Results 81 to 90 of about 32,263 (310)
Non-Muscle Myosin II Isoforms Have Different Functions in Matrix Rearrangement by MDA-MB-231 Cells. [PDF]
PLoS ONE, 2015 The role of a stiffening extra-cellular matrix (ECM) in cancer progression is documented but poorly understood. Here we use a conditioning protocol to test the role of nonmuscle myosin II isoforms in cell mediated ECM arrangement using collagen ...
Bridget Hindman +3 more
doaj +1 more source
The effect of activity on the rat skeletal muscle contractile apparatus [PDF]
, 1996 In 35 m/min running rats the myosin heavy chains have a faster turnover rate in all three types of skeletal muscle fibers. In the ease of 95 m/min running rats the myosin heavy chains turned over faster only in fast-glyeolytie and fast-oxidative ...
Alev, K, Kaasik, P, Seene, T
core +3 more sources
Advanced Science, EarlyView.Schematic diagram depicting the proposed signaling mechanisms underlying the effects of FBXL4 in the setting of cardiac hypertrophy. Under hypertrophic stimulation, cardiomyocytes‐specific overexpression FBXL4 maintains sarcomere integrity and cardiac function by enhancing K48‐linked ubiquitinated degradation of PFN1 at the K70 site.
Xingda Li +11 more
wiley +1 more source
A simple and rapid preparation of smooth muscle myosin 2 for the electron microscopic analysis
Applied MicroscopyThere has been an increase in the demand for purified protein as a result of recent developments in the structural biology of myosin 2. Although promising, current practices in myosin purification are usually time-consuming and cumbersome.
Anahita Vispi Bharda, Hyun Suk Jung
doaj +1 more source
Differential regulation of myofibrillar proteins in skeletal muscles of septic mice
Physiological Reports, 2019 Sepsis elicits skeletal muscle atrophy as a result of decreased total protein synthesis and/or increased total protein degradation. It is unknown how and whether sepsis differentially affects the expression of specific myofibrillar proteins in ...
Vanessa Moarbes +6 more
doaj +1 more source
Advanced Science, EarlyView.Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Xinru Zhang +7 more
wiley +1 more source
Modulation of contractility in human cardiac hypertrophy by myosin essential light chain isoforms [PDF]
, 2017 Cardiac hypertrophy is an adaptive response that normalizes wall stress and compensates for increased workload. It is accompanied by distinct qualitative and quantitative changes in the expression of protein isoforms concerning contractility ...
Hefti, Martin A. +3 more
core
Відділення фізики і астрономії Національної академії наук України [PDF]
, 1999 Developmental changes in myofibrillar protein composition were investigated in the myotomal muscle of the African catfish, Heterobranchus longifilis (Clariidae), by several electrophoretic techniques.
Baras, Etienne +4 more
core +2 more sources
A Python based automated tracking routine for myosin II filaments [PDF]
, 2020 The study of motor protein dynamics within cytoskeletal networks is of high interest to physicists and biologists to understand how the dynamics and properties of individual motors lead to cooperative effects and control of overall network behaviour ...
Köster, Darius Vasco +2 more
core +2 more sources
Genetic Diagnosis and Discovery Enabled by Large Language Models
Advanced Science, EarlyView.We demonstrate that large language models (LLMs) can facilitate genetic diagnosis and discovery. LLMs were used to solve four types of genetic problems of sequentially increased complexity. An LLM‐based pipeline could analyze genetic variants in the genomic sequences of human hearing loss or rare genetic disease patients and assist in identifying ...
Tao Tu +25 more
wiley +1 more source