Results 141 to 150 of about 73,235 (299)
Beijie Qi,1,* Yuqi Li,2,* Zhen Peng,2 Zhiwen Luo,3 Xingyu Zhang,2 Jiwu Chen,2 Guoqi Li,2 Yaying Sun2 1Department of Orthopedics, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, People’s Republic of China; 2Department ...
Li G +7 more
core
Myofibroblast in the ligamentum flavum hypertrophic activity
, 2017 Majority of the previous studies compared lumbar spinal stenosis (LSS) and lumbar disc herniation (LDH) patients for analyses of LFH. However, the separation of normal/hypertrophied LF has often been ambiguous and the severity of hypertrophic activity ...
Lee, Jang-Bo +23 more
core +1 more source
BMEMat, EarlyView.This review comprehensively summarizes emerging biomaterial‐based strategies and underlying mechanisms for modulating endogenous tendon stem/progenitor cells (TSPCs). It offers the most recent insights into TSPC physiology and potential applications of tissue engineering and regenerative medicine in tendons.
Zeyu Zhu +9 more
wiley +1 more source
, 2015 Cardiac myofibroblast differentiation, as one of the most important cellular responses to heart injury, plays a critical role in cardiac remodeling and failure.
YuHui Li +13 more
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Harnessing blood clot as a native scaffold for orchestrating tissue repairs and regeneration
BMEMat, EarlyView.The blood clot, owing to its dynamic composition and unique microenvironment, holds significant yet underappreciated potential for tissue engineering. This review systematically summarizes the pathophysiology of clot formation, the key regulatory factors shaping its microenvironment, and its applications in both pre‐clinical and clinical settings ...
Gao‐peng Dang +13 more
wiley +1 more source
Inhibition of PI3K-Akt pathway by LY294002 inhibits myofibroblast differentiation.
, 2013 Primary HLFs were treated with the PI3K inhibitor LY294002 (50µM) followed by TGFβ (5ng/ml) for 48 hours and A, immunoblots were performed to detect expression of the indicated proteins, and B, immunofluorescence for αSMA (green) was performed to assess ...
Keith C. Olsen (358001) +5 more
core +1 more source
Integrating chemo‐mechanical cues in nano‐microscale environments for stem cell regulation
BMEMat, EarlyView.Nano/microscale control strategies, including nano/microscale materials, ligand spacings, and cell encapsulating gels, cell mechanics, integrin signaling, and biochemical cues to direct stem cell fate, tissue regeneration, and organoid engineering, enabling advanced biomedical applications through mechanoregulation at cell‐material interfaces ...
Rajendra K. Singh +5 more
wiley +1 more source
BMEMat, EarlyView.The core‐shell microneedle patch VP@FNV‐CuO2‐MN was fabricated by encapsulating n‐CuO2 in a moderately crosslinked PVA/CMCS/Borax4 hydrogel shell and VP‐loaded fibroblast membrane nanovesicles (VP@FNV) in a highly crosslinked PVA/CMCS/Borax6 hydrogel core. Upon application to an infected wound, the acidic microenvironment triggers Fenton‐like reactions
Ziwei Jiang +12 more
wiley +1 more source
The Role of PLCB1 In Myofibroblast Differentiation
Fibroblast-to-myofibroblast differentiation is a necessary process for wound repair, but dysregulation can cause fibrosis. This study examines the role of phospholipase C beta 1 (PLCβ1) in regulating myofibroblast differentiation through ɑ-SMA expression.
Mullins, Annabelle
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Myofibroblast contraction activates latent TGF-beta1 from the extracellular matrix
The conjunctive presence of mechanical stress and active transforming growth factor beta1 (TGF-beta1) is essential to convert fibroblasts into contractile myofibroblasts, which cause tissue contractures in fibrotic diseases. Using cultured myofibroblasts
Hinz, Boris +3 more
core +1 more source