Results 271 to 280 of about 32,263 (310)
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Identification of myosin heavy chain in Saccharomyces cerevisiae
Nature, 1985Motility in biological systems is expressed in a variety of ways, such as cytoplasmic streaming, cell shaping, nuclear migration and muscle contraction. These functions are thought to be mediated by structural proteins, for example, myosin, actin and tubulin.
F Z, Watts, D M, Miller, E, Orr
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Slow myosin heavy chain isozyme in nemaline myopathy
Neurology, 1985Muscle biopsies from two sporadic cases of congenital nemaline myopathy were examined for myosin heavy chain composition. Electrophoresis of congenital nemaline myopathy (CNM) muscle myosin in SDS-5% polyacrylamide gels gave rise to a single heavy chain band, with a migration rate and antigenic properties identical to that of the adult slow form, as ...
Biral D +4 more
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Myosin Heavy Chain Isoforms and Smooth Muscle Function
1991Using isoform specific antibodies we have verified the presence of two distinct muscle type myosin heavy chain isoforms in rat uterine muscle. We have shown that an endogenous protease can cleave a small 4 kDa region from the C-terminal of the SM1 isoform which generates a pSM1 species which comigrates with the SM2 isoform on low density SDS gels ...
R J, Paul, T E, Hewett, A F, Martin
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Type II myosin regulatory light chain relieves auto-inhibition of myosin-heavy-chain function
Nature Cell Biology, 2000The F-actin based motor protein myosin II has a key role in cytokinesis. Here we show that the Schizosaccharomyces pombe regulatory light chain (RLC) protein Rlc1p binds to Myo2p in manner that is dependent on the IQ sequence motif (the RLC-binding site), and that Rlc1p is a component of the actomyosin ring.
N I, Naqvi +3 more
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Biochemical and Biophysical Research Communications, 1973
Abstract An antiserum specific to dog myocardial myosin has been developed against highly purified myosin heavy chains. The antiserum is specific for the heavy chains of myosin, giving a single precipitin line in an immunodiffusion assay for either the heavy chains of myosin or native myosin, and does not react with any other myocardial proteins.
J, Wikman-Coffelt +3 more
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Abstract An antiserum specific to dog myocardial myosin has been developed against highly purified myosin heavy chains. The antiserum is specific for the heavy chains of myosin, giving a single precipitin line in an immunodiffusion assay for either the heavy chains of myosin or native myosin, and does not react with any other myocardial proteins.
J, Wikman-Coffelt +3 more
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1998
The basic building block of the contractile apparatus in skeletal and cardiac muscle cell is the sarcomere. This multisubunit structure is composed of a precise geometric arrangement of thick filaments sur-rounded by a hexagonal array of thin filaments, each containing actin and the tro-ponin-tropomyosin regulatory complex.
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The basic building block of the contractile apparatus in skeletal and cardiac muscle cell is the sarcomere. This multisubunit structure is composed of a precise geometric arrangement of thick filaments sur-rounded by a hexagonal array of thin filaments, each containing actin and the tro-ponin-tropomyosin regulatory complex.
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Modulation of Myosin Heavy Chains in Rat Laryngeal Muscle
The Laryngoscope, 1999AbstractObjectives To test the hypothesis that myosin heavy chain (MHC) composition is a biological marker indicative of appropriate and functional reinnervation.Study Design Age‐matched adult rats were randomized for prospective study under three experimental conditions.Methods In adult rats, three e‐perimental conditions were surgically created ...
A, Shiotani, H, Nakagawa, P W, Flint
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Smooth muscle myosin heavy chains combine to form three native myosin isoforms
American Journal of Physiology-Heart and Circulatory Physiology, 1993Two smooth muscle myosin heavy chains (MHC; SM1 and SM2) of approximately 204 and 200 kDa exist in smooth muscle cells and can be visualized on reducing sodium dodecyl sulfate (SDS)-polyacrylamide gels. Chymotryptic digestion of the native myosin molecule results in two fragments: heavy meromyosin (HMM) and light meromyosin (LMM).
Tsao, Allen E., Eddinger, Thomas J.
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Coexpression of myosin heavy chain 2b with myosin heavy chain 1-fact or artefact ?
2001In skeletal muscle, pure fibres expressing one myosin heavy chain (MyHC) isoform, and intermediate fibres, expressing two and exceptionally three MyHCs have been described. When skeltal muscle adapts its fibre profile to changed functional demands MyHC isoform transformation follows the pathway: MyHC-1↔MyHC-2a↔MyHC-2x/d↔MyHC-2b.
Erzen, Ida +4 more
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Molecular genetic dissection of myosin heavy chain function
Cell, 1990Article synthese relatif a la chaine peptidique lourde de la myosine; interet porte a la relation structure ...
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