Results 31 to 40 of about 115,223 (237)

MAM‐Localized MANF Counteracts Microinflammatory Stress to Attenuate Mitochondrial Dysfunction and Cataractogenesis in High Myopia

Advanced Science, EarlyView.
Chronic microinflammation in high myopia suppresses MANF in lens epithelial cells. MANF normally resides within MAMs and promotes ubiquitin‐mediated degradation of the ER Ca2+ pump SERCA2. MANF loss causes pathological SERCA2 accumulation, MAM hyperassembly, and disrupted ER‐to‐mitochondria Ca2+ transfer, leading to mitochondrial failure, oxidative ...
Xin Liu, Hao Li, Ching Kang, Dongling Guo, Shuyu Liu, Jiaqi Meng, Zhiqian Huang, Yu Du, Xiangjia Zhu   +8 more
wiley   +1 more source

Prevalence of refractive error in Europe: the European Eye Epidemiology (E(3)) Consortium. [PDF]

, 2015
To estimate the prevalence of refractive error in adults across Europe. Refractive data (mean spherical equivalent) collected between 1990 and 2013 from fifteen population-based cohort and cross-sectional studies of the European Eye Epidemiology (E(3 ...
Cumberland, P.M., Gabriëlle H. S. Buitendijk, Erke, MG, Astrid Fletcher, Kuijpers, Robert W.A.M., Wolfram, C, Kuijpers, Robert WAM, Cougnard-Grégoire, Audrey, Vingerling, Johannes R., Erke, M.G., Christian Wolfram, Fletcher, Astrid, Kuijpers, R.W., Hammond, Christopher J., Mahroo, Omar, Verhoeven, Virginie, Hogg, Ruth, Wolfram, Christian, Kuijpers, Robert W A M, Luben, RN, Rahi, Jugnoo, Klaver, Caroline C. W., Bertelsen, G., van Duijn, C.M., Anastasopoulos, Eleftherios, Fletcher, A., Rahi, J.S., Robert W. A. M. Kuijpers, Ruth Hogg, Bertelsen, Geir, Hanno, Therese von, Mirshahi, A, Verhoeven, V.J., von Hanno, T, Mahroo, O, Hammond, Christopher J, von Hanno, Therese, Norbert Pfeiffer, Vingerling, J.R., Christopher J. Hammond, Albert Hofman, Klaver, Caroline C W, Cumberland, Phillippa, Hofman, Bert, Hammond, C.J., Verhoeven, Virginie; id_orcid, Meitinger, T, Maja Gran Erke, Fletcher, A, Hogg, Ruth; id_orcid, Cumberland, P, Gieger, Christian, Hammond, CJ, Fotis Topouzis, Creuzot-Garcher, C., Paul J. Foster, Wolfram, C., Khawaja, Anthony P, Buitendijk, Gabriëlle H S, Meitinger, T., Hofman, A., Audrey Cougnard-Grégoire, Buitendijk, G.H., Creuzot Garcher, Catherine, Gieger, C, Buitendijk, Gabriëlle H.S., Delcourt, C, Omar Mahroo, Cornelia M. van Duijn, Bron, A., Woolf, Katie Williams; id_orcid, René Höhn, Bertelsen, G, von Hanno, T., Jean-François Korobelnik, Topouzis, F., Jean-François Dartigues, Mirshahi, A., Dartigues, J.F., Delcourt, C., Korobelnik, Jean-François, Williams, Katie M., Korobelnik, J.F., Gieger, C., Christian Gieger, Vingerling, Johannes R, Williams, KM, van Duijn, Cornelia M., Topouzis, F, Dartigues, JF, Verhoeven, Virginie J.M., Klaver, C.C., Luben, R.N., Khawaja, Anthony P., Geir Bertelsen, Vingerling, Hans, Luben, Robert N, Korobelnik, JF, Höhn, René, Alireza Mirshahi, Bron, A, Pfeiffer, Norbert, van Duijn, Cornelia, Anastasopoulos, E, Hogg, R, Buitendijk, Gabriëlle, Mirshahi, Alireza, Erke, Maja Gran, Virginie J. M. Verhoeven, Cécile Delcourt, Duijn, Cornelia, Klaver, Caroline CW, Creuzot-Garcher, C, Creuzot-Garcher, Catherine, Hofman, Albert, Hohn, R, Foster, PJ, Anthony P. Khawaja, Gran Erke, Maja, Meitinger, Thomas, Khawaja, AP, Khawaja, A.P., Robert N. Luben, Verhoeven, Virginie J M, Anastasopoulos, E., Klaver, Caroline, Foster, Paul J, Cougnard-Grégoire, A., Buitendijk, Gabriëlle HS, Jugnoo Rahi, van Duijn, Cornelia M, Dartigues, Jean-François, Kuijpers, Robert, Cougnard-Gregoire, A, Verhoeven, Virginie JM, Topouzis, Fotis, Klaver, Caroline C.W., Thomas Meitinger, Foster, Paul J., Johannes R. Vingerling, Catherine Creuzot-Garcher, Alain Bron, Caroline C. W. Klaver, Höhn, R., Rahi, J, Katie M. Williams, Luben, Robert N., Pfeiffer, N., Pfeiffer, N, Phillippa Cumberland, Mahroo, O., Williams, Katie M, Bron, Alain, Therese von Hanno, Williams, K.M., Delcourt, Cécile, Foster, P.J., Hammond, Chris, Eleftherios Anastasopoulos, Hogg, R.   +159 more
core   +2 more sources

