Results 231 to 240 of about 81,648 (268)

Scaffolding Proteins in Cardiac Myocytes

2008
Post-translational modification, such as protein phosphorylation, plays a critical role to reversibly amplify and modulate signaling pathways. Since kinases and phosphatases have broad substrate recognition motifs, compartmentalization and localization of signaling complexes are required to achieve specific signals.
N L, Chudasama, S O, Marx, S F, Steinberg   +2 more
openaire   +2 more sources

Adrenergic regulation of cardiac myocyte apoptosis

Journal of Cellular Physiology, 2001
AbstractThe direct effects of catecholamines on cardiac myocytes may contribute to both normal physiologic adaptation and pathologic remodeling, and may be associated with cellular hypertrophy, apoptosis, and alterations in contractile function.
K, Singh, L, Xiao, A, Remondino, D B, Sawyer, W S, Colucci   +4 more
openaire   +2 more sources

Calcium Signaling in Cardiac Ventricular Myocytes

Annals of the New York Academy of Sciences, 2005
Abstract: Calcium (Ca) is a multifunctional regulator of diverse cellular functions. In cardiac muscle Ca is a direct central mediator of electrical activation, ion channel gating, and excitation‐contraction (E‐C) coupling that all occur on the millisecond time scale. The key amplification step in E‐C coupling is under tight control of very local [Ca].
Donald M, Bers, Tao, Guo
openaire   +2 more sources

Regulation of cardiac myocyte cell death

Pharmacology & Therapeutics, 2003
Cardiac myocyte death, whether through necrotic or apoptotic mechanisms, is a contributing factor to many cardiac pathologies. Although necrosis and apoptosis are the widely accepted forms of cell death, they may utilize the same cell death machinery. The environment within the cell probably dictates the final outcome, producing a spectrum of response ...
Angela, Clerk, Sharon M, Cole, Timothy E, Cullingford, Joanne G, Harrison, Mika, Jormakka, Donna M, Valks   +5 more
openaire   +2 more sources

Electrophysiology of cardiac myocytes of Aplysia brasiliana

Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, 2002
The electrical properties of Aplysia brasiliana myogenic heart were evaluated. Two distinct types of action potentials (APs) were recorded from intact hearts, an AP with a slow rising phase followed by a slow repolarizing phase and an AP with a 'fast' depolarizing phase followed by a plateau.
Marta M, Souza, Arlete, Stucchi-Zucchi, Antonio C, Cassola, Eliana, Scemes   +3 more
openaire   +2 more sources

Molecular mechanisms of apoptosis in the cardiac myocyte

Current Opinion in Pharmacology, 2001
Cardiac myocytes can undergo programmed cell death in response to a variety of insults and apoptotic elimination of myocytes from the adult myocardium can lead directly to cardiomyopathy and death. Although it remains to be shown that therapy specifically targeting apoptosis will improve the prognosis of ischemic heart disease or heart failure, a ...
N H, Bishopric, P, Andreka, T, Slepak, K A, Webster   +3 more
openaire   +2 more sources

Cardiac myocytes and the cardiac action potential

2010
Cardiac myocytes are the contractile cells of the heart and constitute the bulk of heart mass. There are differences between the myocytes of the ventricles, the atria, and the conduction system: ventricular myocytes are elongated cells and packed with myofibrils (the contractile apparatus) and mitochondria (for ATP production)....
Kenneth T. MacLeod, Steven B. Marston, Philip A. Poole-Wilson, Nicholas J. Severs, Peter H. Sugden   +4 more
openaire   +1 more source

Simplified Models for Electromechanics of Cardiac Myocyte

2020
The study of the electromechanical activity of the heart through computational models is important for the interpretation of several cardiac phenomena. However, computational models for this purpose can be computationally expensive. In this work, we present the simplified models at the cellular level which were able to qualitatively reproduce the ...
João Gabriel Rocha Silva, Ricardo Silva Campos, Carolina Ribeiro Xavier, Rodrigo Weber dos Santos   +3 more
openaire   +1 more source

Leptofibrils in Cardiac Myocytes

Ultrastructural Pathology, 1988
Eloisa Arbustini, Victor Ferrans, H. David, F. N. Ghadially   +3 more
openaire   +2 more sources

Autophagy in cardiac myocytes.

Recent advances in studies on cardiac structure and metabolism, 1978
The fetal mouse heart (FMH) in organ culture continues to beat for a period of weeks, but degenerative changes occur. Electron microscopy revealed formation of autophagic vacuoles containing damaged organelles in some cells after the first day, indicating focal cytoplasmic injury.
H D, Sybers, J, Ingwall, M, DeLuca
openaire   +1 more source