Results 51 to 60 of about 32,263 (310)

Geometrically Tunable Scaffold‐Free Muscle Bioconstructs for Treating Volumetric Muscle Loss

Advanced Healthcare Materials, EarlyView.
Volumetric muscle loss is associated with traumatic muscle resulting in permanent functional impairment. Mold‐based, scaffold‐free, high‐density muscle tissue bioconstructs are developed in customizable geometric shapes and sizes. The transplanted rectangular solid‐shaped muscle bioconstructs improved muscle force recovery and tissue regeneration in ...
Bugra Ayan, Gaoxian Chen, Ishita Jain, Sha Chen, Gladys Chiang, Caroline Hu, Renato Reyes, Beu P. Oropeza, Ngan F. Huang   +8 more
wiley   +1 more source

Ablation of smooth muscle myosin heavy chain SM2 increases smooth muscle contractility and results in postnatal death in mice [PDF]

, 2008
The smooth muscle myosin heavy chains (SMHC) are motor proteins powering smooth muscle contraction. Alternate splicing of SHMC gene at the C-terminus produces SM1, and SM2 myosin isoforms; SM2 (200 kDa) contains a unique 9-amino-acid sequence at the ...
Aikawa, Babij, Babu, Cher, Craig, G. J. Babu, Kelley, Lauzon, Loukianov, M. Chi, M. Periasamy, Miano, Morano, Murphy, Nagai, Nagai, Rovner, Rovner, S. Vedamoorthyrao, SOMLYO, Wang, Y. Zhou, Zhou   +22 more
core   +3 more sources

Characterization of a Human Perinatal Myosin Heavy-Chain Transcript [PDF]

European Journal of Biochemistry, 1995
Using a monoclonal antibody specific to the neonatal myosin heavy chain, we have cloned the full‐length heavy chain cDNA from an 18‐week human fetal cDNA library. Ribonuclease protection assays were used to survey a human muscle collection ranging from 11 weeks gestation to 16 years.
E H, Jullian, A M, Kelly, A J, Pompidou, R, Hoffman, S, Schiaffino, H H, Stedman, N A, Rubinstein   +6 more
openaire   +2 more sources

Matrix Stiffness Governs Fibroblasts’ Regulation of Gingival Immune Homeostasis

Advanced Materials, EarlyView.
This study identifies a “mechano‐epigenetic” checkpoint in which matrix stiffness governs the immune responses of gingival fibroblasts. Using biomimetic hydrogels and human gingival explants, the studies revealed that restoring extracellular matrix stiffness actively suppresses inflammation via non‐canonical NF‐κB signaling and DNA methylation ...
Hardik Makkar, Nghi Tran, Yu‐Chang Chen, Kang I. Ko, Rebecca G. Wells, Kyle H. Vining   +5 more
wiley   +1 more source

The membrane periodic skeleton is an actomyosin network that regulates axonal diameter and conduction

eLife, 2020
Neurons have a membrane periodic skeleton (MPS) composed of actin rings interconnected by spectrin. Here, combining chemical and genetic gain- and loss-of-function assays, we show that in rat hippocampal neurons the MPS is an actomyosin network that ...
Ana Rita Costa, Sara C Sousa, Rita Pinto-Costa, José C Mateus, Cátia DF Lopes, Ana Catarina Costa, David Rosa, Diana Machado, Luis Pajuelo, Xuewei Wang, Feng-quan Zhou, António J Pereira, Paula Sampaio, Boris Y Rubinstein, Inês Mendes Pinto, Marko Lampe, Paulo Aguiar, Monica M Sousa   +17 more
doaj   +1 more source

Expression of the myosin light chains 1 and 2 in the developing fast muscle of gilthead sea bream (Sparus aurata) [PDF]

, 2005
Myosin, the major component of striated muscle, is a complex molecule of heavy and light chains, which undergo continuous replacement to meet developmental and environmental demands.
Mamuris, Z., Moutou, Katerina A., Power, Deborah, Silva, Nadia   +3 more
core  

Tropomyosin antibody: the specific localization of tropomyosin in nonmuscle cells [PDF]

, 1975
An antibody against purified chicken skeletal muscle tropomyosin is used in indirect immunofluorescence to visualize the localization of tropomyosin in a variety of nonmuscle cells.
Lazarides, Elias
core   +2 more sources

Myosin heavy-chain composition in striated muscle after tenotomy [PDF]

Biochemical Journal, 1992
The myosin heavy-chain (MHC) isoform pattern was studied by biochemical methods in the slow-twitch (soleus) and fast-twitch (gastrocnemius) muscles of adult rats during atrophy after tenotomy and recovery after tendon regeneration. The tenotomized slow muscle atrophied more than the tenotomized fast muscle.
JAKUBIECPUKA A, CATANI C, CARRARO, UGO
openaire   +3 more sources

Targeting NRP1 in Endothelial Cells Facilitates the Normalization of Scar Vessels and Prevents Fibrotic Scarring

Advanced Science, EarlyView.
Scars exhibit vascular abnormal alterations, including upregulated NRP1 expression in endothelial cells, increased vascular density and branching, compromised vessel wall integrity, and incomplete pericyte coverage. Therapeutic targeting of NRP1 through hydrogel spray delivery offers a promising approach to normalize aberrant vasculature and prevent ...
Yu Wang, Xin Zhou, Min Liu, Meimei Huang, Peirong Chen, Xinying Li, Fangchao Xue, Wenyan Zhao, Di Liu, Lang Li, Yuangang Lu, Wen Zeng   +11 more
wiley   +1 more source

The importance of subclasses of chitin synthase enzymes with myosin-like domains for the fitness of fungi [PDF]

, 2016
Acknowledgements TG and CF are funded by FEDER funds through the Operational Programme Competitiveness Factors – COMPETE and national funds by FCT – Foundation for Science and Technology under the strategic project UID/NEU/04539/2013. C.F. is a recipient
Fernandes, Chantal, Gonçalves, Teresa, Gow, Neil A. R.   +2 more
core   +1 more source