Results 1 to 10 of about 32,114 (162)

Prdm1 (Blimp-1) and the expression of fast and slow myosin heavy chain isoforms during avian myogenesis in vitro. [PDF]

PLoS ONE, 2010
Multiple types of fast and slow skeletal muscle fibers form during early embryogenesis in vertebrates. In zebrafish, formation of the earliest slow myofibers in fin muscles requires expression of the zinc-finger transcriptional repressor Prdm1 (also ...
Mary Lou Beermann, Magdalena Ardelt, Mahasweta Girgenrath, Jeffrey Boone Miller   +3 more
doaj   +10 more sources

Human skeletal muscle fiber heterogeneity beyond myosin heavy chains [PDF]

Nature Communications
Skeletal muscle is a heterogenous tissue comprised primarily of myofibers, commonly classified into three fiber types in humans: one “slow” (type 1) and two “fast” (type 2A and type 2X).
Roger Moreno-Justicia, Thibaux Van der Stede, Ben Stocks, Jenni Laitila, Robert A. Seaborne, Alexia Van de Loock, Eline Lievens, Diana Samodova, Leyre Marín-Arraiza, Oksana Dmytriyeva, Robin Browaeys, Kim Van Vossel, Lukas Moesgaard, Nurten Yigit, Jasper Anckaert, Anneleen Weyns, Ruud Van Thienen, Ronni E. Sahl, Edmar Zanoteli, Michael W. Lawlor, Michael Wierer, Pieter Mestdagh, Jo Vandesompele, Julien Ochala, Morten Hostrup, Wim Derave, Atul S. Deshmukh   +26 more
doaj   +2 more sources

Targeting the Sarcomere: Myosin Inhibitors as the Revolutionary Game Changer in Hypertrophic Cardiomyopathy [PDF]

Reviews in Cardiovascular Medicine
Hypertrophic cardiomyopathy (HCM) represents the most common inherited cardiac disease and a leading cause of heart failure, arrhythmias, and sudden cardiac death in young individuals.
Farbod Sedaghat-Hamedani, Elham Kayvanpour, Benjamin Meder   +2 more
doaj   +2 more sources

Loss or Gain: Myosin Heavy Chain Truncations in Hypertrophic Cardiomyopathy [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Soumojit Pal, Jason R. Becker
doaj   +2 more sources

Myofibre Hyper-Contractility in Horses Expressing the Myosin Heavy Chain Myopathy Mutation, MYH1^E321G

Cells, 2021
Myosinopathies are defined as a group of muscle disorders characterized by mutations in genes encoding myosin heavy chains. Their exact molecular and cellular mechanisms remain unclear.
Julien Ochala, Carrie J. Finno, Stephanie J. Valberg   +2 more
doaj   +1 more source

Precise positioning of myosin VI on endocytic vesicles in vivo. [PDF]

PLoS Biology, 2007
Myosin VI has been studied in both a monomeric and a dimeric form in vitro. Because the functional characteristics of the motor are dramatically different for these two forms, it is important to understand whether myosin VI heavy chains are brought ...
David Altman, Debanjan Goswami, Tama Hasson, James A Spudich, Satyajit Mayor   +4 more
doaj   +1 more source

Prediction of Interaction between Fish-derived Antifreeze Peptides and Fish Myosin by Molecular Docking

Shipin gongye ke-ji, 2022
Freeze denaturation during frozen storage is one of the main reasons for the decreased gelation ability of surimi after thawing. The myosin heavy chain (MHC) is the major contributor to the formation of surimi gel.
Wenting JIANG, Xu CHEN, Xixi CAI, Fujia YANG, Dan HUANG, Jianlian HUANG, Shaoyun WANG   +6 more
doaj   +1 more source

A Novel Missense Variant in Actin Binding Domain of MYH7 Is Associated With Left Ventricular Noncompaction

Frontiers in Cardiovascular Medicine, 2022
Cardiomyopathies are a group of common heart disorders that affect numerous people worldwide. Left ventricular non-compaction (LVNC) is a structural disorder of the ventricular wall, categorized as a type of cardiomyopathy that mostly caused by genetic ...
Mahdi Hesaraki, Mahdi Hesaraki, Ugur Bora, Ugur Bora, Sara Pahlavan, Najmeh Salehi, Najmeh Salehi, Seyed Ahmad Mousavi, Maryam Barekat, Seyed Javad Rasouli, Hossein Baharvand, Hossein Baharvand, Gunes Ozhan, Gunes Ozhan, Mehdi Totonchi, Mehdi Totonchi, Mehdi Totonchi   +16 more
doaj   +1 more source

Virus-free transfection, transient expression, and purification of human cardiac myosin in mammalian muscle cells for biochemical and biophysical assays

Scientific Reports, 2023
Myosin expression and purification is important for mechanistic insights into normal function and mutation induced changes. The latter is particularly important for striated muscle myosin II where mutations cause several debilitating diseases.
Lok Priya Velayuthan, Luisa Moretto, Sven Tågerud, Marko Ušaj, Alf Månsson   +4 more
doaj   +1 more source

Expression of non-muscle type myosin heavy polypeptide 9 (MYH9) in mammalian cells

European Journal of Histochemistry, 2009
Myosin is a functional protein associated with cellular movement, cell division, muscle contraction and other functions. Members of the myosin super-family are distinguished from the myosin heavy chains that play crucial roles in cellular processes ...
T Takubo, S Wakui, K Daigo, K Kurokata, T Ohashi, K Katayama, M Hino   +6 more
doaj   +1 more source