Results 171 to 180 of about 61,389 (261)

Mechanical stiffness orchestrates distinct regulation of MRTFs and YAP/TAZ transcriptional cofactors in hepatocytes

The FEBS Journal, EarlyView.
MRTFs and YAP/TAZ proteins, or mechanosensitive transcriptional cofactors (MRTcoF), regulate common genes associated with cellular contractility and immune cell infiltration. Their differential regulation in response to stiffness is linked to changes in hepatocyte's aspect ratio. MRTFB does not undergo nuclear translocation under these conditions. This
Brenda Selene Torres‐Ortiz, Daniel Pérez‐Calixto, Jorge Carretero‐Ortega, Aida Gabriela Guzman‐López, Diana Cristina Pinto‐Dueñas, Mariana Hernández‐Juárez, Alejandra Jiménez‐Escobar, Adriana Rodríguez‐Hernández, Beatriz Díaz‐Bello, Nathalia Serna‐Márquez, Miguel Ángel Peña‐Rico, Laura Gómez‐Romero, Francisco Gabriel Vázquez‐Cuevas, Genaro Vázquez‐Victorio   +13 more
wiley   +1 more source

Rapidly growing nodule on the knee

JAAD Case Reports
Kirsten M. Johnson, MD, PhD, Ania Henning, MD, Jose A. Plaza, MD, Alisha N. Plotner, MD   +3 more
doaj   +1 more source

Myogenic Differentiation (MyoD) Gene Expression in Cornea and Role in Corneal Myofibroblast Dedifferentiation. [PDF]

Invest Ophthalmol Vis Sci
Tripathi R, Sinha NR, Sood S, Gupta S, Kumar R, Sinha PR, Balne PK, Chaurasia SS, Ghosh A, Mohan RR.   +9 more
europepmc   +1 more source

CD68 and F4/80 Markers Demonstrate Inflammatory Synergism Between Apical Periodontitis and Liver Fibrosis in Wistar Rats

International Endodontic Journal, EarlyView.
ABSTRACT Aim To evaluate CD68 and F4/80 glycoproteins in the worsening of apical periodontitis (AP) and liver fibrosis (LF) in Wistar rats. Methodology Thirty‐two Wistar rats were distributed in the following groups (n = 8): C—control; AP—apical periodontitis; LF—liver fibrosis; APLF—AP and LF.
L. V. Barroti, C. Cantiga‐Silva, M. P. Justo, P. H. C. Oliveira, F. D. Faria, J. Goto, E. Ervolino, G. Sivieri‐Araújo, T. N. Pinheiro, L. T. A. Cintra   +9 more
wiley   +1 more source

Molecular Mechanisms of Cardiac Fibrosis: A Pathologist's Perspective. [PDF]

Curr Issues Mol Biol
Marzullo A, Salzillo C.
europepmc   +1 more source

11‐year‐old girl presenting with blurred vision and progressive right arm weakness

Brain Pathology, EarlyView.
Trung Toan Tran, Thi My Hanh Luong, Bérengère Dadone‐Montaudié, Hong Nhung Ta, Thai Hoc Nguyen, Fanny Burel‐Vandenbos, Gia Du Pham   +6 more
wiley   +1 more source

PDE4 Inhibition in Dermatologic Disease: Impacts Beyond Inflammation

International Journal of Dermatology, EarlyView.
This graphical abstract demonstrates the comprehensive mechanism of PDE4 inhibition in skin physiology. By increasing intracellular cAMP and activating PKA, PDE4 inhibitors exert pleiotropic effects, including immune modulation, pigmentation regulation, barrier enhancement, sensory neuron modulation, and improved wound healing with reduced fibrosis ...
Keana Khodadad, Nicole E. Chin, Raj Chovatiya   +2 more
wiley   +1 more source

Myofibroblasts Induce Neuroplasticity to Promote Pancreatic Inflammation and Cancer Progression. [PDF]

Cancer Discov
Nigri J, Lan W, Fung ML, Kayser C, Deschênes A, Hinds J, Kaushalya S, Pawlak SA, Thalappillil JS, Nadella S, Hilmi M, Park W, Kappagantula R, Park Y, Zhao Z, Preall J, Iacobuzio-Donahue CA, Tracey KJ, Borniger JC, Tuveson DA.   +19 more
europepmc   +1 more source

Measuring success in HS treatment from the physician's and the patient's perspective

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Integrated clinician (HiSCR, IHS4, IHS4‐55, HS‐IGA) and patient (HiSQOL, DLQI) scores, combined with imaging‐based fibrosis and inflammation assessment, redefine treatment success in hidradenitis suppurativa by aligning treat‐to‐target strategies with both inflammatory control and irreversible structural damage.
Georgios Nikolakis, Monika Arenbergerova, Zeljko Mijuskovic, Baoxi Wang, Christos C. Zouboulis   +4 more
wiley   +1 more source

Single-cell landscape of intratumoral heterogeneity and GABA-mediated remodeling of the immune microenvironment in breast cancer metastases. [PDF]

Breast Cancer Res
Tang L.
europepmc   +1 more source