Results 221 to 230 of about 78,026 (273)

Obesity-induced activation of NADPH oxidase 2 prolongs cardiac repolarization via inhibiting K+ currents. [PDF]

PLoS One
Li B, Chen Y, Zhao M, Chen Z, Lin Z, Liu J, Wang X, Zhang J, Li Y.   +8 more
europepmc   +1 more source

Sympathetic stimulation can compensate for hypocalcaemia‐induced bradycardia in human and rabbit sinoatrial node cells

The Journal of Physiology, EarlyView.
Abstract figure legend AC: adenylyl cyclase, APT: adenosine triphosphate, AMP: adenosine monophosphate, cAMP: cyclic adenosine monophosphate, PDE: phosphodiesterase, PKA: protein kinase A, PPT: protein phosphatase, P: phosphorylation, RyR: ryanodine receptor, SERCA: sarcoplasmic/endoplasmic reticulum Ca2+‐adenosine triphosphatase, SR: sarcoplasmic ...
Moritz Linder, Tomas Stary, Gergő Bitay, Norbert Nagy, Axel Loewe   +4 more
wiley   +1 more source

Immune checkpoint inhibitors and myocarditis: Lessons from a nationwide cohort study. [PDF]

Oncoscience
Tiwari B.
europepmc   +1 more source

Hyperglycaemia‐induced reactive oxygen species production in cardiac ventricular myocytes differs among mammals

The Journal of Physiology, EarlyView.
Abstract figure legend In rat and human adult ventricular myocytes, acute hyperglyceaemia (Glucose) causes increased glucose uptake (via GLUT) leading to O‐GlcNAcylation of CaMKII at Ser280, such that CaMKII activates NADPH oxidase 2 (NOX2) to increase cytosolic reactive oxygen species (ROS). That perturbs the ROS to Antioxidant (AntiOx) balance.
Shan Lu, Maria J. Baier, Risto‐Pekka Polonen, Zhandi Liao, Jody L. Martin, Kenneth S. Ginsburg, Julian Mustroph, Donald M. Bers   +7 more
wiley   +1 more source

14-3-3 promotes sarcolemmal expression of cardiac Ca_V1.2 and nucleates isoproterenol-triggered channel superclustering. [PDF]

Proc Natl Acad Sci U S A
Spooner HC, Costa AD, Westhoff M, Hernández-González A, Ibrahimkhail H, Yarov-Yarovoy V, Horne MC, Dickson EJ, Dixon RE.   +8 more
europepmc   +1 more source

Reply: Macrophage Activation in Systemic Sclerosis. [PDF]

JACC Basic Transl Sci
Jones XM, Soussi S, Bottini N, Ibrahim AGE, Marbán E.   +4 more
europepmc   +1 more source

Electrophysiological characterization of pre‐adolescents born with intrauterine growth restriction: insights from clinical and computational data

The Journal of Physiology, EarlyView.
Abstract figure legend Depolarization and repolarization duration analysis was conducted in preadolescent groups with IUGR and controls using a 12‐lead ECG. Principal component analysis was applied over the 12‐lead ECGs to generate spatially transformed leads better suited for robust ECG fiducial points detection.
Freddy L. Bueno‐Palomeque, Ernesto Zacur, Esther Pueyo, Fàtima Crispi, Pablo Laguna, Ana Mincholé   +5 more
wiley   +1 more source

A large population of cell-specific action potential models replicating fluorescence recordings of voltage in rabbit ventricular myocytes. [PDF]

R Soc Open Sci
Simitev RD, Gilchrist RJ, Yang Z, Myles RC, Burton FL, Smith GL.   +5 more
europepmc   +1 more source

Functional control of heteromeric Kv2.1/6.4 channels by the voltage sensor domain of the silent Kv6.4 subunit

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic illustration of the gating transitions of the Kv2.1–Kv6.4 heteromeric potassium channel. The figure depicts three functional states: the closed state (top left), in which the channel is non‐conducting (the S2 segment (green helix) and a phenylalanine residue (Phe, blue circle) in Kv6.4 are indicated); the open state ...
Debanjan Tewari, Christian Sattler, Klaus Benndorf   +2 more
wiley   +1 more source

Thymosin Beta-4 Modulates Cardiac Remodeling by Regulating ROCK1 Expression in Adult Mammals. [PDF]

Int J Mol Sci
Maar K, Thatcher JE, Karpov E, Rendeki S, Gallyas F, Bock-Marquette I.   +5 more
europepmc   +1 more source