Results 201 to 210 of about 141,107 (310)

The β_IV-Spectrin/STAT3 Complex Regulates the Orientation of Cardiac Hypertrophic Growth. [PDF]

Circ Res
Nassal DM, Mohta S, Shaheen R, Liu H, Cavus O, Buck B, Lococo S, Winkle AJ, Pyles JB, Leahy N, Xu X, Hund TJ.   +11 more
europepmc   +1 more source

Repolarization adaptation to rapid change in heart rate in human models – a review

The Journal of Physiology, EarlyView.
Abstract figure legend This review focuses on non‐invasive assessment of repolarization duration and dispersion (heterogeneity) adaptation to change in heart rate (HR). HR was increased incrementally by left atrial pacing during an electrophysiology (EP) study and by a bolus injection of atropine and in a step up/down fashion by repeated right atrial ...
Lennart Bergfeldt, Karl‐Jonas Axelsson, Pia Dahlberg, Farzad Vahedi, Gunilla Lundahl, Lennart Gransberg   +5 more
wiley   +1 more source

Atrial TRPM2 Channel-Mediated Ca²⁺ Influx Regulates ANP Secretion and Protects Against Isoproterenol-Induced Cardiac Hypertrophy and Fibrosis. [PDF]

Cells
Numata T, Tagashira H, Sato-Numata K, Hermosura MC, Abe F, Sakai A, Yamamoto S, Watanabe H.   +7 more
europepmc   +1 more source

Electromechanical modelling and simulation of human‐induced pluripotent stem cell‐derived cardiomyocytes predict drug‐induced contractility effects

The Journal of Physiology, EarlyView.
Abstract figure legend A study described in this paper describes a new tool for hiPSC‐CM electromechanical behaviour simulations using mathematical modelling. The model enables in silico assays making drug testing quick, comprehensive and accurate. New hiPSC‐CM models can be used as a platform to integrate in vitro and in silico findings.
Milda Folkmanaite, Xin Zhou, Andreas Koschinski, Wan‐Hua Hong, Marilù Casini, Manuel Koch, Ursula Ravens, Remi Peyronnet, Manuela Zaccolo, Blanca Rodriguez   +9 more
wiley   +1 more source

Beat-locked ATP microdomains in the sinoatrial node map a Ca2+-timed energetic hierarchy and regional pacemaker roles. [PDF]

J Gen Physiol
Muñoz MF, Matsumoto C, Rhana P, Manning D, Bautista GM, Collier DM, Santana LF.   +6 more
europepmc   +1 more source

Combined inhibition of atrial‐specific potassium currents as a possible anti‐arrhythmic drug therapy: A match made in silico

The Journal of Physiology, EarlyView.
Vladimír Sobota
wiley   +1 more source

Structural determinants of re‐entrant drivers in atrial fibrillation: insights from digital twins derived from 3D micrometre‐resolution imaging of human heart

The Journal of Physiology, EarlyView.
Abstract figure legend Digital heart models of human donor atria with cardiac co‐morbidities revealed that regions with AWT variation, aligned myofibres adjacent to disorganised zones and fibrotic borders promoted the localisation and stability of RDs. AWT had a global influence, whereas fibre orientation and fibrosis exerted chamber‐specific regional ...
Anuradha Kulathilaka, Roshan Sharma, James Kennelly, Ning Li, Jieyun Bai, Bruce H. Smaill, Mark L. Trew, Vadim V. Fedorov, Jichao Zhao   +8 more
wiley   +1 more source

Acute arsenic trioxide inhibits the cardiac transient outward K⁺ current (I_to) and human K_v4.3/KChIP2c channels. [PDF]

Curr Res Struct Biol
Mancilla Simbro C, Islas ÁA, Herrera Salcedo FD, Pérez Cortes E, Ramírez Mata A, Sanchéz González J, Reyes Carmona S, Villa Diaz F, Ríos Cano S, Moreno L, Ruíz Castelan J, López Martínez EL, Scior T, Olea-Amezcua MA, León Magdaleno JS, Villanueva Castillo A, Baez Castillo E.   +16 more
europepmc   +1 more source

Computational modelling of the pro‐ and antiarrhythmic effects of atrial high rate‐dependent trafficking of small‐conductance calcium‐activated potassium channels

The Journal of Physiology, EarlyView.
Abstract figure legend Small‐conductance calcium‐activated potassium (SK) channels are important for atrial repolarization and can be targeted for atrial‐specific antiarrhythmic treatments. We developed a computational model with a calcium sensor to study the effects of increased pacing rate (5 Hz), which enhances SK‐channel gating and forward ...
Stefan Meier, Dobromir Dobrev, Paul G. A. Volders, Jordi Heijman   +3 more
wiley   +1 more source

Protective Effects of Panax ginseng Extract on Endothelin-1- and Isoproterenol-Induced Cardiac Hypertrophy via Maintenance of Mitochondrial Function and Calcium-Reactive Oxygen Species (ROS) Homeostasis. [PDF]

Cureus
Tagashira H, Abe F, Yoshizaki M, Numata T.   +3 more
europepmc   +1 more source