Results 131 to 140 of about 81,648 (268)

Sympathetic stimulation can compensate for hypocalcaemia‐induced bradycardia in human and rabbit sinoatrial node cells

The Journal of Physiology, EarlyView.
Abstract figure legend AC: adenylyl cyclase, APT: adenosine triphosphate, AMP: adenosine monophosphate, cAMP: cyclic adenosine monophosphate, PDE: phosphodiesterase, PKA: protein kinase A, PPT: protein phosphatase, P: phosphorylation, RyR: ryanodine receptor, SERCA: sarcoplasmic/endoplasmic reticulum Ca2+‐adenosine triphosphatase, SR: sarcoplasmic ...
Moritz Linder, Tomas Stary, Gergő Bitay, Norbert Nagy, Axel Loewe   +4 more
wiley   +1 more source

Targeting Arrhythmogenic Late Sodium Current by FHF1_A-Derivative FixR in Heart Failure Cardiomyocytes. [PDF]

Circ Res
Hegyi B, Angsutararux P, Chakouri N, Mahling RW, Fossier L, Nguyen HM, Gilhooly S, Almeida VA, Smith CER, Wang L, Ripplinger CM, Martin JL, Ginsburg KS, Bedi KC, Margulies KB, Ben-Johny M, Bers DM.   +16 more
europepmc   +1 more source

Calcium‐activated chloride channels in pericytes and their role in regulating organ blood flow

The Journal of Physiology, EarlyView.
Abstract figure legend Pericytes are microvascular mural cells with diverse roles. Contractile pericytes directly regulate local perfusion, while non‐contractile pericytes coordinate upstream vascular contractility via propagating electrical signals.
Paolo Tammaro, Hikaru Hashitani
wiley   +1 more source

Mathematical model of the zebrafish ventricular cardiomyocyte action potential and calcium transient

The Journal of Physiology, EarlyView.
Abstract figure legend This study presents the development and validation of the first biophysically detailed computational model of the zebrafish ventricular action potential (AP). The model is based on a human cardiomyocyte framework and reparameterized using published and newly generated patch‐clamp recordings of zebrafish ionic currents.
Ludovica Cestariolo, Zachary D. Long, Arie O. Verkerk, Jose M. Ferrero, T. Alexander Quinn, Jose F. Rodriguez Matas   +5 more
wiley   +1 more source

Loss of phospholamban phosphorylation blunts Ca²⁺ handling during the cellular adrenergic response. [PDF]

J Mol Cell Cardiol
Gowda AM, Rogers HT, Ríos Pérez EB, Ponce-Balbuena D, Shenkenberg SL, Ge Y, Alvarado FJ.   +6 more
europepmc   +1 more source

Uncertainty quantification via polynomial chaos expansion of myocardial fibre orientation and cardiac activation patterns

The Journal of Physiology, EarlyView.
Abstract figure legend Graphical representation of methods. We implemented three biventricular geometric models (Zenger et al., 2020) with rule‐based myocardial fibre orientations (Bayer et al., 2018). We evaluated variability in the fibre orientation via four sets of parameter distributions to determine the role of the primary and imbrication angles ...
Lindsay C. R. Tanner, Anna Busatto, Jake A. Bergquist, Wilson W. Good, Brian Zenger, Gernot Plank, Akil Narayan, Karli Gillette, Rob S. MacLeod   +8 more
wiley   +1 more source

Contribution of Cardiac CD34⁺ Stromal Cells to Post-Myocardial Infarction Repair in Middle-Aged Rats. [PDF]

J Histochem Cytochem
Schneider DT, Dedkov EI.
europepmc   +1 more source

Demonstration of beat-to-beat, on-demand ATP synthesis in ventricular myocytes reveals sex-specific mitochondrial and cytosolic dynamics. [PDF]

J Physiol
Abstract figure legend Beat‐locked mitochondrial ATP transients reveal modular, sex‐specific bioenergetic control during excitation–contraction coupling. A, each action potential activates L‐type CaV1.2 channels, producing a Ca2+ influx that triggers ryanodine receptors (RyR2) and elicits SR Ca2+ release.
Rhana P, Matsumoto C, Santana LF.
europepmc   +2 more sources

Mechanisms underlying local Ca2+ signalling differences between right and left atrial myocytes at normal and increased frequencies

The Journal of Physiology, EarlyView.
Abstract figure legend Left atrial myocytes have TAT‐associated faster Ca2+ release but are more prone to maladaptation at higher frequencies due to weaker peripheral SR Ca2+ uptake and smaller trigger Ca2+ current. Abstract Changes in heart rate affect Ca2+ signalling and contractility in ventricular muscle, but the effects on atrial Ca2+ signalling ...
Joon‐Chul Kim, Hieu Trong Huynh, Phuong Kim Luong, Tran Nguyet Trinh, Yixuan Wu, Eleonora Grandi, Sun‐Hee Woo   +6 more
wiley   +1 more source

JNK2 Is a Stress Integrator Driving Atrial Fibrillation Pathogenesis in Aging via Gut-Heart Crosstalk. [PDF]

Circulation
Yan J, Carrillo E, Kohli A, Khanal S, Ricchiuti N, DeSantiago J, Wan X, Han M, Richardson A, Yang M, Rondon J, Shen L, Sun J, Liang Q, Hund TJ, Meller J, Deschenes I, Bare DJ, Ai X.   +18 more
europepmc   +1 more source