Results 61 to 70 of about 32,263 (310)

Versatile CRISPR‐Cas Tools for Gene Regulation in Zebrafish via an Enhanced Q Binary System

Advanced Science, EarlyView.
This study introduces CRISPR‐Q, a transgenic CRISPR‐Cas system leveraging the QFvpr/QUAS binary expression platform in zebrafish. CRISPR‐Q overcomes previous challenges in achieving stable and efficient gene regulation. By enabling precise spatiotemporal control of transcript knockdown (CRISPR‐QKD) and gene activation (CRISPR‐Qa), it provides a ...
Miaoyuan Shi, Weiqi Ge, Changheng Li, Bin Liu, Xiaoyi Deng, Chengjie Liu, Meijun Zheng, Pu Zhang, Lei Li, Ying Guo, Yunqi Han, Yu Yang, Yanxun V. Yu, Youngnam N. Jin   +13 more
wiley   +1 more source

Iron overload exacerbates age-associated cardiac hypertrophy in a mouse model of hemochromatosis

Scientific Reports, 2017
Cardiac damage associated with iron overload is the most common cause of morbidity and mortality in patients with hereditary hemochromatosis, but the precise mechanisms leading to disease progression are largely unexplored.
Abitha Sukumaran, JuOae Chang, Murui Han, Shrutika Mintri, Ban-An Khaw, Jonghan Kim   +5 more
doaj   +1 more source

Proteome dynamics during contractile and metabolic differentiation of bovine foetal muscle

Animal, 2009
Contractile and metabolic properties of bovine muscles play an important role in meat sensorial quality, particularly tenderness. Earlier studies based on Myosin heavy chain isoforms analyses and measurements of glycolytic and oxidative enzyme activities
T. Chaze, B. Meunier, C. Chambon, C. Jurie, B. Picard   +4 more
doaj   +1 more source

Smooth Muscle Myosin Heavy Chain Isoform Distribution in the Swine Stomach [PDF]

, 2002
To evaluate the distribution of smooth muscle myosin heavy chain isoforms (SMB, with head insert), we examined frozen sections from the various regions of swine stomachs using isoform-specific antibodies.
Eddinger, Thomas J., Parisi, Jonathan A.
core   +1 more source

Protein multi-scale organization through graph partitioning and robustness analysis: Application to the myosin-myosin light chain interaction

, 2011
Despite the recognized importance of the multi-scale spatio-temporal organization of proteins, most computational tools can only access a limited spectrum of time and spatial scales, thereby ignoring the effects on protein behavior of the intricate ...
A Delmotte, Aynaud T, Blondel V D, Delano W L, Delmotte A, E W Tate, Hettmann C, Lambiotte R Delvenne J C Barahona M, M Barahona, Meliga S, Meliga S Yaliraki S N Barahona M, Newman M E J, S N Yaliraki, Schiaffino S   +13 more
core   +1 more source

Skeletal Myogenic Progenitors Originating from Embryonic Dorsal Aorta Coexpress Endothelial and Myogenic Markers and Contribute to Postnatal Muscle Growth and Regeneration [PDF]

, 1999
Skeletal muscle in vertebrates is derived from somites, epithelial structures of the paraxial mesoderm, yet many unrelated reports describe the occasional appearance of myogenic cells from tissues of nonsomite origin, suggesting either ...
Berghella, Libera, Coletta, Marcello, Cossu, Giulio, Cusella-De Angelis, M. Gabriella, De Angelis, Luciana, Lattanzi, Laura, Ponzetto, Carola, Zanchi, Malvina   +7 more
core   +2 more sources

Unraveling the Morphological and Functional Maturation Mechanisms Underlying Human Neural Development Using iPSCs‐Derived Neuronal Model

Advanced Science, EarlyView.
Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...
Yue Tian, Yi‐Chun Ou, Zi‐Xian Zhang, Jie Cai, Si‐Qing Cai, Guo‐Gang Xing   +5 more
wiley   +1 more source

Calcium-independent contraction in lysed cell models of teleost retinal cones: activation by unregulated myosin light chain kinase or high magnesium and loss of cAMP inhibition. [PDF]

, 1987
The retinal cones of teleost fish contract at dawn and elongate at dusk. We have previously reported that we can selectively induce detergent-lysed models of cones to undergo either reactivated contraction or reactivated elongation, with rates and ...
Ackland, N, Burnside, B
core  

Obesity-induced decreases in muscle performance are not reversible by weight loss [PDF]

, 2017
Background/Objectives: Obesity can affect muscle phenotypes, and may thereby constrain movement and energy expenditure. Weight loss is a common and intuitive intervention for obesity, but it is not known whether the effects of obesity on muscle function ...
A Arslan-Ergul, A Schlegel, AG Little, AM Gordon, AP Palstra, C Canto, C Garenc, C Hammer, CA Stuart, CJ Tanner, D Bournele, D Swank, DA Syme, DF Stodden, DG Allen, EE Patton, F Seebacher, F Seebacher, F Seebacher, F Seebacher, F Seebacher, FW Booth, G Montalbano, G Ramadori, GB Drummond, GB McClelland, GJ Lieschke, H-F Jheng, HM O’Neill, J Altringham, J Mendez, J Rodgers, J Tallis, J Tallis, J Tallis, J-PK Hyatt, JD Altringahm, JD Bruton, JM Wakeling, K Anttila, K Esposito, K Funai, K Gundersen, K Li, K McShea, KF Petersen, L Guarente, LM Pérez, M Dickinson, M Iwabu, M Michel, M Nguyen, MD Nitti, MH Vickers, MS DeNies, N Teasdale, NA Maffiuletti, NL Price, PT Pfluger, R Bassel-Duby, R Josephson, R S James, R Watts, RA Bannister, RC Browning, RS James, RS James, S Garcia-Vicencio, S Jiang, S Larsen, S Utaka, T Garland, T Hasumura, T Newman, T Oka, T van der Meulen, TD Clark, UE Larsson, WS Yang, Y Shimada, Y Song   +80 more
core   +1 more source

Contribution of Gli1+ Adventitial Stem Cells to Smooth Muscle Cells in Atherosclerosis and Vascular Injury

Advanced Science, EarlyView.
Gli1+ adventitial stem cells (ASCs) have been thought to generate smooth muscle cells (SMCs) in atherosclerosis. Using a dual‐recombinase lineage tracing to exclude ectopic labeling, Wang et al. found that Gli1+ ASCs do not contribute to SMCs in atherosclerotic plaques.
Haixiao Wang, Xiuzhen Huang, Jialing Mou, Enci Wang, Yan Li, Wenjuan Pu, Yao Xie, Xiaoling Guo, Lixin Wang, Maoping Chu, Bin Zhou, Chao Niu   +11 more
wiley   +1 more source