Establishment of an induced pluripotent stem cell line (FDEENTi001-A) from a patient with pathological myopia

Stem Cell Research, 2019
Pathological myopia (PM) is a retinal degenerative disease with an increasing prevalence in Asia. The peripheral blood mononuclear cells (PBMCs) from a patient with PM were successfully reprogrammed to induced pluripotent stem cells (iPSCs) using ...
Xinyue Bai, Xianjie Yang, Yun Cheng, Ling Chen   +3 more
doaj   +1 more source

Issues of Supplemental Support in Pediatric Ophthalmology

Oftalʹmologiâ, 2020
The ophthalmologist often raises the issues about using of various vitamins, trace elements and other nutrients for the prevention and treatment of the different ocular diseases at their practice.
I. A. Gndoyan
doaj   +1 more source

On classification approaches, terminology and modern principles of treatment of pathologies associated with high myopia. Part 2. Terminology and approaches to classification

Российский офтальмологический журнал, 2023
Axial myopia is a risk factor for the development of many concomitant pathological conditions, including those likely to lead to an irreversible loss of visual functions.
V. V. Neroev, O. V. Zaytseva, E. P. Tarutta, E. V. Bobykin, M. A. Kovalevskaya, R. R. Fayzrakhmanov, P. A. Nechiporenko   +6 more
doaj   +1 more source

Ocular and Systemic Findings in COL2A1 and COL11A1 Stickler Syndrome

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Stickler syndrome is most commonly caused by variants in COL2A1 and COL11A1 genes. The purpose of this study was to describe genetic variants and phenotypes in COL2A1 and COL11A1 Stickler syndrome. We performed a retrospective genotype–phenotype evaluation of COL2A1 and COL11A1 Stickler syndrome subjects. Thirty‐two subjects with COL2A1 and 13
Aileen G. MacLachlan, Jessica A. Kraker, Denise J. Morgan, Lisa A. Schimmenti, M. Elizabeth Hartnett, Eileen S. Hwang   +5 more
wiley   +1 more source

Fuchs\u27 spot in degenerative myopia: Clinico-pathological aspects and laser treatments [PDF]

, 1993
This article reviews representative literature on the epidemiology, clinical observation, pathological examination, and laser treatment of Fuchs\u27 spot in degenerative myopia.
Qian, Oliver
core  

Advanced nanotherapeutics for combating ocular infections: Rational design, antimicrobial mechanisms, and therapeutic breakthroughs

BMEMat, EarlyView.
Nanomaterials revolutionize ocular infection treatment by enabling targeted drug delivery and enhanced antimicrobial efficacy against resistant pathogens. This review systematically explores their rational design, multimodal mechanisms, and translational potential for next‐generation anti‐infective therapies.
Yujia Liu, Xuetian Wen, Yue Tan, Rui Zeng, Yijuan Zhang, Tong Lin, Lan Gong, Zichao Luo   +7 more
wiley   +1 more source

Why acute decreased vision in patients with high myopia is an emergency?

The Pan African Medical Journal, 2014
We report a case of 43 years old women who present myopic CNV (A) causing an acute vision loss. That has not been treated at time causing a chorioretinal atrophy as the angiography (B) and her Optical Coherence Tomography (OCT) (C) shows.
Hajji Chaimae, Rajae Daoudi
doaj   +1 more source

Beyond Skin and Eyes: The Medical and Social Burden of Oculocutaneous Albinism in Africa: A Narrative Review

JEADV Clinical Practice, EarlyView.
ABSTRACT Oculocutaneous albinism (OCA) is a genetic disorder found worldwide, but its impact is particularly pronounced in the African continent. This results from both a higher prevalence and the persistent myths and superstitions surrounding the condition in many African communities.
Rebecca Donadoni, Niccolò Capurro, Alessandro Svizzero, Valeria Brazzelli   +3 more
wiley   +1 more source