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Commitment and differentiation of cardiac myocytes
Trends in Cardiovascular Medicine, 1992This article reviews what is known about the earliest stages of heart development focusing on the periods of commitment and differentiation of cardiac progenitor cells and their molecular regulation. The pathway from precursor to differentiated cardiac myocyte is crucial to forming a normal, functional heart.
J, Litvin +4 more
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Surface cables of cardiac myocytes
Journal of Molecular and Cellular Cardiology, 1980Abstract Heart muscle cells prepared by mechanical disaggregation were seen by transmission electron microscopy (TEM) to possess an intact glycocalyx. Scanning electron microscopy (SEM) studies of the surface of these cells revealed longitudinally oriented cables, 10 to 12 nm thick.
J, Orenstein, D, Hogan, S, Bloom
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Myocyte Growth and Cardiac Repair
Journal of Molecular and Cellular Cardiology, 2002Introduced several decades ago, the dogma persists that ventricular myocytes are terminally differentiated cells and cardiac repair by myocyte regeneration is completely inhibited shortly after birth. On the basis that cardiac myocytes are unable to divide in the adult heart, myocyte growth under physiologic and pathologic conditions is believed to be ...
Piero, Anversa +3 more
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Microtubules in Cardiac Myocytes
1988Publisher Summary This chapter describes the distribution of microtubules (MTs) in various physiopathological states and of their involvement in a broad spectrum of cellular processes. MTs, like actin filaments, are made up of globular protein subunits that can assemble and disassemble rapidly in the cell.
L, Rappaport, J L, Samuel
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Regulation of glutathione in cardiac myocytes
Journal of Molecular and Cellular Cardiology, 2003Reduced glutathione (GSH) is an essential, multifunctional tripepetide that controls redox-sensitive cellular processes, but its regulation in the heart is poorly understood. The present study used a pharmocological model of GSH depletion to examine cellular mechanisms controlling cardiac GSH. Inhibition of GSH metabolism was elicited in normal rats by
Shumin, Li, Xun, Li, George J, Rozanski
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Gene transfer in cardiac myocytes
Surgical Clinics of North America, 2004Congestive heart failure (CHF) represents an enormous clinical problem and remains a leading cause of death despite advances in treatment. New treatments significantly impact mortality and disease course; they do not cure the underlying pathology. Gene transfer, the ability to genetically reprogram the heart in relevant cardiovascular disease models ...
Babar B, Chaudhri +3 more
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Electrical stimulation of cardiac myocytes
Annals of Biomedical Engineering, 1995The influence of nonuniform cell shape and field orientation on the field stimulation thresholds of cardiac myocytes was studied both experimentally and computationally. The percent change in excitation threshold, which was studied with patch clamp technique, was found to be 182 +/- 83.1% (mean +/- SD) higher when the electric field (EF) was parallel ...
R, Ranjan, N V, Thakor
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How to isolate cardiac myocytes
Cardiovascular Research, 1994A complete technique is described for the isolation of myocytes from mammalian hearts using the Langendorff perfusion technique. The use of calcium-free solution containing collagenase and protease, followed by low calcium solution, consistently results in a large number of calcium tolerant myocytes which are well suited for long periods of ...
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Cardiac Myocyte Terminal Differentiation
Annals of the New York Academy of Sciences, 1995The exact mechanism of terminal differentiation in cardiac myocytes is currently unknown. Studies in the skeletal muscle system provided a model where muscle lineage termination gene directly interacts with Rb to produce and maintain the terminally differentiated state. This interaction provided the critical components for the lock in cell cycle arrest
S K, Tam +3 more
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Confocal Microscopy of Cardiac Myocytes
2013Detailed methods are provided for the preparation and confocal imaging of cardiac myocyte development and differentiation. Examples include protocols for the analysis of cultured myocytes as well as vibratome sections of hearts from embryonic and adult tissue.
Robert L, Price +5 more
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