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Myofibroblasts in healing laser excision wounds
Background and Objective: The lack of myofibroblasts, cells responsible for wound contraction, has been suggested to be the underlying factor to the clinically observed minimal contraction in CO 2 laser wounds.
Nammour S, M Luomanen
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Experimental Eye Research, 2016
Myofibroblasts are activated in response to tissue injury with the primary task to repair lost or damaged extracellular matrix. Enhanced collagen secretion and subsequent contraction - scarring - are part of the normal wound healing response and crucial to restore tissue integrity.
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Myofibroblasts are activated in response to tissue injury with the primary task to repair lost or damaged extracellular matrix. Enhanced collagen secretion and subsequent contraction - scarring - are part of the normal wound healing response and crucial to restore tissue integrity.
openaire +2 more sources
Glucagon-like petide-2 acts on colon cancer myofibroblasts to stimulate proliferation, migration and invasion of both myofibroblasts and cancer cells via the IGF pathway [PDF]
Glucagon-like peptide (GLP)-2 stimulates intestinal epithelial proliferation by acting, in part, via IGF release from sub-epithelial myofibroblasts. The response of myofibroblasts to GLP-2 remains incompletely understood.
Andrea Varro, Graham J Dockray
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Advances in Anatomic Pathology, 2004
Malignant tumors composed of myofibroblasts are increasingly being recognized, but their existence remains controversial. Currently accepted examples within this category represent spindle cell or pleomorphic neoplasms of the soft tissues with a spectrum of histological grades.
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Malignant tumors composed of myofibroblasts are increasingly being recognized, but their existence remains controversial. Currently accepted examples within this category represent spindle cell or pleomorphic neoplasms of the soft tissues with a spectrum of histological grades.
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The Myofibroblast in Neoplasia
1999Since its discovery in granulation tissue of healing wounds, now over a quarter of a century ago [22], the myofibroblast has been described in: (1) normal tissue; (2) diverse responses to injury and repair phenomena; (3) quasi-neoplastic proliferative conditions; (4) the stromal response to certain forms of neoplasia; and (5) benign and malignant ...
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50 Years of Myofibroblasts: How the Myofibroblast Concept Evolved
2021Myofibroblasts are key cells in mediating normal wound contraction and promoting connective tissue deformations characteristic of fibrosis and scarring. Five decades ago, myofibroblasts were discovered in electron micrographs of wound granulation tissue as fibroblastic cells containing microfilaments that are organized in bundles like those present in ...
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Inflammatory myofibroblastic tumors
Annals of Surgical Oncology, 2004AbstractIntroductionInflammatory myofibroblastic tumors (IMT) while uncommon may arise within numerous organs. Historically, the literature regarding IMT has been confined to small one organ case series, with few reviews encompassing multiple anatomic sites, and little data regarding adjuvant treatment.MethodsA review of patients with IMT treated at ...
Stephen J, Kovach +6 more
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The Myofibroblast in Dupuytren’s Contracture
Hand Clinics, 1991Dupuytren's contracture nodules, but not cords, contain myofibroblasts. These cells, which combine many electron microscopic, physiologic, and immunohistochemical characteristics of fibroblasts and smooth muscle cells, are probably the active force of contraction.
R, Rudolph, J, Vande Berg
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Myofibroblastic Tumors in Children
Surgical Pathology Clinics, 2010Pediatric myofibroblastic tumors comprise a clinically and pathologically heterogeneous group of neoplasms, including benign tumors, those of intermediate biologic potential, and frankly malignant examples (Box 1). Proper classification is critical for appropriate prognostication, clinical management, and, in some cases, identification of familial ...
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The American Journal of Dermatopathology, 1981
S, Lipper, L B, Kahn, R L, Reddick
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S, Lipper, L B, Kahn, R L, Reddick
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