Results 161 to 170 of about 81,648 (268)

Effect of VSOR/VRAC blocker tamoxifen on contractile activity of primary neonatal cardiomyocytes and isolated perfused heart. [PDF]

BMC Res Notes
Maksimcheva GV, Oljaev ND, Mansurov MM, Fayziev DD, Tsiferova NA, Merzlyak PG, Kurbannazarova RS, Abdullaev IF, Sabirov RZ.   +8 more
europepmc   +1 more source

Repolarization adaptation to rapid change in heart rate in human models – a review

The Journal of Physiology, EarlyView.
Abstract figure legend This review focuses on non‐invasive assessment of repolarization duration and dispersion (heterogeneity) adaptation to change in heart rate (HR). HR was increased incrementally by left atrial pacing during an electrophysiology (EP) study and by a bolus injection of atropine and in a step up/down fashion by repeated right atrial ...
Lennart Bergfeldt, Karl‐Jonas Axelsson, Pia Dahlberg, Farzad Vahedi, Gunilla Lundahl, Lennart Gransberg   +5 more
wiley   +1 more source

Inhibition of Cyclophilin D Rescues Cardiac Function and Bioenergetic Defects Caused by Neonatal Hypoxia. [PDF]

JACC Basic Transl Sci
Burris JR, Beutner G, Yee M, Simon BV, Swartz MF, Boudreau KB, Cohen ED, Kulkarni CA, Hasan P, Wang H, de Mesy Bentley KL, Hajnóczky G, Alfieris GM, Small EM, Brookes PS, O'Reilly MA, Porter GA.   +16 more
europepmc   +1 more source

Combined inhibition of atrial‐specific potassium currents as a possible anti‐arrhythmic drug therapy: A match made in silico

The Journal of Physiology, EarlyView.
Vladimír Sobota
wiley   +1 more source

Electromechanical modelling and simulation of human‐induced pluripotent stem cell‐derived cardiomyocytes predict drug‐induced contractility effects

The Journal of Physiology, EarlyView.
Abstract figure legend A study described in this paper describes a new tool for hiPSC‐CM electromechanical behaviour simulations using mathematical modelling. The model enables in silico assays making drug testing quick, comprehensive and accurate. New hiPSC‐CM models can be used as a platform to integrate in vitro and in silico findings.
Milda Folkmanaite, Xin Zhou, Andreas Koschinski, Wan‐Hua Hong, Marilù Casini, Manuel Koch, Ursula Ravens, Remi Peyronnet, Manuela Zaccolo, Blanca Rodriguez   +9 more
wiley   +1 more source

Epicardial Contributions to Fibro-Inflammatory Signaling in a Pkp2-Deficient Arrhythmogenic Cardiomyopathy Model. [PDF]

Circ Heart Fail
Han DD, Brooks AC, Baker CD, Dirkx RA, Mickelsen DM, Fisler B, Phadke K, Ashton JM, Delmar M, Small EM.   +9 more
europepmc   +1 more source

Structural determinants of re‐entrant drivers in atrial fibrillation: insights from digital twins derived from 3D micrometre‐resolution imaging of human heart

The Journal of Physiology, EarlyView.
Abstract figure legend Digital heart models of human donor atria with cardiac co‐morbidities revealed that regions with AWT variation, aligned myofibres adjacent to disorganised zones and fibrotic borders promoted the localisation and stability of RDs. AWT had a global influence, whereas fibre orientation and fibrosis exerted chamber‐specific regional ...
Anuradha Kulathilaka, Roshan Sharma, James Kennelly, Ning Li, Jieyun Bai, Bruce H. Smaill, Mark L. Trew, Vadim V. Fedorov, Jichao Zhao   +8 more
wiley   +1 more source

Spatio-temporal targeting of cardiac cells with lipid nanoparticles after myocardial infarction. [PDF]

J Mol Cell Cardiol Plus
Harper RL, Farrugia GE, Krstevski C, Alexander N, Raffaut SR, Harrison T, Thomas A, Kiriazis H, Dogra A, Vidallon MLP, Wang X, Chang H, Donner DG, Lelliott PM, Pinto AR.   +14 more
europepmc   +1 more source

Computational modelling of the pro‐ and antiarrhythmic effects of atrial high rate‐dependent trafficking of small‐conductance calcium‐activated potassium channels

The Journal of Physiology, EarlyView.
Abstract figure legend Small‐conductance calcium‐activated potassium (SK) channels are important for atrial repolarization and can be targeted for atrial‐specific antiarrhythmic treatments. We developed a computational model with a calcium sensor to study the effects of increased pacing rate (5 Hz), which enhances SK‐channel gating and forward ...
Stefan Meier, Dobromir Dobrev, Paul G. A. Volders, Jordi Heijman   +3 more
wiley   +1 more source

Morphological Investigation of Uncharacterised Cardiovascular Structures in Shallow-Diving, Semi-Aquatic Freshwater Turtles (Chelidae: <i>Emydura macquarii</i>). [PDF]

Vet Sci
Gurkin RJ, Spronhle-Barrera C, Noble L, Maisel N, Gordon J, Lam C, Schaffer-White A, Origgi F, Gonzalez-Astudillo V.   +8 more
europepmc   +1 more source