Results 31 to 40 of about 32,263 (310)

Quantification of Myosin Heavy‐Chain mRNA during Myogenesis [PDF]

European Journal of Biochemistry, 1978
Complementary DNA (cDNA) was synthesized from a 26‐S poly(A)‐containing RNA fraction consisting predominately of myosin mRNA, and used to quantitate the amounts of myosin mRNA during development. RNA · cDNAmyosin hybridizations were performed with RNA isolated from tertiary cultures of chick fibroblasts, and the proportion of myosin RNA determined. The
J, Robbins, S M, Heywood
openaire   +2 more sources

Modification of Loop 1 Affects the Nucleotide Binding Properties of Myo1c, the Adaptation Motor in the Inner Ear [PDF]

, 2010
Myo1c is one of eight members of the mammalian myosin I family of actin-associated molecular motors. In stereocilia of the hair cells in the inner ear, Myo1c presumably serves as the adaptation motor, which regulates the opening and closing of ...
Adamek, Nancy, Coluccio, Lynne M., Geeves, Michael A., Lieto-Trivedi, Alena   +3 more
core   +1 more source

Two essential light chains regulate the MyoA lever arm to promote Toxoplasma gliding motility [PDF]

, 2015
Key to the virulence of apicomplexan parasites is their ability to move through tissue and to invade and egress from host cells. Apicomplexan motility requires the activity of the glideosome, a multicomponent molecular motor composed of a type XIV myosin,
Alonso, Hernan, Egarter, Saskia, Enciso, Marta, Meissner, Markus, Sheiner, Lilach, Smith, Brian J., Striepen, Boris, Tonkin, Christopher J., Williams, Melanie J.   +8 more
core   +2 more sources

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

C57BL/6 life span study: age-related declines in muscle power production and contractile velocity [PDF]

, 2015
Quantification of key outcome measures in animal models of aging is an important step preceding intervention testing. One such measurement, skeletal muscle power generation (force * velocity), is critical for dynamic movement.
Graber, Ted G., Grange, Robert W., Kim, Jong-Hee, McLoon, Linda K., Thompson, LaDora V.   +4 more
core   +2 more sources

Dynein structure and power stroke [PDF]

, 2003
Dynein ATPases are microtubule motors that are critical to diverse processes such as vesicle transport and the beating of sperm tails; however, their mechanism of force generation is unknown.
A Elliot, AF Neuwald, CK Omoto, DJ Asai, DM Woolley, G Mocz, G Mocz, GG Vernon, H Sakakibara, IR Gibbons, IR Gibbons, IR Gibbons, IR Gibbons, IR Gibbons, J Fan, J Frank, K Ogawa, K Shiroguchi, KA Johnson, LM DiBella, M Okuno, M Samsó, MA Gee, MA Gee, ML Walker, MP Koonce, MP Koonce, RB Vallee, RD Vale, RD Vale, RD Vale, S Karki, SA Burgess, SA Burgess, SM King, SM King, T Yagi, UW Goodenough, UW Goodenough, UW Goodenough, UW Goodenough   +40 more
core   +1 more source

MYL6B, a myosin light chain, promotes MDM2-mediated p53 degradation and drives HCC development

Journal of Experimental & Clinical Cancer Research, 2018
Background Identification of novel MDM2 or p53 binding proteins may reveal undefined oncogenes, tumor suppressors, signaling pathways and possible treatment targets.
Xingwang Xie, Xueyan Wang, Weijia Liao, Ran Fei, Nan Wu, Xu Cong, Qian Chen, Lai Wei, Yu Wang, Hongsong Chen   +9 more
doaj   +1 more source

Engineering Skeletal Muscle Grafts with PAX7::GFP-Sorted Human Pluripotent Stem Cell-Derived Myogenic Progenitors on Fibrin Microfiber Bundles for Tissue Regeneration

Bioengineering, 2022
Tissue engineering strategies that combine human pluripotent stem cell-derived myogenic progenitors (hPDMs) with advanced biomaterials provide promising tools for engineering 3D skeletal muscle grafts to model tissue development in vitro and promote ...
Sarah M. Somers, Jordana Gilbert-Honick, In Young Choi, Emily K. W. Lo, HoTae Lim, Shaquielle Dias, Kathryn R. Wagner, Hai-Quan Mao, Patrick Cahan, Gabsang Lee, Warren L. Grayson   +10 more
doaj   +1 more source

Structures of smooth muscle myosin and heavy meromyosin in the folded, shutdown state [PDF]

, 2007
Remodelling of the contractile apparatus within smooth muscle cells is an essential process that allows effective contractile activity over a wide range of cell lengths.
Ankrett, Burgess, Burgess, Burgess, Craig, Craig, Cremo, Cross, Dominguez, Elliott, Elliott, Frank, Fraser, Frederiksen, Gourinath, Houdusse, Hvidt, Ikebe, Joseph M. Chalovich, Knight, Knight, Lauzon, Liu, Matt L. Walker, Mazhari, Offer, Offer, Offer, Olney, Onishi, Onishi, Penczek, Persechini, Peter J. Knight, Quinlan, Rayment, Rhoda J. Hawkins, Rimm, Salzameda, Sellers, Seow, Sheng, Shuizi Yu, Sobieszek, Stafford, Stan A. Burgess, Suzuki, Tama, Thirumurugan, Tonino, Trybus, Trybus, Trybus, Trybus, Wahlstrom, Walker, Wendt, Wendt, Woodhead, Wu, Yanagisawa   +60 more
core   +1 more source

The chicken myosin heavy chain family.

Journal of Biological Chemistry, 1986
We have used a myosin heavy chain gene fragment to probe two chicken genomic libraries. The fragment, derived from a gene expressed in the fast-white fibers of adult chickens, contains 1400 bases upstream from the translational start site and 1600 bases downstream from the initiation codon. Thirty-one unique nonoverlapping clones were isolated.
J, Robbins, T, Horan, J, Gulick, K, Kropp   +3 more
openaire   +2 more sources