Results 171 to 180 of about 81,793 (268)

Morphological Investigation of Uncharacterised Cardiovascular Structures in Shallow-Diving, Semi-Aquatic Freshwater Turtles (Chelidae: <i>Emydura macquarii</i>). [PDF]

Vet Sci
Gurkin RJ, Spronhle-Barrera C, Noble L, Maisel N, Gordon J, Lam C, Schaffer-White A, Origgi F, Gonzalez-Astudillo V.   +8 more
europepmc   +1 more source

Intercalated disk structure, tissue heterogeneity and ion channel distribution modulate conduction and local calcium influx

The Journal of Physiology, EarlyView.
Abstract figure legend A, three‐dimensional representation of cardiac intercalated disk, reduced to a 100‐partition, computationally efficient network representation. B, ion dynamics within intercalated disk extracellular cleft space. C, rapid pacing leads to localized conduction block in tissue with regions of perturbed intercalated disk (ID ...
Nicolae Moise, Heather L. Struckman, James W. Smyth, Gregory S. Hoeker, Steven Poelzing, Rengasayee Veeraraghavan, Seth H. Weinberg   +6 more
wiley   +1 more source

Epicardial Contributions to Fibro-Inflammatory Signaling in a Pkp2-Deficient Arrhythmogenic Cardiomyopathy Model. [PDF]

Circ Heart Fail
Han DD, Brooks AC, Baker CD, Dirkx RA, Mickelsen DM, Fisler B, Phadke K, Ashton JM, Delmar M, Small EM.   +9 more
europepmc   +1 more source

The multicellular environment of the re‐entrant circuit in post‐myocardial infarction ventricular tachycardia: Beyond fibrosis

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic overview of the temporal evolution of the post‐myocardial infarction substrate leading to ventricular tachycardia. Acute ischaemic injury initiates metabolic and electrophysiological disruption, followed by progressive inflammatory, fibrotic and structural remodelling within the infarct border zone.
Mohammed Obeidat, Jaffar Al‐Sheikhli, Andrew M. Blanks, Joseph Mayer, Nicolas Lellouche, Tarvinder Dhanjal, Christopher O'Shea   +6 more
wiley   +1 more source

Sodium Channel Isoform Diversity Underlies Chamber-Specific Cardiac Excitability. [PDF]

Circ Res
Clark CJ, Anderson CE, Dou A, Dierdorff JM, Galpin JD, Gissot L, Thompson SG, Choi H, Yoon JY, Infield DT, McLendon JM, Hoeger JM, Rabab'h O, Bronk P, Leeds K, Kutschke WJ, Paradee WJ, Boudreau RL, Choi BR, London B, Ahern CA.   +20 more
europepmc   +1 more source

Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights

The Journal of Physiology, EarlyView.
Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò, Miguel Martín‐Aragón Baudel, Charlotte E. R. Smith, Gonzalo Hernandez Hernandez, Donald M. Bers, Patrick M. Boyle, Dobromir Dobrev, Shanna Hamilton, Osama F. Harraz, Na Li, Thomas A. Longden, William E. Louch, Madeline Nieves‐Cintron, Matthew A. Nystoriak, Walter Lee Murfee, Przemysław B. Radwański, Swapnil K. Sonkusare, Manuel F. Navedo, Eleonora Grandi   +18 more
wiley   +1 more source

Active Colitis Attenuates Ventricular Excitation-Contraction Coupling by T-Tubular Remodeling. [PDF]

Biomolecules
Ouille V EJ, Pereira CH, Marinho Y, Kanaporis G, Banach K.   +4 more
europepmc   +1 more source

When NCX switches sides: Experimental and computational insights into Ca2+ regulation in the heart

The Journal of Physiology, EarlyView.
Abstract figure legend Due to its presence inside the dyadic cleft, Na+/Ca2+ exchanger (NCX) builds a functional unit together with L‐type calcium channels and ryanodine receptors in the dyadic cleft. NCX acts bidirectionally (forward and reverse mode) dependent on extracellular calcium ([Ca2+]o) and sodium ([Na+]o) concentrations and the membrane ...
Wilhelm Neubert, Judith Hüttemeister, Paulina Sander, Nagaiah Chamakuri, Felix Hohendanner, Martin Falcke, Frank R. Heinzel   +6 more
wiley   +1 more source

C-Terminus of Ca_v1.3 L-Type Ca²⁺ Channel Upregulates Its Own Gene Expression. [PDF]

Cells
Sleiman Y, Srivastava U, Reisqs JB, Wadgaonkar R, Qu YS, Pouliot V, Chahine M, Boutjdir M.   +7 more
europepmc   +1 more source

An age‐associated decline in the role of the sarcoplasmic reticulum and associated calcium‐handling proteins sets the pace for sinoatrial node function

The Journal of Physiology, EarlyView.
Abstract figure legend Stable, responsive pacemaking in the sinoatrial node is driven by the activity of the funny current (membrane clock), interplay of calcium cycling and release from the sarcoendoplasmic reticulum with depolarising sodium‐calcium exchange current (calcium clock). With increasing age, key proteins associated with calcium cycling are
Sandra A. Jones, Fiona S. Godbeer, Matthew K. Lancaster   +2 more
wiley   +1 more source