Results 151 to 160 of about 59,231 (244)

The Use of Non‐Selective Beta‐Blockers in Cirrhotic Portal Hypertension

Portal Hypertension &Cirrhosis, EarlyView.
Non‐selective beta‐blockers (NSBBs) reduce portal pressure and play a key role in preventing variceal bleeding, managing ascites, and preventing hepatocellular carcinoma (HCC) in cirrhotic patients. Their clinical application requires individualized strategies and further optimization of indications. ABSTRACT Liver cirrhosis is the end stage of various
Tong Bu, Tianyuan Yang, Qi Wang
wiley   +1 more source

Inflammatory bowel disease and extracellular matrix: when victim becomes double agent. [PDF]

Inflamm Res
Sferra R, Vetuschi A, Latella G, Cappariello A, Pompili S.   +4 more
europepmc   +1 more source

From HBV to MASLD Cirrhosis: Mechanistic Insights and Therapeutic Strategies

Portal Hypertension &Cirrhosis, EarlyView.
This review examines the epidemiological shift from hepatitis B virus (HBV) to metabolic dysfunction‐associated steatotic liver disease (MASLD) as the leading cause of cirrhosis globally. It highlights the distinct pathogenic mechanisms between HBV and MASLD cirrhosis and discusses evolving diagnostic tools and therapeutic strategies tailored to the ...
Hanqi Yu, Hongfan Ding, Yang Huang, Haoze Cao, Yuan Ding, Weilin Wang   +5 more
wiley   +1 more source

Matrix Gla Protein Expression in Pericytes and Myofibroblasts Contributes to Renal Fibrosis. [PDF]

Am J Pathol
Bak K, Kim H, Garland JS, Norman PA, Day AG, Migneault F, Hébert MJ, Holden RM, Murshed M.   +8 more
europepmc   +1 more source

Uric Acid in Metabolic Dysfunction‐Associated Steatotic Liver Disease

Portal Hypertension &Cirrhosis, EarlyView.
MASLD is the most prevalent chronic liver disease worldwide, yet effective pharmacological treatments remain limited. Hyperuricemia is now recognized as a key driver of hepatic steatosis, inflammation, and fibrosis, with elevated serum uric acid levels independently predicting hepatocellular carcinoma and liver‐related mortality.
Rong Wang, Zhenyu Liu, Jun Lin, Weijing Zhang, Xianzhi Liu, Tong Zhang   +5 more
wiley   +1 more source

Multi-omics factor analysis identifies the Tensin 1-Fermitin family homologue 2-Fibronectin 1-Integrin signaling axis as a prognostic determinant in colorectal cancer. [PDF]

Mol Biomed
Chen T, Yang Y, Shi J, Dong F, Xie L, Shan Y, Wang X.   +6 more
europepmc   +1 more source

Establishment and Comparative Analysis of Radiation‐Induced Liver Disease in Normal and Fibrotic Rat Models

Precision Radiation Oncology, EarlyView.
This study successfully established two novel rat models of radiation‐induced liver disease (RILD), one in healthy livers and the other in TAA‐induced fibrotic livers, providing valuable insights into the combined effects of radiation and pre‐existing fibrosis.
Yanting Jiang, Yuxi Ding, Fang Wang, Danni Chen, Weixiang Zhong, Zhongjie Lu, Yixiang J. Wang, Senxiang Yan, Xiaoguang Liu, Feng Zhao   +9 more
wiley   +1 more source

Reversal of Myofibroblast Apoptosis Resistance and Collagen Deposition by Phaseoloidin-Induced Autophagy Attenuates Pulmonary Fibrosis. [PDF]

Biomedicines
Li S, Qian J, Deng L, Liu W, Tang S, Xie W.   +5 more
europepmc   +1 more source

Amentoflavone, a Preferentially TGF‐β Receptor 1 Inhibitor, Alleviates Cardiac Remodeling and Dysfunction Through Modulating the TGF‐β/Smad and MAPK Signaling Pathways

Phytotherapy Research, EarlyView.
Amentoflavone, a preferentially TGF‐ββ receptor 1 inhibitor, attenuates transverse aortic constriction (TAC)‐triggered cardiac hypertrophy, fibrosis, and dysfunction by suppressing downstream Smad and MAPK signaling cascades in cardiomyocytes and cardiac fibroblasts.
Jiangjiao Wu, Chengcheng Zhao, Xiaoping Li, Xinyi Guo, Wenjie Tan, Lu Zhou, Ye Zhang, Jianli Zhang, Shuo Zheng, Chunyu Zeng, Gengze Wu   +10 more
wiley   +1 more source

Orcinol glucoside ameliorates pulmonary fibrosis by suppressing hyaluronic acid synthesis and macrophage M2 polarization via targeting hyaluronic acid synthase 2. [PDF]

Int J Mol Med
Li C, Tang X, Luo X, Lai X, Yang J, Xu Z, Muhetaer G, Xie Y, Huang X, Li H.   +9 more
europepmc   +1 more source