepmc   +1 more source